Category: 101597-25-5

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

1.00 g (2.0 mmol) of the naphthol compound (19) and the following propargyl alcohol compound 0.81 g (3.0 mmol) was dissolved in 50 ml of toluene, 0.02 g of camphorsulfonic acid was further added, and the mixture was stirred under heating reflux for 1 hour. After the reaction, the solvent was removed and purification by chromatography on silica gel gave 1.02 g of a white powdery product. The yield was 69%.

With the rapid development of chemical substances, we look forward to future research findings about 101597-25-5.

Reference:
Patent; Tokuyama Corporation; Izumi, Shinobu; Teranishi, Kazuhiro; Daikoku, Yusuke; Sando, Mitsuyoshi; (46 pag.)JP5721544; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.HPLC of Formula: C17H16O3

The more polar product of Example 1, Step 4 (2,10-bistrifluoromethyl-7,7-dimethyl-5-hydroxy-7H-benzo[C]fluorene,2.6 grams), 1,1-bis-(4-methoxyphenyl)-2-propyn-1-ol (2.26 grams), 14 drops of methane sulfonic acid and 250mL of methylene chloride were combined in a reaction flask and stirred overnight under a nitrogen atmosphere. Thereaction mixture was washed carefully with a mixture of 250 mL of a saturated sodium bicarbonate solution and 250 mLof water. The organic layer was separated, dried over sodium sulfate, and concentrated by rotary evaporation to get abrown solid. This brown solid was purified via flash column chromatography on a silica gel column using a mixture ofhexane and ethyl acetate (80/20) as the eluant to yield 1.5 grams of an off white solid. A NMR spectrum showed theproduct to have a structure consistent with 3,3-bis-(4-methoxyphenyl)-7,10-bistrifluoromethyl-13,13-dimethyl-3H,13Hindeno[2.1-f]naphtho[1,2-b]pyran as represented by the following graphic formula

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; TRANSITIONS OPTICAL INCORPORATED; CHOPRA, ENU; (24 pag.)KR101593284; (2016); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts