New learning discoveries about 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. name: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

General procedure: To a refluxing solution of 5-hydroxy-3-methoxy-7H-benzo[c]fluoren-7-one 12-4 (3.00 g, 10.9 mmol) in a mixture of toluene (123 mL) and 2-butanone (45 mL) were added 1,1-bis(4-methoxyphenyl)propyn-1-ol (5.23 g, 19.5 mmol) and catalytic amount of p-TsOH, and the resulting mixture was refluxed for 30 min. The solution was cooled down to room temperature, then 10% aq. sodium hydroxide (21 mL), tetrahydrofuran (120 mL) and10% aq. sodium chloride were added and the mixture was stirred well. The organic layer was separated, washed with water four times, and the solvent removed in vacuo. To the resulting residue was added acetone (100 mL) and the mixture was refluxed for 1 h. After the mixture was cooled down, the solid material precipitated was collected by filtration. After drying in vacuo, 6-methoxy-3,3-bis(4-methoxyphenyl)benzo[3,4]fluoreno[2,1-b]pyran-13(3H)-one 13-7 was obtained as a dark purple solid (2.47 g, 4.70 mmol) in 43% yield. 13-7: Mp 207-209 C. 1H NMR (CDCl3) delta/ppm 3.77 (3H, s), 3.96 (3H, s), 6.27 (1H, d, J = 10.0 Hz), 6.84 (4H, m), 7.20 (2H, m), 7.40 (5H, m), 7.57 (2H, m), 7.80 (1H, d, J = 8.0 Hz), 7.86 (1H, d, J = 10.0 Hz), 8.27 (1H, d, J = 9.2 Hz). LC-MS 527.2033 (M+1) (Calculated exact mass for C35H27O5 (M+1) 527.1853). FT-IR (KBr) nu/cm-1 3014, 2953, 2831, 1695, 1605, 1505, 1466, 1397, 1373, 1277, 1218.

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Reference:
Article; Momoda, Junji; Izumi, Shinobu; Yokoyama, Yasushi; Dyes and Pigments; vol. 119; (2015); p. 95 – 107;,
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Some tips on 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

Statistics shows that 101597-25-5 is playing an increasingly important role. we look forward to future research findings about 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Application of 101597-25-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, molecular weight is 268.31, as common compound, the synthetic route is as follows.

Step 5 4-Methylbenzenesulfonic acid (3mg) was added to a stirring mixture containing the product from Step 4 (0.042g), and 1 ,1-bis(4-methoxyphenyl)prop- 2-yn-1-ol (0.066g) in 1 ,2-dichloroethane (5mL). After stirring for two hours, the mixture was washed with water, followed by extraction of the aqueous fraction with ethyl acetate, and drying the combined organic fractions over sodium sulfate. The volume of the organic mixture was reduced under vacuum and the crude residue was purified by column chromatography. The NMR of the orange solid was consistent with 2,2-bis(4-methoxyphenyl)-2H- benzo[f]thieno[2′,3′:4,5]thieno[3,2-h]chromene (0.063g).

Statistics shows that 101597-25-5 is playing an increasingly important role. we look forward to future research findings about 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; DENG, Jun; STEPP, Brian, R.; SPITLER, Eric; XIAO, Wenjing; TAMASULO, Massimiliano; WALTERS, Robert, W.; (140 pag.)WO2016/144324; (2016); A1;,
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Sources of common compounds: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Related Products of 101597-25-5, Adding some certain compound to certain chemical reactions, such as: 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol,molecular formula is C17H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101597-25-5.

Analogously to a literature procedure32 TMSCl (0.30mL, 2.4mmol) was added to a solution of alkyne 11g27 (0.46g, 1.7mmol), DMAP (11mg, 0.090mmol) and TEA (0.38mL, 2.7mmol) in THF (3mL) at 25C. After stirring for 4h at 25C the mixture was quenched with 85 H2O, extracted with Et2O, dried with Na2SO4 and evaporated to dryness. The crude product was purified by flash chromatography with PE/EtOAc (97:3). Colorless oil (510mg, 88%). IR (Film): =3283, 3000, 2956, 2903, 2836, 1607, 1585, 1507, 1464, 1441, 1415, 1303, 1249, 1195, 1172, 1119, 1079, 1035, 1024, 1006, 936, 916, 883, 842, 806, 782, 756, 636cm-1. 1H NMR (500MHz, CD2Cl2) delta 0.11 (s, 9H), 2.93 (s, 1H), 3.77 (s, 6H), 6.79-6.84 (m, 4H), 7.41-7.46 (m, 4H) ppm. 13C NMR (126MHz, CD2Cl2) delta 1.75, 55.77, 75.35, 76.94, 87.31, 113.71, 127.71, 139.29, 159.44ppm. HRMS (EI): [M]+ calcd. for C20H24O3Si, 340.1495; found 340.1486.

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Toth, Krisztian; Hoefner, Georg; Wanner, Klaus T.; Bioorganic and Medicinal Chemistry; vol. 26; 22; (2018); p. 5944 – 5961;,
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Extracurricular laboratory: Synthetic route of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Synthetic Route of 101597-25-5 ,Some common heterocyclic compound, 101597-25-5, molecular formula is C17H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 7 The product of Step 6 (4.8 g), was dissolved in dichloromethane (150 mL) in a 3-necked 100 mL round bottom flask, followed by addition of p-toluenesulfonic acid monohydrate (0.4 g). 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol (3.8 g) was added to the reaction mixture slowly. The mixture was stirred at room temperature. After one hour, more 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol, (0.4 g) was added to the reaction mixture. After stirring for two hours, the reaction was worked up with the addition of saturated aqueous NaHCO3 (100 mL). The resulting organic layer was collected and dried over anhydrous MgSO4. The organic layer was concentrated under vacuum to provide product (8.7 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Alcohol – Wikipedia,
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A new synthetic route of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Application of 101597-25-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

A stirred solution of 4-(4-methoxyphenyl)naphthalen-2-ol (0.50 g, 2.0 mmol), 1,1-bis(4-methoxyphenyl)prop-2-yn-1-ol (0.563 g, 2.1 mmol), trimethyl orthoformate (0.424 g, 0.4 mL, 4.0 mmol) and pyridinium p-toluenesulfonate (0.03 g, 0.10 mmol) in 1,2-dichloroethane (25 mL) was heated under reflux for 2 h. The solvent was removed in-vacuo and the residue was purified by elution from silica using EtOAc (30% in hexanes) as eluent to afford the title compound as a viscous orange oil/ foam (0.89 g, 89 %); numax 521, 552, 580, 650, 667, 696, 738, 765, 826, 946, 1000, 1014, 1029, 1093, 1112, 1171, 1198, 1242, 1288, 1302, 1439, 1456, 1505, 1584, 1606 cm-1; 1H NMR (CDCl3) deltaH 3.78 (s, 6H, 2 × OMe), 3.89 (s, 3H, OMe), 6.22 (d, J = 10.0 Hz, 1H, 2-H), 6.84 (app. d, J = 8.7 Hz, 4H, Ar-H), 6.99 (app. d, J = 8.5 Hz, 2H, Ar-H), 7.14 (s, 1H, 5-H), 7.24 – 7.28 (m, 1H, Ar-H), 7.33 (d, J = 9.9 Hz, 1H, 1-H), 7.38 – 7.42 (m, 6H, Ar-H), 7.45 – 7.49 (m, 1H, Ar-H), 7.82 (d, J = 8.4 Hz, 1H, 7-H), 8.01 (d, J = 8.4 Hz, 1H, 10-H); 13C NMR (CDCl3) deltaC 55.3, 82.2, 113.2, 113.4, 113.7, 119.1, 119.3, 121.6, 123.5, 126.4, 126.7, 127.8, 127.9, 128.4, 130.3, 131.0, 132.7, 137.3, 141.8, 150.0, 158.9, 159.1. HRMS found [M+H]+ = 501.2050, C34H28O4 requires [M+H]+ = 501.2060.

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Aiken, Stuart; Armitage, Ben; Gabbutt, Christopher D.; Heron, B. Mark; Tetrahedron Letters; vol. 56; 33; (2015); p. 4840 – 4842;,
Alcohol – Wikipedia,
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A new synthetic route of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C17H16O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C17H16O3

Example 1 [0193] 1.20 g (2.0 mmol) of a naphthol compound represented by the following formula (22) and 0.80 g (3.0 mmol) of a propargyl alcohol compound represented by the following formula (23) were dissolved in 70 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added to the resulting solution, and the obtained mixture was stirred under reflux by heating for 1 hour. After a reaction, the solvent was removed, and the obtained product was purified on silica gel by chromatography to obtain 1.35 g of a white powder product. The yield was 80 %. [0194] The elemental analysis values of this product were 78.22% of C, 6.72 % of H, 1.55 % of N and 3.75 % of S which were almost equal to the calculated values of C52H52O6 (C: 78.26 %, H: 6.81 %, N: 1.66 %, O: 9.48 %, S: 3.80 %) [0195] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 18H peaks based on the methyl proton and methylene proton of a tetramethyl-cyclohexane ring at delta of around 1.0 to 3.0 ppm, 20H peaks based on the methyl proton of a methoxy group, the methyl proton of a methylthio group and the ethylene proton of a morpholino group at delta of around 2.3 to 5.0 ppm and 19H peaks based on an aromatic proton and an alkene proton at delta of around 5.6 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0196] It was confirmed from the above results that the isolated product was a compound represented by the following formula (24).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tokuyama Corporation; TAKAHASHI Toshiaki; TAKENAKA Junji; MOMODA Junji; TERANISHI Kazuhiro; SANDO Mitsuyoshi; IZUMI Shinobu; EP2669277; (2013); A1;,
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Simple exploration of 101597-25-5

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Reference of 101597-25-5, Adding some certain compound to certain chemical reactions, such as: 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol,molecular formula is C17H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101597-25-5.

To the vial tube, 5-hydroxy-7,7,13,13-tetramethyl-7H, 13H-benzo [g] indeno [3,2-b] fluorene (8) (50 mg, 0.13 mmol)1,1-bis (4-methoxyphenyl) prop-2-yl-1-ol (9) (35 mg, 0.13 mmol)P-Toluenesulfonic acid monohydrate (1.0 mg, 0.0053 mmol) was added,Sealed with a Teflon (registered trademark) septum cap, purged with nitrogen and toluene (1.3 mL) was added,And the mixture was stirred at 0 C. for 12 hours.Progress of the reaction was confirmed by TLC (hexane / ethyl acetate = 9/1)After confirming the completion of the reaction, the reaction was terminated with an aqueous solution of sodium hydrogencarbonate, and extraction was carried out using ethyl acetate. The extracted organic layer was dried over magnesium sulfate, filtered, and concentrated. The obtained crude product was isolated and purified by silica gel column chromatography (hexane / ethyl acetate = 19/1 to 9/1) to give 64 mg (77%)of3,3-di (4-methoxyphenyl) -10, 10, 16,16-tetramethyl-3H, 10H, 16H-benzo [3,4] indeno [2 ‘, 3’: 6,7] fluoreno [1,2-b] pyran(10) as a dark green solid.

According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOSOH ORGANIC CHEMICAL COMPANY LIMITED; KITO, FUKASHI; HAGIWARA, HIDEKI; SOGA, SHINICHI; (20 pag.)JP2017/36248; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sources of common compounds: 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 101597-25-5, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C17H16O3

Step 7; The product of Step 6 (4.8 g), was dissolved in dichloromethane (150 mL) in a 3-necked 100 mL round bottom flask, followed by addition of p-toluenesulfonic acid monohydrate (0.4 g). 1 ,1-Bis(4-methoxyphenyl)-2-propyn-1-ol (3.8 g) was added to the reaction mixture slowly. The mixture was stirred at room temperature. After one hour, more 1 ,1-bis(4-methoxyphenyl)-2- propyn-1-ol, (0.4 g) was added to the reaction mixture. After stirring for two hours, the reaction was worked up with the addition of saturated aqueous NaHC03 (100 mL). The resulting organic layer was collected and dried over anhydrous MgS04. The organic layer was concentrated under vacuum to provide product (8.7 g). The product was purified by column chromatography using silica gel and as eluent, a mixture of hexanes/EtOAc,( v/v, 4/1 ) to yield 2 g product. The product was foamed under vacuum and scratched with spatula to provide a solid material. The solid was slurried over methanol (30 mL), filtered and washed with methanol (2 x 20 mL) to provide a grayish product (1.4 g). NMR analysis of the product indicated a structure that was consistent with 3,3-bis-(4-methoxyphenyl)-7-chloro-13,13-dimethyl-3H, 13H- indeno[2′,3′:3,4]naphtho[1 ,2-b]pyran represented by the following graphic formula:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; WO2012/82999; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analyzing the synthesis route of 101597-25-5

With the rapid development of chemical substances, we look forward to future research findings about 101597-25-5.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C17H16O3

Example 11.20 g (2.3 mmol) of a naphthol compound represented by the following formula (19) and 0.80 g (3.0 mmol) of a propargyl alcohol compound represented by the following formula (20) were dissolved in 70 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added to the resulting solution, and the obtained mixture was stirred under reflux by heating for 1 hour.After the reaction, the solvent was removed, and the obtained product was purified by chromatography on silica gel to obtain 1.35 g of a white powder product. The yield rate was 76 %.The elemental analysis values of this product were 80.70 % of C, 6.79 % of H and 12.51 % of O which were almost equal to the calculated values of C52H52O6 (C: 80.80 %, H: 6.78%, O: 12.42 %).When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 18H peaks based on the methyl proton of a tetramethylcyclohexane ring and a methylene proton at delta of around 1.0 to 3.0 ppm, a 15H peak based on the methyl proton of a methoxy group at delta of around 2.3 to 4.5 ppm and 19H peaks based on an aromatic proton and the proton of an alkene at delta of around 5.6 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm.It was confirmed from the above results that the isolated product was a compound represented by the following formula (21).

With the rapid development of chemical substances, we look forward to future research findings about 101597-25-5.

Reference:
Patent; Tokuyama Corporation; EP2479171; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some scientific research about 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference of 101597-25-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, molecular formula is C17H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(c) Methyl 9-methoxy-2,2-bis(4-methoxyphenyl)-2H-naphtho [1,2-b]pyran-5-carboxylate. A solution of methyl 4-hydroxy-6-methoxy-2-naphthoate (1.0g, 4.3 mmol) and 1,1-di(4-methoxyphenyl)prop-2-yn-1-ol (1.16g, 4.3 mmol) in toluene (45 cm3) containing acidic alumina (Brockmann 1), (4.0g) was refluxed for 45 minutes. The cooled solution was filtered and the alumina was washed well with EtOAc (200 cm3). The organic filtrate was washed with aqueous sodium hydroxide (2M, 2 x 50 cm3) and water (10.0 cm3). Removal of the dried (Na2SO4) EtOAc gave an oil which was flash chromatographed over silica using 25% EtOAc in hexane as the eluent to afford a pale yellow solid. Recrystallisation from EtOAc/hexane gave methyl 9-methoxy-2,2-bis(4-methoxyphenyl)-2H-naphtho[1,2-b]pyran-5-carboxylate (yield = 0.79g, theoretical yield = 2.08g 38%, m.p. = 162.5 – 164.0 C (uncorrected)).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; JAMES ROBINSON LIMITED; EP975619; (2007); B1;,
Alcohol – Wikipedia,
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