Category: 101-98-4

Mariella, R. P. published the artcileNovel SNl displacement. Reaction of tertiary amines with acetic anhydride, Computed Properties of 101-98-4, the publication is Canadian Journal of Chemistry (1971), 49(20), 3348-51, database is CAplus.

The action of Ac2O on tertiary amines at reflux may cause the displacement of one of the R groups from the amine. The groups which are displaced are benzyl, tert-Bu, benzhydryl, trityl, and cinnamyl; the groups which are not displaced are Me, Et, Bu, Ph, α-naphthyl, iso-Pr, allyl, and propargyl, An SN 1 mechanism with special steric requirements is consistent with the results.

Canadian Journal of Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manoury, Philippe M. published the artcileSynthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives, Application In Synthesis of 101-98-4, the publication is Journal of Medicinal Chemistry (1986), 29(1), 19-25, database is CAplus and MEDLINE.

N²-[(Acylamino)alkyl]-6,7-dimethoxy-2,4-quinazolinediamines I (e.g., R, R¹, R², n = Me, Me, Ph, 2; Me, H, tetrahydro-2-furyl, 3) were synthesized as potential α₁-adrenoceptor antagonists. In rats at 10 mg/kg po, some I (n = 3) showed good antihypertensive activity, whereas I (n = 2) did not.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application In Synthesis of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Altenbach, Robert J. published the artcileDiaryldiamines with Dual Inhibition of the Histamine H3 Receptor and the Norepinephrine Transporter and the Efficacy of 4-(3-(Methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in Pain, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Medicinal Chemistry (2010), 53(21), 7869-7873, database is CAplus and MEDLINE.

A series of compounds were designed as dual inhibitors of the H₃ receptor and the norepinephrine transporter. Methylamino phenylpropyl pyrrolidinyl ethoxy naphthalenol I (rNET K_i = 14 nM; rH₃R K_i = 37 nM) was found to be efficacious in a rat model of osteoarthritic pain.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gros, Philippe published the artcileFirst activation of sodium amide by polymer-supported alkoxides and amino-alkoxides, HPLC of Formula: 101-98-4, the publication is Reactive & Functional Polymers (2000), 43(1,2), 117-122, database is CAplus.

Polystyrene-supported alkoxides and amino-alkoxides are shown to act as efficient and reusable activating agents of sodium amide. This constitutes an unprecedented example of heterogeneous activation in sodium carbanion chem.

Reactive & Functional Polymers published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Witty, David R. published the artcileSAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849, Formula: C10H15NO, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(18), 4865-4871, database is CAplus and MEDLINE.

We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques were utilized to allow rapid exploration of the structure-activity relationship around this template, leading to compound SB-568849 (I) which possessed good receptor affinity and selectivity. This compound proved to be an antagonist with stability in vivo, an acceptable brain-blood ratio and oral bioavailability.

Bioorganic & Medicinal Chemistry Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C13H14BNO2, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rovnyak, George C. published the artcileDihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents, Product Details of C10H15NO, the publication is Journal of Medicinal Chemistry (1992), 35(17), 3254-63, database is CAplus and MEDLINE.

A series of novel dihydropyrimidine calcium channel blockers that contain a basic group attached to either C(5) or N(3) of the heterocyclic ring has been examined Structure-activity studies show that a 1-(phenylmethyl)-4-piperidinyl carbamate moiety at N(3) and sulfur at C(2) are optimal for vasorelaxant activity in vitro and impart potent and long-acting antihypertensive activity in vivo. One of the title compounds was identified as a lead, and the individual enantiomers (R)- and (S)-I were synthesized. Two key steps of the synthesis were the efficient separation of their diastereomeric ureido derivatives and the high-yield transformation of 2-methoxy intermediates into 2-(p-methoxybenzyl)thio intermediates. Chirality was demonstrated to be a significant determinant of biol. activity, with the dihydropyridine receptor recognizing the enamino ester moiety (R)-I but not the carbamate moiety (S)-I. Dihydropyrimidine (R)-I is equipotent to nifedipine and amlodipine in vitro. In the spontaneously hypertensive rat, (R)-I is both more potent and longer acting than nifedipine and compares most favorably with the long-acting dihydropyridine derivative amlodipine. (R)-I has the potential advantage of being a single enantiomer.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Product Details of C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dharmalingam, K. published the artcileFunctionalization of cellulose-based nanocomposite hydrogel films with zinc oxide complex and grapefruit seed extract for potential applications in treating chronic wounds, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Polymer (2020), 122620, database is CAplus.

In this study, the influence of grapefruit seed extract (GFSE) was studied on citric acid and zinc oxide incorporated cellulose-based hydrogel films. The effect of GFSE (0.25-1.0%, volume/volume) on hydrogel films was examined for their physico-chem., mech., thermal, antioxidant and antibacterial properties. The swelling ratio, tensile strength and thermal stability of films decreased with increase in GFSE concentrations On the other hand, elongation (%) and antioxidant activity of films were found to be 34-60% and 25-79%, resp. for increasing amounts of GFSE. FESEM and FETEM clearly showed that two different types of nanoparticles (50-90 nm and 5-10 nm) were present in GFSE incorporated films. The release of polyphenolic compounds and zinc from films was in sustained manner. Furthermore, the fabricated hydrogel films exhibited antibacterial activity against both E. coli and S. aureus. All these results indicate that the prepared nanocomposite hydrogel films could find their potential applications in wound healing.

Polymer published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Silva-Santos, A. Rita published the artcileSeparation of plasmid DNA topoisomers by multimodal chromatography, Category: alcohols-buliding-blocks, the publication is Analytical Biochemistry (2016), 68-70, database is CAplus and MEDLINE.

The ability to analyze the distribution of topoisomers in a plasmid DNA sample is important when evaluating the quality of preparations intended for gene therapy and DNA vaccination or when performing biochem. studies on the action of topoisomerases and gyrases. Here, the authors describe the separation of supercoiled (s.c.) and open circular (oc) topoisomers by multimodal chromatog. A medium modified with the ligand N-benzyl-N-Me ethanolamine and an elution scheme with increasing NaCl concentration were used to accomplish the baseline separation of s.c. and oc plasmid. The utility of the method is demonstrated by quantitating topoisomers in a purified plasmid sample.

Analytical Biochemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H16Br3N, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Ghannam, Sheikha M. published the artcileStability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS, Category: alcohols-buliding-blocks, the publication is Arabian Journal of Chemistry (2019), 12(8), 1983-1993, database is CAplus.

In this stability-indicating, reversed-phase high-performance liquid chromatog. method for nicardipine (NIC), forced degradation has been employed and the formed degradants were separated on a C18 (150 mm × 3.9 mm, 5μm) anal. column using a mobile phase consisted of 70% methanol: acetic acid containing 0.01 M triethylamine with pH 4. The flow rate was 1.0 mL/min and the photodiode array detection wavelength was 353 nm. Forced degradation of the drug was carried out under acidic, basic, photolytic, and oxidative stress conditions. Chromatog. peak purity data indicated no co-eluting peaks with the main peaks. This method resulted in the detection of seven degradation products. Among these, two major degradation products from basic hydrolysis, one from oxidation by H₂O₂ and four from photolytic stress were identified by mass spectral data. A good linear response was achieved over the range of 0.5-40μg/mL with a limit of detection (LOD) of 0.011μg/mL and limit of quantification (LOQ) of 0.036μg/mL. The suggested method was successfully applied for the anal. of NIC in its com. capsules, with mean% recovery value of 100.11 ± 2.26%. The method was extended to the in vitro determination on NIC in spiked human plasma samples with mean% recovery of 99.04 ± 5.67%. The suggested method was utilized to investigate the kinetics of photolytic induced degradation

Arabian Journal of Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Soares, Ruben R. G. published the artcileSample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out, Product Details of C10H15NO, the publication is Lab on a Chip (2021), 21(15), 2932-2944, database is CAplus and MEDLINE.

With its origin estimated around Dec. 2019 in Wuhan, China, the ongoing SARS-CoV-2 pandemic is a major global health challenge. The demand for scalable, rapid and sensitive viral diagnostics is thus particularly pressing at present to help contain the rapid spread of infection and prevent overwhelming the capacity of health systems. While high-income countries have managed to rapidly expand diagnostic capacities, such is not the case in resource-limited settings of low- to medium-income countries. Aiming at developing cost-effective viral load detection systems for point-of-care COVID-19 diagnostics in resource-limited and resource-rich settings alike, we report the development of an integrated modular centrifugal microfluidic platform to perform loop-mediated isothermal amplification (LAMP) of viral RNA directly from heat-inactivated nasopharyngeal swab samples. The disks were pre-packed with dried n-benzyl-n-methylethanolamine modified agarose beads used to selectively remove primer dimers, inactivate the reaction post-amplification and allowing enhanced fluorescence detection via a smartphone camera. Sample-to-answer anal. within 1 h from sample collection and a detection limit of approx. 100 RNA copies in 10μL reaction volume were achieved. The platform was validated with a panel of 162 nasopharyngeal swab samples collected from patients with COVID-19 symptoms, providing a sensitivity of 96.6% (82.2-99.9%, 95% CI) for samples with Ct values below 26 and a specificity of 100% (90-100%, 95% CI), thus being fit-for-purpose to diagnose patients with a high risk of viral transmission. These results show significant promise towards bringing routine point-of-care COVID-19 diagnostics to resource-limited settings.

Lab on a Chip published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C9H5FO2, Product Details of C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts