Category: 101-98-4

Kobayashi, Takashi published the artcileNovel 2-amino-1,4-dihydropyridine calcium antagonists. I. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having nitroxyalkoxycarbonyl groups at 3- and/or 5-position, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical & Pharmaceutical Bulletin (1995), 43(5), 788-96, database is CAplus and MEDLINE.

Novel 2-amino-1,4-dihydropyridine derivatives, e.g. I (R¹ and R² = nitroxyalkyl, alkyl, N-methyl-N-benzylaminoethyl, R³ = 2- or 3-NO₂C₆H₄, 2,3-Cl₂C₆H₃, 2- or 3-CF₃C₆H₄) were synthesized and their pharmaceutical effect was evaluated in spontaneously hypertensive rats. The structure-activity relationships are discussed in terms of potency, onset-rapidity, and duration of antihypertensive activity. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced on either side of an ester chain.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kobayashi, Takashi published the artcileNovel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-position, COA of Formula: C10H15NO, the publication is Chemical & Pharmaceutical Bulletin (1995), 43(5), 797-817, database is CAplus and MEDLINE.

Novel 2-amino-1,4-dihydropyridine derivatives, e.g. I (R¹ and R² = N,N-dialkylaminoalkyl, 1-benzylpiperidin-3-yl, 1-benzhydrylazetidin-3-yl, Me, iso-Pr, R³ = 3-NO₂C₆H₄, 2,3-Cl₂C₆H₃, 3-CF₃C₆H₄, R⁴= NH₂, CH₃) were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- and 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chem. modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. CS-905, I (R¹ = 1-benzhydrylazetidin-3-yl, R² = iso-Pr, R³ = 3-NO₂C₆H₄, R⁴ = NH₂) exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, COA of Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Liqin published the artcileFK506-Binding Protein Ligands: Structure-Based Design, Synthesis, and Neurotrophic/Neuroprotective Properties of Substituted 5,5-Dimethyl-2-(4-thiazolidine)carboxylates, Computed Properties of 101-98-4, the publication is Journal of Medicinal Chemistry (2006), 49(14), 4059-4071, database is CAplus and MEDLINE.

Structure-based design and discovery of novel neuroimmunophilin FK506-binding protein (FKBP) ligands were pursued in the present study. The binding mode of the known FKBP ligand, 3-(3-pyridyl)-1-propyl- (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate, in a complex with FKBP12 was investigated using LUDI simulation and upon which a novel scaffold structure predicted to possess improved binding affinity was designed. A virtual combinatorial library composed of diverse combinations of two substituted groups was constructed using Project Library, followed by an automated screening of the library against the ligand binding site on FKBP52 using DOCK. Forty-three candidate compounds I [R¹ = Me₃C, EtCMe₂, cyclopentyl, cyclohexyl, n-hexyl, n-octyl, Ph, 4-ClC₆H₄, 2,4,6-Me₃C₆H₂, PhCMe₂CH₂; R² = 3-(3-pyridyl)-1-Pr, Ph(CH₂)₃, H₂C:CH(CH₂)₈, etc.] that displayed favorable binding with the receptor were identified and synthesized. The neurotrophic activity of the candidate compounds was evaluated on chick dorsal root ganglion cultures in vitro. As a result, 15 compounds exhibited pos. effects on ganglion neurite outgrowth in the presence of 0.15 ng/mL NGF, among which 7 compounds at testing concentrations of 1 pM and 100 pM showed greater efficacy than 1 at 100 pM. I [R¹ = Me₃C; R² = 3-(3-pyridyl)-1-propyl; (II)] afforded the most potent effect in promoting the processes of neurite outgrowth and which was in a concentration-dependent manner from 1 pM to 100 pM. Half-maximal effect occurred at about 10 pM. Moreover, II at a dosage of 10 mg/kg was found to be significantly neuroprotective in a mouse peripheral sympathetic nerve injury model induced by 8 mg/kg 6-hydroxydopamine. This study further suggests the clin. potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson’s disease.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C9H11BO4, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Parnes, Howard published the artcileSynthesis of [¹⁴C]-labeled dihydropyridine calcium channel-entry blockers: nicardipine-[4-¹⁴C] and RS-93522-[4-¹⁴C], Synthetic Route of 101-98-4, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1988), 25(6), 621-6, database is CAplus.

The Hantzsch synthesis was used to prepare title compounds I [R = CH₂CH₂NMeCH₂Ph, CH₂CH₂C₆H₄[OCH₂CH(OH)CH₂OH]-p] from m-O₂NC₆H₄¹⁴CHO (II), H₂NCMe:CHCO₂Me, and MeCOCH₂CO₂R. II was prepared in high yield from PhBr and ¹⁴CO₂ in 4 steps.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shafiee, A. published the artcileSynthesis and pharmacological activity of benzo[b]thiophene-3-carboxylic acid derivatives, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Pharmaceutical Sciences (1983), 72(2), 198-202, database is CAplus and MEDLINE.

Benzothiophenes I (R = amino, aminoalkyl) and II (R¹ = aminoalkoxy, amino) were prepared from I (R = Cl, N₃) resp. I (R = Me₂NCH₂CH₂) showed significant anticholinergic and antihistamine activity at 1 μg/mL whereas I (R = Me₂NCMe₂CH₂, morpholinoethyl) showed local anesthetic activity comparable to that of lidocaine HCl.

Journal of Pharmaceutical Sciences published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C12H23N3S, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Klein, Jan J. published the artcileSynthesis of a New Class of Bis(thiourea)hydrazide Pseudopeptides as Potential Inhibitors of β-Sheet Aggregation, Formula: C10H15NO, the publication is Organic Letters (2012), 14(1), 330-333, database is CAplus and MEDLINE.

The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display “amphifinity”, i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.

Organic Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Noyola, Martha published the artcileSynthesis and smooth muscle relaxing activity of a series of 1,4-dihydropyridine nicardipine analogs, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Revista de la Sociedad Quimica de Mexico (2003), 47(1), 34-37, database is CAplus.

Nicardipine (I; R = NO₂) and five new analogs I (R = Cl, Br, F, Me, OMe) were synthesized and evaluated for their smooth muscle relaxing activity. All the compounds displayed significant relaxant activity and I (R = Br) was the most potent; the order of potency for the complete set of derivatives were: Br > NO₂ (nicardipine) > Cl ≈ F > Me ≈ OMe.

Revista de la Sociedad Quimica de Mexico published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Na published the artcileDesign, synthesis and preliminary evaluation of novel imperatorin derivatives as vasorelaxant agents, SDS of cas: 101-98-4, the publication is Medicinal Chemistry (2011), 7(1), 18-23, database is CAplus and MEDLINE.

A series of novel imperatorin derivatives (I) were synthesized from com. available xanthotoxin. The in vitro pharmacol. evaluation indicated that all of the compounds possessed potent vasodilatory activity. Among them, compounds (5b) (I, R = allyl), (5d) (I, R = -CH₂CH₂piperidinyl) and (5e) (I, R = -CH₂CH₂azepanyl) exhibited higher vasodilatory activity (with EC₅₀ values of 0.68 μM, 0.59 μM and 0.49 μM, resp.) than imperatorin (EC₅₀ = 1.12 μM). The program Volsurf was used to predict the derivatives’ ADME-relevant descriptors. The results suggested that these novel compounds had a potential interest for the development of novel and potent vasorelaxant agents.

Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shivarkar, Anandkumar B. published the artcileTandem Synthesis of β-Amino Alcohols from Aniline, Dialkyl Carbonate, and Ethylene Glycol, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Industrial & Engineering Chemistry Research (2008), 47(8), 2484-2494, database is CAplus.

An efficient tandem route for selective synthesis of β-amino alcs. from anilines, dialkyl carbonate and ethylene glycol in the presence of recyclable Na-Y zeolite was demonstrated. Transesterification of dialkyl carbonate by ethylene glycol produce ethylene carbonate which further reacts with aniline to give β-amino alcs. in a single step. This reaction system was studied under high-pressure and pot reaction condition. Various process parametric effects were studied for the reaction of aniline, dialkyl carbonate, and ethylene glycol. A maximum 51% yield of mono-β-amino alc., i.e., N-phenylethanolamine (NPEA). Is obtained under pressure conditions. The yield of NPEA was improved drastically (>91%) by carrying out the reaction under pot conditions using di-Et carbonate as transesterification agent. Finally activity and selectivity of solid catalyst was explained on the basis of nature of active sites and pore structure of the catalyst.

Industrial & Engineering Chemistry Research published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H9BFNO3, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sircar, Ila published the artcileCalcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyridinecarboxylate and analogs. Synthesis and structure-activity relationships, Formula: C10H15NO, the publication is Journal of Medicinal Chemistry (1991), 34(7), 2248-60, database is CAplus and MEDLINE.

A series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxylic acid esters and analogs, e.g., I, were prepared via a three component Hantzsch reaction using a substituted benzaldehyde, enamine, and the requisite β-keto ester. These compounds possess unique profile, namely calcium channel blocking and pos. inotropic activities in vitro. Compound I was selected as the best compound in the series and was studied in detail. The synthesis and biol. profiles of enantiomers of I are also reported. The data indicate that although the calcium channel blocking property of I is stereospecific the pos. inotropic activity is not. Examples of 3- and 6-cyano and other closely related 1,4-dihydropyridine derivatives are described and evaluated for comparison and were found to be devoid of dual activities mentioned above.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H6BrF3S, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts