Category: 101-98-4

Shim, Young Key published the artcileNew synthetic route to 1,4-dihydropyridine monoacid derivatives, Quality Control of 101-98-4, the publication is Taehan Hwahakhoe Chi (1988), 32(2), 144-8, database is CAplus.

A novel synthetic route to 1,4-dihydropyridine mono carboxylic acid derivatives is described. Allyl Me 2,6-dimethyl-4-(3′-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate I (R = allyl) was treated with Pd(OAc)₂ in dioxane for 30 min at 100° C with reflux to give the mono acid I (R = H; II) in 94% yield. II was converted to Nicardipine (I, R = CH₂CH₂NMeCH₂Ph) and its derivatives in 70∼85% yield.

Taehan Hwahakhoe Chi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H10CoF6P, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Castro Dantas, T. N. published the artcilePreparation of aminoalkylphosphonium salts, Category: alcohols-buliding-blocks, the publication is Phosphorus and Sulfur and the Related Elements (1982), 13(1), 97-105, database is CAplus.

Three synthetic methods gave aminophosphonium salts Ph₃P⁺(CH₂)_nNRR¹ X^– (n = 2-4; R, R¹ = Me, Et, Me₂CH, Ph, PhCH₂). Yields are better with n = 3, but no intramol. stabilization was detected.

Phosphorus and Sulfur and the Related Elements published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shim, Young Key published the artcileUtilization of 1-[(methanesulfonyl)oxy]-6-(trifluoromethyl)benzotriazole (FMS) as a coupling agent for the esterification of dihydropyridine-3-carboxylic acid, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Bulletin of the Korean Chemical Society (1988), 9(3), 187-8, database is CAplus.

Dihydropyridinedicarboxylates I [R = Et, CHMe₂, (CH₂)₁₀H, CH₂CH₂OMe, CH₂CH₂NMeCH₂Ph, cyclohexyl, CH₂Ph, Ph] were prepared from monoester I (R = H) via benzotriazolyl Me dihydropyridinedicarboxylate II. Thus, I (R = H) was treated with FMS to give II, which was heated with EtOH to give I (R = Et).

Bulletin of the Korean Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C6H17NO3Si, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van Houten, Kelly A. published the artcileA New Strategy for the Design of Monoamine Oxidase Inactivators. Exploratory Studies with Tertiary Allylic and Propargylic Amino Alcohols, SDS of cas: 101-98-4, the publication is Journal of the American Chemical Society (1998), 120(24), 5864-5872, database is CAplus.

A new strategy for the design of monoamine oxidase (MAO) inhibitors is proposed. The strategy is based on the premise that tertiary amine-containing MAO inactivators which operate by alkylation of active site nucleophiles are activated in situ by single electron transfer (SET) to the MAO-flavin cofactor to form aminium cation radicals which undergo secondary fragmentation reactions to produce reactive electrophiles. The purpose of the current work was to assess the feasibility and applicability of this proposal for the design of new families of MAO inactivators. Based on the documented retro-aldol type fragmentation reactivity of β-amino alc. cation radicals, tertiary β-allylic and propargylic β-amino alcs. were expected to serve as precursors of conjugated ketones in SET-promoted processes. Evidence supporting this hypothesis was gained from studies of model SET-photoreactions of members of this amino alc. family with 3-methyllumiflavin. The efficient production of 4a- and 4a,5-flavin adducts in these excited-state reactions demonstrates that aminium radicals, arising by SET-oxidation of tertiary β-allylic and -propargylic β-amino alcs., fragment to generate α,β-unsaturated ketones which react rapidly with the simultaneously formed 3MLF-hydroflavin anion. The second feature of the MAO-inactivator design strategy pathway was tested by examining reactions of the MAOs with substances which contain electrophilic, conjugated enone and ynone moieties tethered to amine functions to ensure delivery to the enzyme active sites. The covalent modification of active site cysteine thiol residues by the unsaturated ketone groups in these substances was confirmed by demonstrating that they serve as active site-directed, time-dependent, nonredox based, inactivators of MAO-A and MAO-B. In the key test of the feasibility of the new MAO-inactivator design strategy, it was shown that selected tertiary β-allylic and -propargylic β-amino alcs. undergo redox reactions in the MAO-A active site which result in inactivation of the enzyme via covalent modification of a single cysteine residue. The exptl. results which support the conclusions stated above are presented and discussed in this paper.

Journal of the American Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H10O2, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boehme, Thomas M. published the artcileStructure-Activity Relationships of Dimethindene Derivatives as New M₂-Selective Muscarinic Receptor Antagonists, Quality Control of 101-98-4, the publication is Journal of Medicinal Chemistry (2003), 46(5), 856-867, database is CAplus and MEDLINE.

2,3-Disubstituted indenes, such as I [R = (Me₂CH)₂N, (FCH₂CH₂)MeN; n = 2], analogs of the widely used histamine H₁ receptor antagonist dimethindene, are prepared as potential M₂-selective muscarinic receptor antagonists. (-)-I [R = (Me₂CH)₂N; n = 2] has comparable affinity for M₂ receptors to (S)-dimethindene with 5-275-fold selectivities for the M₂ muscarinic receptor over other muscarinic receptor subtypes and over histamine H₁ receptors. I [R = (FCH₂CH₂)MeN; n = 2] also has high affinity for the muscarinic M₂ receptor and is selective for the M₂ receptor over other muscarinic receptors but possesses high affinity for histamine H₁ receptors. I (R = Me₂N; n = 1) has the highest affinity of the tested indenes for M₂ muscarinic receptors but low selectivity for M₂ muscarinic receptors over other muscarinic receptor subtypes.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tararov, Vitali I. published the artcileSynthesis of N-(dialkylaminoalkyl)alcohols by homogeneously catalyzed hydrogenolysis of cyclic N,O-acetals, Application of 2-(Benzyl(methyl)amino)ethanol, the publication is Synthesis (2002), 375-380, database is CAplus.

The homogeneously catalyzed hydrogenation of 1,3-oxazolidines affording unsym. substituted 2-N-(dialkylamino)ethanols is reported showing for the 1st time that Rh(I) catalysts based on chelating diphosphines can be advantageous for this reaction.

Synthesis published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C11H13N3, Application of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xin, Zhuo published the artcileRu-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol, SDS of cas: 101-98-4, the publication is ChemSusChem (2020), 13(8), 2007-2011, database is CAplus and MEDLINE.

Highly efficient Ru-catalyzed selective C-C or C-O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines to give β-amino alcs. RR¹N(CH₂)₂OH [R = Ph, 2-MeC₆H4, 4-ClC₆H₄, etc.; R¹ = Me, Et, Bn, etc.] and β-amino ketones ArNR₂CH₂C(O)Me [Ar = Ph, 2-MeC₆H₄, 4-BrC₆H₄, etc.; R² = Me, Bn, etc.] in moderate-to-excellent yields was achieved through the hydrogen-borrowing approach. The use of new redox-active catalysts containing bisphosphine/thienylmethylamine ligands allowed this hydrogen-borrowing system to be operated selectively under both basic and acidic conditions.

ChemSusChem published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H4N2O2, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Traeff, A. M. published the artcileC-F bond substitution via aziridinium ion intermediates, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(68), 13260-13263, database is CAplus and MEDLINE.

Aliphatic 1,2-aminofluorides undergo extremely fast substitution reactions under the influence of lanthanum tris(hexamethyldisilazide). The substitution proceeds via an in situ generated aziridinium ion intermediate, which subsequently undergoes ring opening by addition of a nucleophile, yielding various β-substituted amines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C13H19N5OS, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shibanuma, Tadao published the artcileSynthesis of optically active 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nicardipine), HPLC of Formula: 101-98-4, the publication is Chemical & Pharmaceutical Bulletin (1980), 28(9), 2809-12, database is CAplus and MEDLINE.

(+)- And (-)-nicardipine (I) were prepared from (-)- and (+)-1-ethoxymethyl-5-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (II). Resolution of II was carried out using cinchonidine and cinchonine. The vertebral vasodilating activity of (+)-I.HCl was about 3 times that of (-)-I.HCl.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H6BrFO2, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shimizu, Kuniaki published the artcileReductive cleavage reaction of N,N’-, N,O- and N,S-linked alkylidene compounds by sodium borohydride, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical & Pharmaceutical Bulletin (1974), 22(6), 1256-60, database is CAplus.

NaBH4 reduction was undertaken with a variety of N,n’-, N,O-, and N,S-linked alkylidene compounds (e.g. I-III) in aqueous ethanolic medium at room temperature Reductive cleavage of one of these two alkylidene carbon-heteroatom bonds is generally effected in this reduction The alkylidene bond initially cleaved when the two bonds were different was also determined

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C14H12O2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts