Category: 101-98-4

Azzena, Ugo published the artcileReductive cleavage of N-substituted 2-aryl-1,3-oxazolidines: generation of α-amino-substituted carbanions, SDS of cas: 101-98-4, the publication is Journal of Organic Chemistry (1993), 58(24), 6707-11, database is CAplus.

The behavior of N-substituted 2-aryl-1,3-oxazolidines I (R = H, Me, Ph, R¹ = aryl, R² = Me, Et) have been investigated under conditions of electron transfer from alkali metals in aprotic solvents. The reduction led to the regioselective cleavage of the benzylic carbon-oxygen bond, with formation of the corresponding N-substituted benzylamino alcs. RR¹CHNR²CH₂CH₂OH in good yields. Investigation of the mechanism of this reductive cleavage, with the aid of labeling experiments, showed the intermediate formation of α-tertiary amino-substituted carbanions.

Journal of Organic Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Doyle, F. P. published the artcileChemistry and pharmacology of some esters derived from basic alcohols, Application In Synthesis of 101-98-4, the publication is Journal of Medicinal Chemistry (1965), 8(5), 571-6, database is CAplus.

The preparation of a number of α-alkoxy-α,α-diphenylacetates derived from open-chain basic alcs. is described. Some of these compounds possess antitussive activity comparable to that of codeine phosphate and of the same order as that of their analogs which contain pyrrolidine or piperidine rings. 2-Diethylamino-1-(α-methoxy-α,α-diphenylacetoxy)propane rearranged on heating to 1-diethylamino-2-(α-methoxy-α,α-diphenylacetoxy)propane.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application In Synthesis of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leyden, Donald E. published the artcileEquilibrium isotope effects of tertiary amines by NMR and potentiometry, Formula: C10H15NO, the publication is Analytica Chimica Acta (1970), 49(1), 77-81, database is CAplus.

A comparative study of solvent isotope effects on the dissociation eonst. of amine salts, by means of potentiometric and NMR techniques was made. Agreement of the results of the 2 techniques was generally good. The magnetic resonance technique offers an advantage in cases in which the amine is insoluble in neutral or basic solutions An observed correlation between the isotopic shift of N-methyl proton chem. shift and the spin coupling between the Me protons and the N-H proton is mentioned.

Analytica Chimica Acta published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mathis-Noel, Raymonde published the artcileSpectroscopic studies of hydrogen bonding in aliphatic and aromatic amino alcohols, Application of 2-(Benzyl(methyl)amino)ethanol, the publication is Bulletin de la Societe Chimique de France (1970), 3047-56, database is CAplus.

Inter- and intramol. H bonds were studied for a series of amino alcs., which included some aromatic substituted compounds The ir frequencies of the OH and NH bonds were observed for the pure compound and for several dilutions in CCl4. Further, the NMR shifts of these bonds were observed All compounds studied, with the one exception of 1-phenyl-2-N-methyl-N-ethylaminoethanol, showed various intermol. H-bonds in the pure phase, i.e., OH..A, NH…O, NH…N. Compounds with electron donor substituents on N showed intramol. H bonds (C. F. Douberet and Pariand, 1962). Such bonds are also observed for primary amines; they increase as the number of electron donors on the adjacent C increases. Substitution of an electron source or sink for a H on the C bearing the OH will always favor intramol. association Chelation will be suppressed by substitution of a H atom on N; this increases the H-bonding to the π-electrons of an aromatic system, observed at about 3541 cm-1.

Bulletin de la Societe Chimique de France published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afonso, Carlos A. M. published the artcileSynthesis of 2,4,6-tri-substituted-1,3,5-triazines, Synthetic Route of 101-98-4, the publication is Molecules (2006), 11(1), 81-102, database is CAplus and MEDLINE.

Several specific synthetic protocols were developed for the preparation of a range of sym. and non-sym. di- and tri-substituted 1,3,5-triazines containing alkyl, aromatic, hindered, chiral and achiral hydroxyalkyl, ester and imidazole groups , e.g., I (R = H or Me) via sequential nucleophilic substitution of the C-Cl bond by C-O, C-N and C-S bonds, starting from cyanuric chloride.

Molecules published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eriksson, Kjell published the artcileMAb contaminant removal with a multimodal anion exchanger: a platform step to follow protein A, Computed Properties of 101-98-4, the publication is BioProcess International (2009), 7(2), 52-57, database is CAplus.

Monoclonal antibodies (MAbs) constitute approx. 30% of the biopharmaceutical products currently under development. Today, nearly all approved MAb processes include a capture step using protein A. GE Healthcare’s Capto adhere multimodal anion-exchange resin, which has high selectivity for contaminants that remain after protein A separation, represents an addnl. step toward developing highly effective MAb downstream processes. The high purity that follows capture on protein A resins, combined with the multimodal functionality of Capto adhere resin, provides for highly productive, two-step processes.

BioProcess International published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morgan, William Raymond published the artcileNitrogen inversion of tertiary amines in aqueous acid, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of the American Chemical Society (1970), 92(15), 4527-31, database is CAplus.

The kinetics of the N inversion of 3 tertiary amines was studied in aqueous acid by high-resolution NMR. Line-shape anal. of the AB NMR pattern of methylene protons on each compound provided a measure of the rate of interchange of the magnetic environments of these protons, which results upon the reprotonation of the free base following an odd number of inversions. The inversion rate followed a modification of the first-order protolysis reaction given by Grunwald. Inversion rate constants of 108-109 sec-1 are estimated These are compared to inversion rate constants for N atoms in ring systems. A second-order dependence of inversion on the concentration of amine was also found. The rate law for this inversion process follows very closely the second-order proton exchange reaction for the amine in question. Application of solvent isotope effects to the protolysis rate parameters predicted the observed results of N inversion in D2O.

Journal of the American Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shim, Young Key published the artcileNew synthetic route to 1,4-dihydropyridine monoacid derivatives, Quality Control of 101-98-4, the publication is Taehan Hwahakhoe Chi (1988), 32(2), 144-8, database is CAplus.

A novel synthetic route to 1,4-dihydropyridine mono carboxylic acid derivatives is described. Allyl Me 2,6-dimethyl-4-(3′-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate I (R = allyl) was treated with Pd(OAc)₂ in dioxane for 30 min at 100° C with reflux to give the mono acid I (R = H; II) in 94% yield. II was converted to Nicardipine (I, R = CH₂CH₂NMeCH₂Ph) and its derivatives in 70∼85% yield.

Taehan Hwahakhoe Chi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H10CoF6P, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Castro Dantas, T. N. published the artcilePreparation of aminoalkylphosphonium salts, Category: alcohols-buliding-blocks, the publication is Phosphorus and Sulfur and the Related Elements (1982), 13(1), 97-105, database is CAplus.

Three synthetic methods gave aminophosphonium salts Ph₃P⁺(CH₂)_nNRR¹ X^– (n = 2-4; R, R¹ = Me, Et, Me₂CH, Ph, PhCH₂). Yields are better with n = 3, but no intramol. stabilization was detected.

Phosphorus and Sulfur and the Related Elements published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morgan, William Raymond published the artcileNitrogen inversion of tertiary amines in aqueous acid, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of the American Chemical Society (1970), 92(15), 4527-31, database is CAplus.

The kinetics of the N inversion of 3 tertiary amines was studied in aqueous acid by high-resolution NMR. Line-shape anal. of the AB NMR pattern of methylene protons on each compound provided a measure of the rate of interchange of the magnetic environments of these protons, which results upon the reprotonation of the free base following an odd number of inversions. The inversion rate followed a modification of the first-order protolysis reaction given by Grunwald. Inversion rate constants of 108-109 sec-1 are estimated These are compared to inversion rate constants for N atoms in ring systems. A second-order dependence of inversion on the concentration of amine was also found. The rate law for this inversion process follows very closely the second-order proton exchange reaction for the amine in question. Application of solvent isotope effects to the protolysis rate parameters predicted the observed results of N inversion in D2O.

Journal of the American Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts