Category: 101-98-4

Hasegawa, Tadashi published the artcilePhotocyclization of (ω-dialkylamino)alkyl β-oxoesters via remote hydrogen transfer, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1990), 901-5, database is CAplus.

The (ω-dialkylamino)alkyl β-oxoesters PhCOCR₂CO₂(CH₂)_nN(CH₂R¹)CH₂R² I (n = 2, 3, 4; R = H, Me; R², R³ = H, Ph) undergo photocyclization via remote hydrogen transfer to give the medium-sized azalactones (II) and/or aminolactones III. Intramol. electron transfer from nitrogen to the excited carbonyl group of I occurs prior to the remote hydrogen transfer.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kinugawa, Masahiko published the artcileFacile synthesis of 1,4-dihydropyridine monocarboxylic acids and unsymmetrical dicarboxylates via quaternary ammonium salts of 2-aminoethyl 1,4-dihydropyridine-3,5-dicarboxylates, COA of Formula: C10H15NO, the publication is Synthetic Communications (1997), 27(19), 3321-3331, database is CAplus.

Useful 1,4-dihydropyridine unsym. dicarboxylates nitrendipine (I, R = Et), nicardipine (I, R = CH₂CH₂NMeCH₂Ph) and monocarboxylic acid I (R = H) were prepared from I (R = CH₂CH₂NMeCH₂Ph, N-benzyl-3-piperidinyl) via their quaternary ammonium salts, e.g., II.

Synthetic Communications published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, COA of Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Adger, B. M. published the artcileCatalytic transfer hydrogenolysis of N-benzyl protecting groups, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Synthesis (1987), 53-5, database is CAplus.

The catalytic transfer hydrogenolysis of a number of N-benzyl compounds has been examined Of the three hydrogen donors studied, ammonium formate and hydrazine hydrate were more effective than sodium hypophosphite. In general, debenzylation of secondary and tertiary benzylamines could be readily accomplished by refluxing the substrate with an excess of the hydrogen donor in alc. solvents for a few hours using catalytic amounts of 10% palladium on carbon. The two N-benzyl heteroaromatic amines studied were stable to the above conditions.

Synthesis published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ren, Shen published the artcileDesign, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylic acid derivatives as neuroimmunophilin ligands, Quality Control of 101-98-4, the publication is Zhongguo Yaowu Huaxue Zazhi (2007), 17(1), 1-7, 12, database is CAplus.

A method for the synthesis of the title compounds is reported here. Both, the sequence and conformation of the FK506-binding site in FKBPs (FK506 binding proteins) family are highly conserved. According to this characteristic of FKBPs and the structural feature of ligands binding to FKBP12, CADD (computer-aided drug design) was employed to design and virtually screen novel 2,2-dimethyl-1,3-dioxolane-4,5-5-dicarboxylic acid derivatives These compounds were synthesized by a liquid-phase synthetic method. A model of chick embryos dorsal root ganglion (DRG) cultures free of serum and a model of NG108-15 cell injured by H₂O₂ were applied to evaluate neurotropic activity of these target compounds Thus, 27 target compounds were synthesized. In cultured chick DRGs, N-[[(4R,5R)-5-[[(cyclohexyl)amino]carbonyl]-2,2-dimethyl-1,3-dioxolan-4-yl]carbonyl]-L-aspartic acid di-Et ester produced a little neurotrophic effect and promoted neurite outgrowth in vitro. In the model of H₂O₂-induced NG108 cell damage, N-[[(4R,5R)-2,2-dimethyl-5-[[(phenylmethyl)amino]carbonyl]-1,3-dioxolan-4-yl]carbonyl]-L-serine Et ester showed a significantly protective effect on an NG 108 cell.

Zhongguo Yaowu Huaxue Zazhi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

West, F. G. published the artcileApplications of Stevens [1,2]-Shifts of Cyclic Ammonium Ylides. A Route to Morpholin-2-ones, Synthetic Route of 101-98-4, the publication is Journal of Organic Chemistry (1994), 59(20), 6051-6, database is CAplus.

2-(N,N-Dialkylamino)ethyl diazoacetoacetates I (R¹ = benzyl, alkyl, etc.; R² = Me, benzyl) were prepared in two steps from ethanolamines. When heated in the presence of catalytic Cu, the substrates cleanly formed morpholinones II (same R¹, R²), presumably via the intermediacy of copper carbenoids and cyclic ammonium ylides. In most cases involving benzylic or allylic migrating groups, ylide [1,2]-shift occurred in good yield (55-80%). Simple alkyl groups failed to undergo the rearrangement, with the exception of a tert-Bu substituted compound, which furnished morpholinone II (R¹ = tert-Bu, R² = Me) in 10% yield.

Journal of Organic Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C17H16O2, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leyden, Donald E. published the artcileInversion of tertiary amines in aqueous acid, Quality Control of 101-98-4, the publication is Journal of the Chemical Society [Section] D: Chemical Communications (1969), 598, database is CAplus.

N,N-dibenzylmethylamine, N-benzyl-N-methyl-2-chloroethylamine, and N-benzyl-N-methylethanolamine were used for the study of the N inversion rate in aqueous solution Except in the high pH region, the rate of N inversion does not follow the predictions of the Saunders and Yamada equation (1963). In the intermediate pH region, the inversion rate is independent of pH. In the lower pH region, the rate is pH-dependent, but does not follow the S. and Y. equation.

Journal of the Chemical Society [Section] D: Chemical Communications published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leyden, Donald E. published the artcileProton exchange mechanisms of some tertiary benzylamines, Formula: C10H15NO, the publication is Journal of Physical Chemistry (1969), 73(9), 2924-9, database is CAplus.

The rate of proton exchange in aqueous HCl was measured for N,N-dibenzylmethylamine, N-benzyl-N-methylethanolamine, N-benzyl-N-methyl-2-chloroethylamine, and N,N-dimethylbenzylamine. The rate constant, kH, for the breaking of the R3N … HOH hydrogen bond was determined for each compound A factor influencing the value of kH is the H bonding between the protons in the water mol. and the aromatic rings.

Journal of Physical Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Haga, Yuji published the artcileDiscovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Bioorganic & Medicinal Chemistry (2011), 19(2), 883-893, database is CAplus and MEDLINE.

The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c (I), exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice.

Bioorganic & Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Osman, Maged A. published the artcileEpoxy-Layered Silicate Nanocomposites and Their Gas Permeation Properties, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Macromolecules (2004), 37(19), 7250-7257, database is CAplus.

Epoxy-OM (organo-montmorillonite) nanocomposites have been synthesized, and their permeability to oxygen and water vapor has been measured. The chem. structure of the organic monolayer ionically bonded to the montmorillonite surface has been varied, and its influence on the swelling, intercalation, and exfoliation behavior of the OM has been studied. Exfoliated aluminosilicate layers build a barrier for the permeating gas mols., while the polymer intercalated tactoids do not contribute much to the permeation barrier performance. The gas permeation through the composites was correlated to the volume fraction of the impermeable inorganic part of the OM. The incorporation of small volume fractions of the platelike nanoparticles in the polymer matrix decreased its permeability coefficient when the interface between the two heterogeneous phases was properly designed. Long alkyl chains enhanced the polymer intercalation but increased the permeability coefficient probably due to phase separation at the interface between the polymer and the inclusions. Matching the surface energy of the OM with that of the matrix as well as tethering polymer mols. to the silicate layers surface enhanced the exfoliation and decreased the permeation coefficient The exfoliation process is governed by interplay of entropic and energetic factors. A macroscopic volume average of the aspect ratio of montmorillonite platelets was deducted from the relative permeability of the nanocomposites by comparing the measured values to numerical predictions of gas permeation through composites of misaligned disk-shaped inclusions. The permeability coefficient of the epoxy matrix was reduced to one-fourth at 5 vol % Bz1OH loading, and the reduction was attributed to the tortuous pathway the gas mols. have to cover during their random walk to penetrate the composite. The transmission rate of water vapor through the composites is more influenced by the permeant-composite interactions and hence the hydrophobicity of the monolayer covering the inclusions surface. At 5 vol % BzC16 loading, the relative vapor transmission rate was reduced to half.

Macromolecules published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sheykhan, Mehdi published the artcileNovel access to carbonyl and acetylated compounds: the role of the tetra-n-butylammonium bromide/sodium nitrite catalyst, HPLC of Formula: 101-98-4, the publication is RSC Advances (2016), 6(56), 51347-51355, database is CAplus.

A novel aerobic oxidation of alcs. ArCH(OH)R (Ar = C₆H₅, 2-O₂N-3-CH₃-C₆H₃, 2-carbaldehydefuran-5-yl, etc.; R = H, CH₃) without the use of any oxidants was developed. An equimolar catalytic mixture of tetra-n-butylammonium bromide and sodium nitrite catalyzes the aerobic selective oxidation of benzylic alcs. under oxidant-free, base-free and metal-free conditions. The mild reaction conditions allow oxidation of a wide range of benzylic alcs., chemo-selectively to their carbonyl compounds ArC(O)R (68-93% isolated yields). More importantly, high selectivity among different kinds of alcs. (aromatic vs. aliphatic alcs., primary vs. secondary alcs. as well as alcs. having neutral rings vs. electron-deficient rings) is available by this approach. The method surprisingly switched over to be an efficient acetylation approach in the case of aliphatic alcs. without the use of any transition metal, phosphorus or other toxic reagents or any need for using toxic acyl halides, sulfonyl halides, anhydrides, etc. by the use of only acetic acid as a reagent.

RSC Advances published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C16H24BF4Ir, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts