Category: 101-98-4

Xue, Tong published the artcileResearch on an abnormal reaction of N-methyl-di(2-hydroxyethyl)amine, Formula: C10H15NO, the publication is Huaxue Tongbao (2015), 78(12), 1162-1165, database is CAplus.

In organic synthesis, methanesulfonyl chloride was often used to react with alc. to turn hydroxyl into a more active leaving group-methanesulfonyl. However, we had found that, when N-methyl-di(2-hydroxyethyl)amine reacted with methanesulfonyl chloride, its hydroxyl groups were both substituted by chlorine atoms. A series of designed experiments indicated that the key reason of this phenomenon was the generation of three-membered ring azonia ion transition state. The formation of this transition state must meet three requirements: there must two carbon atoms between the nitrogen atom and hydroxyl group, nitrogen atom must have sufficient electron cloud d. and the steric hindrance around nitrogen atom cannot be too high.

Huaxue Tongbao published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H10O2, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hasegawa, Tadashi published the artcileNovel biradical cyclization via remote-hydrogen transfer in photochemistry of 2-(dialkylamino)ethyl 3-benzoylacrylates, Computed Properties of 101-98-4, the publication is Bulletin of the Chemical Society of Japan (1993), 66(10), 3128-31, database is CAplus.

2-(Dibenzylamino)ethyl and 2-(benzylmethylamino)ethyl 3-benzoylacrylate underwent photocyclization via remote-proton transfer from their (Z)-forms competing with (E)-(Z) isomerization. The quantum yield for the cyclization when both (E)- and (Z)-isomers absorb the irradiating light was estimated to be 0.05 by applying the steady-state approximation

Bulletin of the Chemical Society of Japan published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Aihua published the artcileDrug discovery based on structure of FKBP52: design and synthesis of 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid derivatives and determination of their activity as neuroimmunophilin ligands, Synthetic Route of 101-98-4, the publication is Zhongguo Yaowu Huaxue Zazhi (2006), 16(6), 323-330, database is CAplus.

A method for the synthesis of the title compounds is reported here. One such 2-aza-bicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were investigated for their activity as neuroimmunophilin ligands. SYBYL/Composer was used for homol. modeling the structure of domain 1 (D1) of FKBP52 (a member of the FK506-binding family of immunophilins). Based on the structure of FKBP52D1, CADD (computer-aided drug design) was employed to design and virtually screen such novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives These compounds were synthesized by liquid-phase synthetic method. Cultured chick DRGs (dorsal root ganglion sensory neurons) was applied to evaluate neurotrophic activity of these target compounds Novel 2-azabicyclo[2.2.1]hept-5-ene-3-carboxy derivatives were designed based on the structure of FKBP52 and 21 target compounds were synthesized. In cultured chick DRGs, one compound produced potent neurotrophic effects and promoted neurite outgrowth in vitro.

Zhongguo Yaowu Huaxue Zazhi published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, AiHua published the artcileDrug discovery based on the structure of FKBP12: Design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Science in China, Series B: Chemistry (2007), 50(3), 405-417, database is CAplus.

By choosing neuroimmunophilin FKBP12 as a therapeutical target, the authors have attempted to discover a new structural drug for treating neurodegenerative disease. This drug should possess neurotrophic activity and not affect the immune system. Based on the crystal structure of FKBP12, FK506 and Calcineurin complex, small organic mols. were designed. These mols. were to have the ability of binding to FKBP12 in a virtual screening. By using a solution parallel synthetic method, these compounds were synthesized. The neuroprotective and neuroregenerative activities of these compounds were evaluated by binding assays, PC12 cells survival and neurite outgrowth model, chick dorsal root ganglion cultures (DRG) and 6-OHDA lesioned mice sympathetic nerve endings model. The evaluation results of these compounds showed that (2S)-2-[[[(3R)-4-(4-toluenesulfonyl)thiomorpholin-3-yl]carbonyl]amino]-4-methylpentanoic acid Et ester (N308) has great promise as a candidate for a neuroprotective and neuroregenerative agent.

Science in China, Series B: Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Ai Hua published the artcileDrug discovery based on the structure of FKBPs: design, synthesis and evaluation of L-1,4-thiazane-3-carboxylic acid derivatives as neuroimmunophilin ligands, Quality Control of 101-98-4, the publication is Chinese Chemical Letters (2005), 16(2), 163-166, database is CAplus.

Based on the structure of FK506, FKBP12 and calcineurin complex and the interactive characteristics of small mol. ligands with FK-506-binding proteins (FKBPs), a series of L-tetrahydro-1,4-thiazine-3-carboxylic acid derivatives I [X = O, R = PhCH₂NMeCH₂CH₂, PhCH:CHCH₂, 3-cyclohexylpropyl, 4-O₂NC₆H₄CH₂, etc.; X = NH, R = Me₂CHCH₂CH(CO₂Et), PhCH₂CH(CO₂CH₂Ph), etc.] was designed and synthesized as neuroimmunophilin ligands. The results of evaluation show that I [X = O; R = (PhCH₂OCH₂)₂CH] (N308) has a great promise as a candidate of neuroprotective and neuroregenerative agent.

Chinese Chemical Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Ping published the artcileAdvanced continuous flow platform for on-demand pharmaceutical manufacturing, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemistry – A European Journal (2018), 24(11), 2776-2784, database is CAplus and MEDLINE.

As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technol., herein we report a second-generation, reconfigurable and 25% smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards

Chemistry – A European Journal published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C12H17NO2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habtemariam, Abraha published the artcileControl of aminophosphine chelate ring-opening in Pt(II) and Pd(II) complexes: potential dual-mode anticancer agents, Formula: C10H15NO, the publication is Journal of the Chemical Society, Dalton Transactions (2001), 1306-1318, database is CAplus.

Bis(aminophosphine) complexes [M(R¹R²N(CH₂)_nPPh₂)₂]²⁺, M = Pt(II) or Pd(II), can exist in chelate ring-closed and ring-opened forms both in the solid state and in aqueous solution The equilibrium between them in solution can be controlled by the nature of the groups R¹ and R² (H, Me, Bz, cyclohexyl), by the bridge length n, and by the pH and Cl^– concentration X-ray crystal structures are reported for the ring-closed complexes cis-[Pt(H₂N(CH₂)₂PPh₂-P,N)₂]Cl₂, cis-[Pt(H₂N(CH₂)₃PPh₂-P,N)₂]Cl₂, and cis-[Pt(Me(H)N(CH₂)₂PPh₂-P,N)₂]Cl₂, the mono-ring-opened complex cis-Pd[(Me₂N(CH₂)₂PPh₂-N,P)Cl(Me₂NH(CH₂)₂PPh₂-P)](NO₃)₂, the di-ring-opened complex cis-[Pt(Me₂N(CH₂)₃PPh₂-P)₂Cl₂], and, for comparison, the monochelate cis-[Pd(Me₂N(CH₂)₃PPh₂-N,P)]Cl₂. These square-planar complexes exhibit varying degrees of distortion and variable M-N bond lengths dependent not only on the trans influence of P but also on steric effects within the complex. PH-induced chelate ring-opening of cis-[Pt(Me₂N(CH₂)₂PPh₂-P,N)₂]Cl₂ had an associated pK value of 6.9. In contrast, [M(R¹R²N(CH₂)_nPPh₂)₂]²⁺ complexes with R¹ and R² = H, n = 2 or 3 or R¹ = H and R² = Me, n = 2, are more difficult to ring-open. Thus cis-[Pt(Me(H)N(CH₂)₂PPh₂-P,N)₂]Cl₂ and cis-[Pt(H₂N(CH₂)₃PPh₂-P,N)₂]Cl₂ had associated pK values of 2.1 and 2.9, resp. These aminophosphine complexes may exhibit anticancer activity by two mechanisms: by disrupting mitochondrial membrane potentials as bis-chelated (ring-closed) lipophilic cations, or by direct binding to DNA bases as ring-opened complexes.

Journal of the Chemical Society, Dalton Transactions published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Azzena, Ugo published the artcileGeneration and reactivity of α-amino-substituted arylmethyllithium organometallics, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Tetrahedron (2000), 56(23), 3775-3780, database is CAplus.

Reductive cleavage of open chain and cyclic α-N,N-dialkylamino-substituted benzyl alkyl ethers with a dispersion of Li metal and a catalytic amount of naphthalene in THF allowed easy access to a wide array of α-N,N-dialkylamino-substituted benzyllithium derivatives Reaction of these organometallics with various electrophiles afforded the expected products in satisfactory yields.

Tetrahedron published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gagauzov, I. published the artcileDerivatives of 1,3-dimethylxanthine. I. Direct condensation of 1,3-dimethylxanthine with alkanolamines, Safety of 2-(Benzyl(methyl)amino)ethanol, the publication is Farmatsiya (Sofia, Bulgaria) (1977), 27(2), 1-6, database is CAplus.

Direct condensation of theophylline (I) with 1 equivalent HOCH₂CH2NRR¹ (R = Me, Et, Pr, Bu, CH₂CH₂CHMe₂, CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz; R¹ = CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz, CH₂CH₂O₂CH:CHPh) at 250-320° in a salt bath 50-90 min gave resinous II, which were taken up in EtOH and precipitated as the tartrates or saccharinates in 42-74% yield. The salts were H₂O-soluble and had bronchodilating, antihistaminic and diuretic effects, but were more toxic than I.

Farmatsiya (Sofia, Bulgaria) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Safety of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okimoto, Mitsuhiro published the artcileElectrooxidative cyclization of hydroxy amino compounds possessing a benzyl group, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Synthesis (2012), 44(9), 1315-1322, database is CAplus.

Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2-piperidinemethanols, resp., by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base.

Synthesis published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts