Category: 10083-24-6

Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure-activity relationships was written by Nuankaew, Wanlapa;Heemman, Armad;Wattanapiromsakul, Chatchai;Shim, Ji Heon;Kim, Na Woo;Yasmin, Tamanna;Jeong, Seo Yule;Nam, Youn Hee;Hong, Bin Na;Dej-adisai, Sukanya;Kang, Tong Ho. And the article was included in Journal of Natural Medicines in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

Senna siamea has been used as an antidiabetic drug since antiquity. With regard to traditional Thai medicine, the use of S. siamea was described for diabetes therapy. To understand the mol. mechanism regarding insulin resistance. Pure compounds were isolated from wood extract We studied their biol. activities on insulin-resistance using an in vivo zebrafish model. We also performed an in silico study; mol. docking, and in vitro study by taking advantage of the enzyme inhibitory activities of 伪-glucosidase, PTP1B, and DPP-IV. Based on the preliminary investigation that Et acetate and ethanol extracts have potent effects against insulin resistance on zebrafish larvae, five compounds were isolated from two fractions following: resveratrol, piceatannol, dihydropiceatannol, chrysophanol, and emodin. All of the isolated compounds had anti-insulin resistance effects on zebrafish larvae. Resveratrol, piceatannol, and dihydropiceatannol also demonstrated inhibitory effects against 伪-glucosidase. Chrysophanol and emodin inhibited PTP1B activity, while resveratrol showed a DPP-IV inhibition effect via the mol. docking. The results of enzyme assay were similar. In conclusions, S. siamea components demonstrated effects against insulin resistance. The chem. structure displayed identical biol. activity to that of the compounds Therefore, S. siamea wood extract and their components are potential therapeutic options in the treatment of diabetes. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Optimisation of microwave-assisted extraction and functional elucidation of bioactive compounds from Cola nitida pod was written by Olalere, Olusegun Abayomi;Gan, Chee-Yuen;Akintomiwa, Olumide Esan;Adeyi, Oladayo;Adeyi, Abiola. And the article was included in Phytochemical Analysis in 2021.HPLC of Formula: 10083-24-6 This article mentions the following:

The quality characteristics and stability of phenolic byproducts from Cola nitida wastes are critical factors for drug formulation and food nutraceutical applications. In this study, the effect of electromagnetic-based microwave-reflux extraction on the total phenolic content, antioxidant capacity, morphol. characteristics, physisorption and chromatog. phenolic profiles were successfully investigated. These physicochem. analyses are often employed in the standardisation of dried herbal and food nutraceutical products. In this study, the electromagnetic-based extraction process was optimized using the Box-Behnken design. The oleoresin bio-products were subsequently characterised to determine the total phenolic content, morphol. and microstructural degradation These analyses were conducted to elucidate the effect of the microwave heating on the C. nitida pod powder. From the predicted response, the optimal percentage yield was achieved at 26.20% under 5.39 min of irradiation time, 440 W microwave power and oven temperature of 55掳C. Moreover, the rapid estimation of the phenolic content and antioxidant capacity were recorded at 124.84 卤 0.064 mg gallic acid equivalent (GAE)/g dry weight (d.w.) and 6.93 卤 0.34渭g/mL, resp. The physicochem. characterization results from the Fourier-transform IR spectroscopy, field emission SEM and physisorption analyses showed remarkable changes in the micro-surface area (13.66%) characteristics. The recorded optimal conditions established a basis for future scale-up of microwave extraction parameters with a potential for maximum yield. The physiochem. characterization revealed the functional characteristics of C. nitida and their tolerance to microwave heating. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6HPLC of Formula: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cassane-type diterpenoids from Caesalpinia latisiliqua (Cav.) Hattink was written by Huyen, Le Thi;Son, Vu Hoang;Hau, Nguyen Thi Thu;Thu, Nguyen Thi Minh;Hoa, Truong Thi Viet;Hoang, Nguyen Huy;Cuc, Nguyen Thi;Tai, Bui Huu;Thao, Do Thi;Kiem, Phan Van;Nhiem, Nguyen Xuan. And the article was included in Phytochemistry Letters in 2022.Computed Properties of C14H12O4 This article mentions the following:

Three new cassane-type diterpenoids, namely caesalatic acids A-C (1 -3), and seven known compounds, resveratrol (4), piceatannol (5), aromadendrin (6), taxifolin (7), 3,4-dihydroxybenzaldehyde (8), Me gallate (9), and loliolide (10) were isolated from the methanol extract of the Caesalpinia latisiliqua (Cav.) Hattink leaves. Their chem. structures were elucidated by 1D- and 2D-NMR, MS data, CD, and compared with NMR data in the literature. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Computed Properties of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolomics reveals potential biomarkers of rice gall midge (Orseolia oryzae) interactions was written by Chen, Can;Zhang, Zong-qiong;Xia, Xiu-zhong;Yang, Xing-hai;Nong, Bao-xuan;Zhang, Xiao-li;Xu, Zhi-jian;Li, Dan-ting;Guo, Hui;Feng, Rui. And the article was included in Nanfang Nongye Xuebao in 2021.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

[Objective] To detect differential levels of metabolites between rice gall midge (RGM)-resistant and -susceptible rice materials to provide a theor. basis for analyzing rice-RGM interaction and assist in the development of green controls of RGM in rice. [Method] GXM-001-2 (high resistance) and TN1 (high susceptibility) were inoculated with RGM and liquid chromatog.-mass spectrometry was employed to detect changes in metabolite levels after 48 h. [Result] 330 metabolites were detected, of which 155 were known metabolites. TN1 displayed a much higher number of up-regulated metabolites after RGM infection than in GXM-001-2, where metabolites were largely down-regulated. The anal. of potential biochem. markers of rice infected by RGM showed that differentially regulated metabolites could be classified into four categories associated with resistance (n=16), susceptibility (n=16), infection (n=7) and host characteristics (n=3). Biochem. markers and fold change anal. showed that the resistance category included 1-aminocyclopropanicarboxylic acid, 3-phosphoglyceric acid, eicosanoic acid, 6-methylvitamin D, glutamic acid, phytol and tyrosine of which, the latter 4 were upregulated. Compounds associated with susceptibility included 2-hexketoic acid, 3-phenyllactic acid, 6-hydroxy hexanoic acid and other substances, of which 7 substances, including 6-hydroxy hexanoic acid, glucose and piceatannol, were downregulated. The characteristic compounds of infection included 4-aminobutyric acid, galactonic acid, propanedioic acid and adenine, uridine, propanedioic acid, and 纬-aminobutyric acid showed similar up or down trends in GXM-001-2 and TN1. The host characteristic substances consisted of isoleucine, hexadecanoic acid and cycloleucine, with the former two substances at significantly higher levels in GXM-001-2 relative to TN1 (P<0.05). [Conclusion] Under rice RGM condition, 16, 16, 7 and 3 metabolites associated with resistance, susceptibility, infection and host characteristics, resp., were selected. Of these, fatty acids and their derivatives (hexadecanoic acid, eicosanoic acid, tetradecanoic acid and 尾-hydroxytetradecanoic acid), amino acids (glutamic acid, tyrosine, phenylalanine and 纬-aminobutyric acid), phenolic acids (ferulic acid), terpenoids (phyllol) and amines (acetanilide, benzylamine and lactamide) are the most important potential biomarkers of RGM infection, which could play important roles in plant insect defense responses. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolomics insights into the mechanism by which Epichloe gansuensis endophyte increased Achnatherum inebrians tolerance to low nitrogen stress was written by Hou, Wenpeng;Wang, Jianfeng;Christensen, Michael J.;Liu, Jie;Zhang, Yongqiang;Liu, Yinglong;Cheng, Chen. And the article was included in Plant and Soil in 2021.Related Products of 10083-24-6 This article mentions the following:

Epichloe gansuensis increases the tolerance of host plants to abiotic stress. However, little is known about the mechanism by which E. gansuensis improves grass growth under low nitrogen availability stress. Achnatherum inebrians with E. gansuensis (E+) and without E. gansuensis (E-) were treated with modified 1/2 Hoagland containing 0.01 mM (low N) or 7.5 mM N (normal level) for 18 wk. After 18 wk of treatment with N, the dry weight of E+ and E- plants were measured, and the metabolomics anal. of leaves and roots grown under two different N concentrations was conducted with GS-MS to determine differential metabolites and metabolic pathways. E+ A. inebrians had higher dry weight of leaves and roots compared to the E- A. inebrians under low N stress. E. gansuensis increased the tolerance of A. inebrians to low N stress by its capability to increase the content of organic acids (salicylic acid and 3-hydroxypropionic acid) and glucose-6-phosphate in leaves, and E. gansuensis increased the content of fatty acids (linolenic acid and oleic acid) and amino acids (glycine and 4-aminobutyric acid) in roots under low N stress. Finally, E. gansuensis reprogramed the metabolic pathway of amino acids of host grasses to adapt to the different N concentration Our results reveal the chem. mechanism by which E. gansuensis enhances the tolerance of host grasses to low N, and provide the theor. basis for utilizing E. gansuensis, improving of grasses and crops, and for developing new germplasm for low-N tolerant grasses. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Related Products of 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Related Products of 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of Traditional and Modern Post-Harvest Withering Processes on the Composition of the Vitis v. Corvina Grape and the Sensory Profile of Amarone Wines was written by Tomasi, Diego;Lonardi, Andrea;Boscaro, Davide;Nardi, Tiziana;Marangon, Christine Mayr;De Rosso, Mirko;Flamini, Riccardo;Lovat, Lorenzo;Mian, Giovanni. And the article was included in Molecules in 2021.Synthetic Route of C14H12O4 This article mentions the following:

In the Valpolicella area (Verona, Italy) Vitis vinifera cv. Corvina is the main grape variety used to produce Amarone wine. Before starting the winemaking process, the Corvina grapes are stored in a withering (i.e., dehydrating) warehouse until about 30% of the berry weight is lost (WL). This practice is performed to concentrate the metabolites in the berry and enrich the Amarone wine in aroma and antioxidant compounds In compliance with the guidelines and strict Amarone protocol set by the Consorzio of Amarone Valpolicella, withering must be carried out by setting the grapes in a suitable environment, either under controlled relative air humidity (RH) conditions and wind speed (WS)-no temperature modification is to be applied-or, following the traditional methods, in non-controlled environmental conditions. In general, the two processes have different dehydration kinetics due to the different conditions in terms of temperature, RH, and WS, which affect the accumulation of sugars and organic acids and the biosynthesis of secondary metabolites such as stilbenes and glycoside aroma precursors. For this study, the two grape-withering processes were carried out under controlled (C) and non-controlled (NC) conditions, and the final compositions of the Corvina dried grapes were compared also to evaluate the effects on the organoleptic characteristics of Amarone wine. The findings highlighted differences between the two processes mainly in terms of the secondary metabolites of the dried grapes, which affect the organoleptic characteristics of Amarone wine. Indeed, by the sensory evaluation, wines produced by adopting the NC process were found more harmonious, elegant, and balanced. Finally, we can state how using a traditional system, grapes were characterised by higher levels of VOCs (volatile compounds), while wines had a higher and appreciable complexity and finesse. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Synthetic Route of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anti-Alzheimer鈥瞫 potential of different varieties of Piper betle leaves and molecular docking analyses of metabolites was written by Debnath, Mamita;Das, Susmita;Bhowmick, Shovonlal;Karak, Swagata;Saha, Achintya;De, Bratati. And the article was included in Free Radicals and Antioxidants in 2021.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Introduction: Acetylcholinesterase inhibitors are used to prevent symptoms of Alzheimer鈥瞫 disease which is initiated due to oxidative stress. Piper betle L. is a tropical evergreen perennial vine whose leaves are widely consumed as masticator in Asia and has medicinal properties. Objectives: The present study is aimed to investigate acetylcholinesterase inhibitory property of methanolic extracts of different varieties of Piper betle leaves and chemometrically identify different bioactive ingredients in vitro and in silico. Materials and Methods: Methanol extracts of the leaves collected in Feb. and Oct. from eight varieties of P. betle (Chhanchi, Bagerhati, Manikdanga, Kalibangla, Bangla, Ghanagete, Meetha and Haldi) were studied for acetylcholinesterase inhibitory properties. Chem. components were analyzed by Gas Chromatog. -Mass spectrometry and High Performance Thin Layer Chromatog. Active metabolites were identified chemometrically. The activities were proved in vitro and in silico. Results: All the extracts inhibited acetylcholinesterase. Statistical anal. suggested that several phenolic compounds were correlated to anti-cholinesterase activity. Piceatannol, hydroxychavicol, benzene-1,2,4-triol, and 4-methylcatechol are reported here to have such enzyme inhibitory properties. These four small mols. were further subjected to mol. docking anal. to explore their binding mechanism with the acetylcholinesterase enzyme. All the four small mols. are found to interact with the targeted enzyme in similar fashion like the mol. interactions observed for the standard inhibitor, Donepezil, at the active site of acetylcholiesterase. Conclusion: Thus, consumption of P. betle leaves may have a beneficial effect in the prevention and treatment of this neurodegenerative disease. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Passion fruit seed extract enriched in piceatannol obtained by microwave-assisted extraction was written by Silva, Gislaine C.;Rodrigues, Rodney A. F.;Bottoli, Carla B. G.. And the article was included in Sustainable Chemistry and Pharmacy in 2021.Electric Literature of C14H12O4 This article mentions the following:

Apart from being food, passion fruit (Passiflora edulis Sims) offers seeds to be used as an oil source, and the residual seed cake from oil extraction contains piceatannol, a mol. that can prevent skin damages. In this work, microwave-assisted extraction (MAE) was evaluated as a technique for the preparation of piceatannol-rich seed cake extracts, and its performance was compared to the conventional Soxhlet extraction MAE and Soxhlet exhibited different selectivities for the seed cake compounds A sequential MAE at 87掳C, with 70% EtOH, for 30 min each cycle, provided a fine brown powder with 27.17 卤 0.9渭g of piceatannol per mg of the extract, while Soxhlet extraction for 120 min resulted in a dark lumpy extract containing 13.03 卤 0.4渭g mg-1. Thus, MAE was shown to be a promising alternative to produce a passion fruit seed extract for cosmetic purposes, adding value to a residue from the passion fruit chain by providing a faster extraction and a more color friendly and easier-to-handle product with higher levels of piceatannol in comparison to the conventional method. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Electric Literature of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemical constituents of Cassia abbreviata and their anti-HIV-1 activity was written by Yang, Xianwen;He, Zhihui;Zheng, Yue;Wang, Ning;Mulinge, Martin;Schmit, Jean-Claude;Steinmetz, Andre;Seguin-Devaux, Carole. And the article was included in Molecules in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

Three new (1-3) and 25 known compounds were isolated from the crude extract of Cassia abbreviata. The chem. structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone (1) is the first heterodimer of guibourtinidol and planchol A. Compound 2 was a new chalcane, while 3 was a new naphthalene. Cassiabrevone (1), guibourtinidol-(4伪鈫?)-epiafzelechin (4), taxifolin (8), oleanolic acid (17), piceatannol (22), and palmitic acid (28), exhibited potent anti-HIV-1 activity with IC₅₀ values of 11.89 渭M, 15.39 渭M, 49.04 渭M, 7.95 渭M, 3.58 渭M, and 15.97 渭M, resp. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cassane-type diterpenoids from Caesalpinia latisiliqua (Cav.) Hattink was written by Huyen, Le Thi;Son, Vu Hoang;Hau, Nguyen Thi Thu;Thu, Nguyen Thi Minh;Hoa, Truong Thi Viet;Hoang, Nguyen Huy;Cuc, Nguyen Thi;Tai, Bui Huu;Thao, Do Thi;Kiem, Phan Van;Nhiem, Nguyen Xuan. And the article was included in Phytochemistry Letters in 2022.Computed Properties of C14H12O4 This article mentions the following:

Three new cassane-type diterpenoids, namely caesalatic acids A-C (1 -3), and seven known compounds, resveratrol (4), piceatannol (5), aromadendrin (6), taxifolin (7), 3,4-dihydroxybenzaldehyde (8), Me gallate (9), and loliolide (10) were isolated from the methanol extract of the Caesalpinia latisiliqua (Cav.) Hattink leaves. Their chem. structures were elucidated by 1D- and 2D-NMR, MS data, CD, and compared with NMR data in the literature. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Computed Properties of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts