Category: 100751-63-1

Electric Literature of 100751-63-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

c. 6-Bromo-2-naphthaldehyde To a solution of 6-bromo-2-naphthylmethyl alcohol (6.71 g, 28.3 mmol) in CH2Cl2 (350 mL) was added pyridinium chlorochromate (6.71 g, 31.13 mmol) all at once. The mixture visually went from orange-red to black over 30 minutes and 150 mL of ether was added. The black mixture was passed through a silica gel column and eluted with ether. The solvents were evaporated and the solid was further purified on silica gel (hexane:CH2Cl2 1:1) to give 6.25 g of 6-bromo-2-naphthaldehyde (94%) as a white solid. %). 1H NMR (300 MHz; CDCl3): delta7.65 (dd, J1=2.0 Hz, J2=9.0 Hz, 1 H); 7.84 (t, J=8.0 Hz, 2 H); 7.97 (dd, J1=2.0 Hz, J2=8.0 Hz, 1 H); 8.06 (d, J=2.0 Hz, 1 H); 8.29 (s, 1 H); 10.14 (s, 1 H); 13C NMR (300 MHz; CDCl3): ppm 123.5, 123.9, 128.0, 130.1, 130.5, 130.8, 130.9, 133.9, 134.2, 137.1, 191.6.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100751-63-1, 6-Bromo-2-naphthylmethanol.

Reference:
Patent; Pfahl, Magnus; Tachdjian, Catherine; Al-Shamma, Hussien A.; Fanjul, Andrea; Pleynet, David P.M.; Spruce, Lyle W.; Wiemann, Torsten R.; Ibarra, Jason B.; US2002/143182; (2002); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C11H9BrO

stirring to (6-bromonaphthalen-2-yl)methanol (18.1 g, 76.7 mmol, 1.00 eq.) at 0 CPCC (34.6 g, 92.0 mmol, 1.20 eq.) was added portionwise in DCM (300 mL).The mixture was stirred at room temperature for 16 hours and then filtered.The filtrate was concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether: DCM = 10-70%).6-Bromonaphthalene-2-carbaldehyde (12.8 g, a two-step yield of 68%) was obtained as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 100751-63-1.

Reference:
Patent; Huazhong University of Science and Technology; Zhu Mingqiang; Wang Yalong; Li Chong; Fan Cheng; (28 pag.)CN108530392; (2018); A;,
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Electric Literature of 100751-63-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100751-63-1, name is 6-Bromo-2-naphthylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

3.47a (6-iodo-naphthalen-2-yl)-methanol Prepared according to general working method II from (6-bromo-naphthalen-2-yl)-methanol (500 mg, 2.11 mmol). Yield: 450 mg (75.1% of theory). C11H9IO (M=284.10).

According to the analysis of related databases, 100751-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boehringer Ingelheim Pharma GmbH & Co. KG; US2004/209865; (2004); A1;,
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Adding a certain compound to certain chemical reactions, such as: 100751-63-1, 6-Bromo-2-naphthylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 100751-63-1, blongs to alcohols-buliding-blocks compound. SDS of cas: 100751-63-1

A mixture of the product from Example 1A (0.119 g, 0.50 mmol), 4 cyanophenylboronic acid (0.088 g, 0.60 mmol, 1.2 equiv.), PdCl2(PPh3)2 (7 mg, 0.001 mmol, 0.020 equiv.) and K3PO4H2O (288 mg, 1.5 mmol, 3.0 equiv.) in isopropanol (10 ML) and distilled water (4 ML) was stirred at 50 C. under a dry nitrogen atmosphere for 1.5 hr.The reaction mixture was cooled to room temperature then concentrated under reduced pressure.The residue was partitioned between ethyl acetate and saturated aqueous NH4Cl. The organic layer was dried (MgSO4), and filtered.The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (65:35 hexane/ethyl acetate).Fractions containing product were combined and concentrated under reduced pressure to provide the product as a white solid (95 mg, 73% yield). M.p. 174.1-175.5 C. 1H NMR (CDCl3, 300 MHz) delta 8.06 (d, J=2 Hz, 1H), 7.97-7.70 (m, 8H), 7.54 (dd, J=2, 12 Hz, 1H), 4.90 (dbr, J=6 Hz, 2H), 1.78 (tbr, J=6 Hz, 1H). MS (DCl-NH3) [M+NH4]+ at 277, [M+NH4 NH3]+ at 294.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100751-63-1, 6-Bromo-2-naphthylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; Altenbach, Robert J.; Black, Lawrence A.; Chang, Sou-Jen; Cowart, Marlon D.; Faghih, Ramin; Gfesser, Gregory A.; Ku, Yi-yin; Liu, Huaqing; Lukin, Kirill A.; Nersesian, Diana L.; Pu, Yu-ming; Sharma, Padam N.; Bennani, Youssef L.; US2004/92521; (2004); A1;,
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Application of 100751-63-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, the compound obtained in the second step to the reactor (T-3) was charged (23.6 g, 99.6 mmol) and methylene chloride (250ml). The solution was cooled to 0 , and Dess-Martin periodinane; was added in portions (DMP 42.2g, 99.6mmol) to 3 times. The mixture was stirred for a further 2 hours while returning to room temperature. The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (300 ml), then was subjected to filtration, the filtrate was extracted with ethyl acetate. The organic layers were washed with water, aqueous sodium sulfite, and washed sequentially with water and saturated brine, and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure, the residue was purified by silica gel chromatography (eluent: toluene) to give the compound (T-4) (19.05g, 81.0mmol; 81%) was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100751-63-1, 6-Bromo-2-naphthylmethanol.

Reference:
Patent; JNC CORPORATION; JNC PETROCHEMICAL CORPORATION; GOTO, MAYUMI; TANAKA, HIROYUKI; (104 pag.)JP2016/37458; (2016); A;,
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Electric Literature of 100751-63-1, Adding some certain compound to certain chemical reactions, such as: 100751-63-1, name is 6-Bromo-2-naphthylmethanol,molecular formula is C11H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100751-63-1.

To a solution of (6-bromonaphtbalen-2-yl)methanol (0.7 g, 2.97 mmol) in dichloromethane (20mL) was added TBSCI (667 mg, 4.45 mmol) and imidazole (302 mg, 4.45 mmol). After theaddition, the reaction mixture was stirred at 25 C for 1 h. The reaction was then quenched by addition of saturated aqueous NI-l4Cl (20 mE) and extracted with ethyl acetate (3 x 30 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica-gel chromatography (petroleum ether: ethyl acetate = 30: 1) togive the title compound (0.8 g, 77 % yield) as a colorless oil.

According to the analysis of related databases, 100751-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
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Synthetic Route of 100751-63-1 , The common heterocyclic compound, 100751-63-1, name is 6-Bromo-2-naphthylmethanol, molecular formula is C11H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(6-bromo-naphthalen-2-yl)-methanol (0.307 g, 1.29 mmol) obtained in Preparation Example 102 was dissolvedin 5 mL of acetonitrile. Thionyl-chloride (0.188 mL, 2.59 mmol) was added thereto at 0C, and the mixture was stirredat room temperature for 1 hour. The reaction solution was distilled under reduced pressure and purified by columnchromatography to obtain the title compound (0.248 g, 75%).1H-NMR (CDCl3) delta 8.00 (1H, s), 7.83-7.68 (3H, m), 7.58-7.53 (2H, m), 4.73 (2H, s).

The synthetic route of 100751-63-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
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