Category: 1004-24-6

Adding a certain compound to certain chemical reactions, such as: 1004-24-6, (4-Methylenecyclohexyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-24-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H14O

PREPARATION 8 4-Methylenecyclohexane-1-carbaldehyde To pydridinium dichromate (223 g., 0.59 mole) in 1 liter CH2 Cl2, stirring under N2, was added dropwise 4-methylene-1-cyclohexanemethanol (50 g., 0.40 mole) in 75 ml. CH2 Cl2 over a few minutes. After stirring for 21 hours at room temperature, the reaction mixture was heated at 60 C. for 24 hours. The reaction mixture was cooled, diluted with 400 ml. ether and decanted from solids. The solids were slurried with 400 ml. of fresh ether and decanted. The combined organic decants were filtered over fluorasil and diatomaceous earth and the filtrate concentrated in vacuo to an oil (41 g.) and distilled to yield title product, 13.6 g., b.p. 82-90/15-20 mm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-24-6, its application will become more common.

Reference:
Patent; Pfizer Inc.; US4430337; (1984); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1004-24-6, name is (4-Methylenecyclohexyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C8H14O

To a solution of (4-methylenecyclohexyl)methanol (1.1 g, 8.72 mmol) in acetonitrile (40 mL) was added a mixture of iodine (3.32 g, 13.07 mmol) in acetonitrile (120 mL) at 0 C. The reaction mixture was stirred at 0 C for 3 h. The reaction mixture was diluted with EtOAc and washed with aq. solution of Na2S203, IN NaOH, brine, dried (MgS04) and purified on a 40 g silica gel cartridge(EtOAc/hexane: 0 to 20%) to afford the product (0.53g, 24%). 1H NMR (400MHz, CHLOROFORM-d) ppm 3.94 (s, 2H), 3.14 (s, 2H), 2.01 – 1.93 (m, 2H), 1.90 – 1.80 (m, 2H), 1.75 – 1.66 (m, 5H).

The synthetic route of 1004-24-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HEWAWASAM, Piyasena; LOPEZ, Omar D.; TU, Yong; WANG, Alan Xiangdong; XU, Ningning; KADOW, John F.; MEANWELL, Nicholas A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; KUMAR, Indasi J. Gopi; PUNUGUPATI, Suresh Kumar; BELEMA, Makonen; WO2015/5901; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts