Tai, Cheng-An et al. published their research in Journal of Organic Chemistry in 2003 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H14O6

Facile Cu(OTf)2-Catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-Pot Anomeric Substitution to Thioglycosides under Solvent-Free Conditions was written by Tai, Cheng-An;Kulkarni, Suvarn S.;Hung, Shang-Cheng. And the article was included in Journal of Organic Chemistry in 2003.Formula: C6H14O6 This article mentions the following:

Solvent-free per-O-acetylation of hexoses with a stoichiometric amount of acetic anhydride employing 0.03 mol % Cu(OTf)2 proceeded in high yields (90-99%) at room temperature to give exclusively pyranosyl products as an anomeric mixture, the 伪/尾 ratio of which was dependent on the temperature and amount of catalyst used. Sequential anomeric substitution with p-thiocresol in the presence of BF3路etherate gave the thioglycosides, isolated exclusively or predominantly as one anomer in 66-75% yields. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gorrec, Fabrice et al. published their research in Acta Crystallographica, Section F: Structural Biology Communications in 2015 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 10030-85-0

The MORPHEUS II protein crystallization screen was written by Gorrec, Fabrice. And the article was included in Acta Crystallographica, Section F: Structural Biology Communications in 2015.Reference of 10030-85-0 This article mentions the following:

High-quality macromol. crystals are a prerequisite for the process of protein structure determination by X-ray diffraction. Unfortunately, the relative yield of diffraction-quality crystals from crystallization experiments is often very low. In this context, innovative crystallization screen formulations are continuously being developed. In the past, MORPHEUS, a screen in which each condition integrates a mix of additives selected from the Protein Data Bank, a cryoprotectant and a buffer system, was developed. Here, MORPHEUS II, a follow-up to the original 96-condition initial screen, is described. Reagents were selected to yield crystals when none might be observed in traditional initial screens. Besides, the screen includes heavy atoms for exptl. phasing and small polyols to ensure the cryoprotection of crystals. The suitability of the resulting novel conditions is shown by the crystallization of a broad variety of protein samples and their efficiency is compared with com. available conditions. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Reference of 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jubiao et al. published their research in Synthetic Communications in 2004 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C6H14O6

Synthesis of Trisaccharide of Incanoside from Caryopteris incana was written by Li, Jubiao;Wang, Yanguang. And the article was included in Synthetic Communications in 2004.Formula: C6H14O6 This article mentions the following:

Trisaccharide Ph 2,3,4,6-tetra-O-acetyl-尾-D-glucopyranosyl-(1鈫?)-3,4-di-O-benzoyl-伪-L-rhamnopyranosyl-(1鈫?)-2-O-acetyl-4,6-O-benzylidene-1-thio-尾-D-glucopyranoside, the sugar core of incanosides from Caryopteris incana, was synthesized via a concise route. The key step of this route involved the preparation of decisive disaccharide acceptor from the Ph 2-acetyl-3,4-di-O-benzoyl-伪-L-rhamnopyranosyl-(1鈫?)-2-O-acetyl-4,6-O-benzylidene-1-thio-尾-D-glucopyranoside by regioselective and chemoselective deacetylation method. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng-Lund, Helena et al. published their research in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2019 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Exploring the chemical space for freeze-drying excipients was written by Meng-Lund, Helena;Holm, Tobias Palle;Poso, Antti;Jorgensen, Lene;Rantanen, Jukka;Grohganz, Holger. And the article was included in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2019.Category: alcohols-buliding-blocks This article mentions the following:

Commonly, a limited number of generally accepted bulking agents and lyoprotectants are used for freeze-drying; predominantly mannitol, glycine, sucrose and trehalose. The purpose of this study was to combine a theor. approach using mol. descriptors with a large scale exptl. screening to evaluate the suitability of a broad range of excipients for freeze-drying. A large selection of sugars, polyols and amino acids was characterized by modulated differential scanning calorimetry (mDSC) and X-ray powder diffraction (XRPD) after well-plate based freeze-drying. The calculated mol. descriptors were investigated with both hierarchical cluster anal. and principal component anal. A clear clustering of the excipients according to the size-related and weight-related descriptors was observed; however other relevant descriptors could also be identified. From a practical perspective, a trend was observed with regard to a higher likelihood for amorphization and a higher glass transition temperature of the maximally freeze-concentrated solution with increasing mol. size. A translation of the mol. descriptors on pharmaceutical performance was more successful for lyoprotectants than for bulking agents. Addnl., in the course of the exptl. screening, several new potential bulking agents and lyoprotectants were identified. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Category: alcohols-buliding-blocks).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aspinall, G. O. et al. published their research in Journal of the Chemical Society in 1958 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 10030-85-0

Gum ghatti (Indian gum). III. Neutral oligosaccharides formed on partial acid hydrolysis of the gum was written by Aspinall, G. O.;Auret, Barbara J.;Hirst, E. L.. And the article was included in Journal of the Chemical Society in 1958.Related Products of 10030-85-0 This article mentions the following:

Gum ghatti (100 g.) in 1.95 l. H2O was heated to 100掳, 50 ml. 4N H2SO4 added, and the solution boiled 1.5 hrs. The cooled solution was neutralized with Ba(OH)2 and BaCO3, filtered, concentrated to 400 ml., and poured into 2 l. EtOH. The precipitated degraded polysaccharide A (I) (50 g.) was separated and the liquor concentrated to 200 ml., passed through Amberlite IR-120 (H) and IR-4B (OH), and conced. to 35 g. sirup B (II). I was hydrolyzed again to give a further 15 g. II. II (50 g.) in 200 ml. H2O was chromatographed on 800 g. 1:1 C-Celite. Elution with H2O gave 36 g. monosaccharides [arabinose (III), galactose (IV), xylose, and rhamnose (trace)] and a small fraction (0.8 g.) which gave L-rhamnose hydrate, m. 90-1掳 [伪]D -2掳. Oligosaccharides were eluted with EtOHH2O. Chromatography of fraction 1 (0.23 g.) showed 6-(O-尾-galactopyranosyl)galactose (V), 3-(O-尾-arabopyranosyl)arabinose (VI) and a pentose-containing disaccharide. Hydrolysis of the mixture gave III and IV. Fraction 2 (1.1 g.) was chromatographed on cellulose with 10:4:3 EtOAc-C5H5N-H2O to give 0.15 g. of mixture III, IV and arabinose-containing disaccharides and 0.56 g. sirup B, [伪]D 31掳. Methylation of 200 mg. II followed by hydrolysis and chromatography on cellulose with 7:3 pert. ether-BuOH gave 40 mg. 2,3,4,6-tetra-O-methyl-D-galactose (VII) (aniline derivative, m. 198掳), 35 mg. mixture of VII and 2,3,4-tri-O-methylgalactose (VIII), and 39 mg. VIII (aniline derivative, m. 159-60掳). Fraction 3 (205 mg.) chromatographed on cellulose gave 65 mg. mixture III, IV and three III-containing disaccharides, 10 mg. VI, 30 mg. disaccharide, [伪]D 125掳, which hydrolyzed to IV and glucose, and 50 mg. V. Fraction 4 gave 155 mg. sugar (IX), m. 202-3掳 [伪]D 80掳. Methylation of 100 mg. IX followed by hydrolysis and chromatography on cellulose gave 28 mg. VII with a trace of 2,5-di-O-methylarabinose (X), 5 mg. X, 10 mg. tri-O-methylgalactose, 2,4-di-O-methylarabinose (XI), and 20 mg. XI, [伪]D 120掳. Fraction 5 (80 mg.) separated on cellulose gave 25 mg. mixture of III-containing disaccharides, 5 mg. 3-(O-尾-galactopyranosyl)arabinose (XII), 25 mg. 3-(O-尾-D-galactopyranosyl)-D-galactose, m. 151-2掳, [伪]D 69掳, and 3 mg. V. Chromatography of 0.58 g. fraction 6 (0.83 g.) on cellulose gave 0.45 g. trisaccharide (XIII), [伪]D 20掳, and traces of V and monosaccharides. Partial and complete hydrolysis of XIII gave V and IV, resp. Methylation of 200 mg. XIII followed by hydrolysis gave 36 mg. VII and 80 mg. VIII. Fraction 7 gave 265 mg. trisaccharide (XIV), m. 191掳, [伪]D 39掳. Partial hydrolysis of XIV gave III, IV, XII, and V. Methylation of 200 mg. XIV followed by hydrolysis gave 47 mg. VII, 5 mg. X (2,5-di-O-methyl-L-arabonamide, m. 122掳), 40 mg. VIII, and 32 mg. XI. Fraction 8 contained 0.47 g. sugar, [伪]D 14掳, which on partial hydrolysis gave V. Fraction 9 gave 100 mg. tetrasaccharide, m. 171掳, [伪]D 26掳, which on partial hydrolysis gave III, IV, XII, and V. Fraction 10 gave a sugar, m. 177-9掳 (decomposition), [伪]D 19掳, which on partial hydrolysis gave III, IV, XII, and V. Thus, the first 3 members of the series O-(尾-D-galactopyranosyl)-[(1 鈫?6)-O-(尾-D-galactopyranosyl)]n-(1 鈫?6)-D-galactose (n = 0, 1, 2) and the first 4 members of the series O-(尾-D-galactopyranosyl)-[(1 鈫?6)-O-(尾-D-galactopyranosyl)]n-(1 鈫?3)-L-arabinose (n = 0, 1, 2, 3) have been characterized. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Related Products of 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tai, Cheng-An et al. published their research in Journal of Organic Chemistry in 2003 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H14O6

Facile Cu(OTf)2-Catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-Pot Anomeric Substitution to Thioglycosides under Solvent-Free Conditions was written by Tai, Cheng-An;Kulkarni, Suvarn S.;Hung, Shang-Cheng. And the article was included in Journal of Organic Chemistry in 2003.Formula: C6H14O6 This article mentions the following:

Solvent-free per-O-acetylation of hexoses with a stoichiometric amount of acetic anhydride employing 0.03 mol % Cu(OTf)2 proceeded in high yields (90-99%) at room temperature to give exclusively pyranosyl products as an anomeric mixture, the α/β ratio of which was dependent on the temperature and amount of catalyst used. Sequential anomeric substitution with p-thiocresol in the presence of BF3·etherate gave the thioglycosides, isolated exclusively or predominantly as one anomer in 66-75% yields. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gorrec, Fabrice et al. published their research in Acta Crystallographica, Section F: Structural Biology Communications in 2015 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 10030-85-0

The MORPHEUS II protein crystallization screen was written by Gorrec, Fabrice. And the article was included in Acta Crystallographica, Section F: Structural Biology Communications in 2015.Reference of 10030-85-0 This article mentions the following:

High-quality macromol. crystals are a prerequisite for the process of protein structure determination by X-ray diffraction. Unfortunately, the relative yield of diffraction-quality crystals from crystallization experiments is often very low. In this context, innovative crystallization screen formulations are continuously being developed. In the past, MORPHEUS, a screen in which each condition integrates a mix of additives selected from the Protein Data Bank, a cryoprotectant and a buffer system, was developed. Here, MORPHEUS II, a follow-up to the original 96-condition initial screen, is described. Reagents were selected to yield crystals when none might be observed in traditional initial screens. Besides, the screen includes heavy atoms for exptl. phasing and small polyols to ensure the cryoprotection of crystals. The suitability of the resulting novel conditions is shown by the crystallization of a broad variety of protein samples and their efficiency is compared with com. available conditions. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Reference of 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jubiao et al. published their research in Synthetic Communications in 2004 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C6H14O6

Synthesis of Trisaccharide of Incanoside from Caryopteris incana was written by Li, Jubiao;Wang, Yanguang. And the article was included in Synthetic Communications in 2004.Formula: C6H14O6 This article mentions the following:

Trisaccharide Ph 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl-(1→2)-3,4-di-O-benzoyl-α-L-rhamnopyranosyl-(1→3)-2-O-acetyl-4,6-O-benzylidene-1-thio-β-D-glucopyranoside, the sugar core of incanosides from Caryopteris incana, was synthesized via a concise route. The key step of this route involved the preparation of decisive disaccharide acceptor from the Ph 2-acetyl-3,4-di-O-benzoyl-α-L-rhamnopyranosyl-(1→3)-2-O-acetyl-4,6-O-benzylidene-1-thio-β-D-glucopyranoside by regioselective and chemoselective deacetylation method. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng-Lund, Helena et al. published their research in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2019 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Exploring the chemical space for freeze-drying excipients was written by Meng-Lund, Helena;Holm, Tobias Palle;Poso, Antti;Jorgensen, Lene;Rantanen, Jukka;Grohganz, Holger. And the article was included in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2019.Category: alcohols-buliding-blocks This article mentions the following:

Commonly, a limited number of generally accepted bulking agents and lyoprotectants are used for freeze-drying; predominantly mannitol, glycine, sucrose and trehalose. The purpose of this study was to combine a theor. approach using mol. descriptors with a large scale exptl. screening to evaluate the suitability of a broad range of excipients for freeze-drying. A large selection of sugars, polyols and amino acids was characterized by modulated differential scanning calorimetry (mDSC) and X-ray powder diffraction (XRPD) after well-plate based freeze-drying. The calculated mol. descriptors were investigated with both hierarchical cluster anal. and principal component anal. A clear clustering of the excipients according to the size-related and weight-related descriptors was observed; however other relevant descriptors could also be identified. From a practical perspective, a trend was observed with regard to a higher likelihood for amorphization and a higher glass transition temperature of the maximally freeze-concentrated solution with increasing mol. size. A translation of the mol. descriptors on pharmaceutical performance was more successful for lyoprotectants than for bulking agents. Addnl., in the course of the exptl. screening, several new potential bulking agents and lyoprotectants were identified. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Category: alcohols-buliding-blocks).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aspinall, G. O. et al. published their research in Journal of the Chemical Society in 1958 | CAS: 10030-85-0

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 10030-85-0

Gum ghatti (Indian gum). III. Neutral oligosaccharides formed on partial acid hydrolysis of the gum was written by Aspinall, G. O.;Auret, Barbara J.;Hirst, E. L.. And the article was included in Journal of the Chemical Society in 1958.Related Products of 10030-85-0 This article mentions the following:

Gum ghatti (100 g.) in 1.95 l. H2O was heated to 100°, 50 ml. 4N H2SO4 added, and the solution boiled 1.5 hrs. The cooled solution was neutralized with Ba(OH)2 and BaCO3, filtered, concentrated to 400 ml., and poured into 2 l. EtOH. The precipitated degraded polysaccharide A (I) (50 g.) was separated and the liquor concentrated to 200 ml., passed through Amberlite IR-120 (H) and IR-4B (OH), and conced. to 35 g. sirup B (II). I was hydrolyzed again to give a further 15 g. II. II (50 g.) in 200 ml. H2O was chromatographed on 800 g. 1:1 C-Celite. Elution with H2O gave 36 g. monosaccharides [arabinose (III), galactose (IV), xylose, and rhamnose (trace)] and a small fraction (0.8 g.) which gave L-rhamnose hydrate, m. 90-1° [α]D -2°. Oligosaccharides were eluted with EtOHH2O. Chromatography of fraction 1 (0.23 g.) showed 6-(O-β-galactopyranosyl)galactose (V), 3-(O-β-arabopyranosyl)arabinose (VI) and a pentose-containing disaccharide. Hydrolysis of the mixture gave III and IV. Fraction 2 (1.1 g.) was chromatographed on cellulose with 10:4:3 EtOAc-C5H5N-H2O to give 0.15 g. of mixture III, IV and arabinose-containing disaccharides and 0.56 g. sirup B, [α]D 31°. Methylation of 200 mg. II followed by hydrolysis and chromatography on cellulose with 7:3 pert. ether-BuOH gave 40 mg. 2,3,4,6-tetra-O-methyl-D-galactose (VII) (aniline derivative, m. 198°), 35 mg. mixture of VII and 2,3,4-tri-O-methylgalactose (VIII), and 39 mg. VIII (aniline derivative, m. 159-60°). Fraction 3 (205 mg.) chromatographed on cellulose gave 65 mg. mixture III, IV and three III-containing disaccharides, 10 mg. VI, 30 mg. disaccharide, [α]D 125°, which hydrolyzed to IV and glucose, and 50 mg. V. Fraction 4 gave 155 mg. sugar (IX), m. 202-3° [α]D 80°. Methylation of 100 mg. IX followed by hydrolysis and chromatography on cellulose gave 28 mg. VII with a trace of 2,5-di-O-methylarabinose (X), 5 mg. X, 10 mg. tri-O-methylgalactose, 2,4-di-O-methylarabinose (XI), and 20 mg. XI, [α]D 120°. Fraction 5 (80 mg.) separated on cellulose gave 25 mg. mixture of III-containing disaccharides, 5 mg. 3-(O-β-galactopyranosyl)arabinose (XII), 25 mg. 3-(O-β-D-galactopyranosyl)-D-galactose, m. 151-2°, [α]D 69°, and 3 mg. V. Chromatography of 0.58 g. fraction 6 (0.83 g.) on cellulose gave 0.45 g. trisaccharide (XIII), [α]D 20°, and traces of V and monosaccharides. Partial and complete hydrolysis of XIII gave V and IV, resp. Methylation of 200 mg. XIII followed by hydrolysis gave 36 mg. VII and 80 mg. VIII. Fraction 7 gave 265 mg. trisaccharide (XIV), m. 191°, [α]D 39°. Partial hydrolysis of XIV gave III, IV, XII, and V. Methylation of 200 mg. XIV followed by hydrolysis gave 47 mg. VII, 5 mg. X (2,5-di-O-methyl-L-arabonamide, m. 122°), 40 mg. VIII, and 32 mg. XI. Fraction 8 contained 0.47 g. sugar, [α]D 14°, which on partial hydrolysis gave V. Fraction 9 gave 100 mg. tetrasaccharide, m. 171°, [α]D 26°, which on partial hydrolysis gave III, IV, XII, and V. Fraction 10 gave a sugar, m. 177-9° (decomposition), [α]D 19°, which on partial hydrolysis gave III, IV, XII, and V. Thus, the first 3 members of the series O-(β-D-galactopyranosyl)-[(1 → 6)-O-(β-D-galactopyranosyl)]n-(1 → 6)-D-galactose (n = 0, 1, 2) and the first 4 members of the series O-(β-D-galactopyranosyl)-[(1 → 6)-O-(β-D-galactopyranosyl)]n-(1 → 3)-L-arabinose (n = 0, 1, 2, 3) have been characterized. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Related Products of 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts