Category: 100-86-7

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-86-7, name is 2-Methyl-1-phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C10H14O

REFERENCE EXAMPLE 2 1,3,3-trimethyl-3,4-dihydroisoquinolin To conc. sulfuric acid (10 ml) was added a solution of 2-methyl-1-phenylpropan-2-ol (7.0 g) and acetonitrile (1.62 ml) in benzene (7.0 ml) dropwise and the mixture was stirred for 24 hours at room temperature.The mixture was neutralized by adding to a mixture of ice and a saturated aqueous solution of sodium bicarbonate dropwise, and it was extracted with ethyl acetate twice.The extract was dried over anhydrous magnesium sulfate and was concentrated under reduced pressure.The residue was dissolved in ether and was extracted with 1 N hydrochloric acid and 2N hydrochloric acid.The extract was washed with ether and to the mixture was added 5N aqueous solution of sodium hydroxide and was extracted with ether twice.The extract was washed with water and a saturated aqueous solution of sodium chloride successively, and dried over anhydrous magnesium sulfate and was concentrated under reduced pressure to give the title compound (2.53 g) having the following physical data. TLC: Rf 0.22 (hexane:ethyl acetate=2:1); NMR (CDCl3): delta 7.48 (dd, J=7.5, 1.5 Hz, 1H), 7.35 (dt, J=1.5, 7.5 Hz, 1H), 7.30-7.25 (m, 1H), 7.14 (d, J=7.5 Hz, 1H), 2.69 (s, 2H), 2.38 (s, 3H), 1.20 (s, 6H).

With the rapid development of chemical substances, we look forward to future research findings about 100-86-7.

Reference:
Patent; Ogawa, Mikio; Takaoka, Yoshikazu; Ohhata, Akira; US2004/77643; (2004); A1;,
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100-86-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-86-7, name is 2-Methyl-1-phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

For the tetrahydropyanylation or trimethylsilylation of alcohols, to solution of the DHP(1 mmol) or HMDS(1 mmol) in CH3CN (5ml) were added {K*18-crown-6]Br3}n (0.001 mmol). The solution was stirred at room temperature for 1 min. Then alcohol(1 mmol for THP and 2 mmolf for TMS) was stirred at room temperature for an appropriate time (Table 2). After completion of the reaction, CH3CN was removed by water bath distillation. To the residue was added n-hexane or ethyl acetate(5 ml) and the mixture was filtered (the catalyst is insoluble in n-hexane and ethyl acetate). The filtrate was wahed with n-hexane or ethyl acetate (10 ml*2). The solvent was removed by distillation to yield pure products.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-86-7, 2-Methyl-1-phenyl-2-propanol.

Reference:
Article; Chehardoli, Gholamabbas; Zolfigol, Mohammad Ali; Derakhshanpanah, Fateme; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 9; (2013); p. 1730 – 1733;,
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100-86-7 , The common heterocyclic compound, 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a cooled (0 C) solution (7.5 mL) of sulfuric acid H2SO4 (95 %), 2mL of trichloroacetonitrile in 28 mL of hexane was added dropwise and under magnetic stirring. Then, (1.5 g, 9.98 mmol) of tertiary alcohol 1 (commercial product) in 15 mL of hexane was added to the solution. After a return to room temperature, the resulting mixture was stirred under reflux for 2.5 h. Then, the solution was cooled at room temperature and versed on ice-cold water (50 mL) under magnetic stirring. The solution is alkalized with ammonia. The organic layer was extracted with dichloromethane (100mL), washed with a saturated aqueous NaCl solution, dried over sodium sulfate, and filtered. The solvent was removed in vacuo and the crude material was then purified by chromatography (silica gel, eluent dichloromethane/methanol 95:5) to afford the imine 6 as pure compound. Yield: 90%. Mp: 74 C. 1H NMR (CDCl3, 300 MHz): delta(ppm) 1.27 (s, 6H, 2-CH3), 2.74 (s, 2H, CH2), 7.22 (d, J=8.7 Hz, 1H), 7.30(m, 1H), 7.38 (m, 1H), 8.11 (d, J=7.8 Hz, 1H). 13C NMR (CDCl3, 75 MHz): delta 26.75 (2C), 39.02, 55.74, 97.67, 122.79, 126.16, 127.60, 128.70, 131.20, 138.31, 157.90. IR (KBr): upsilon 2970 cm -1 (CH3), 1690 cm -1 (C=N), 1618 cm -1 (Ar). HRMS-ES [M+Na]+ calc. for C12H12NCl3 Na 297.9933; found 297.9929.

The synthetic route of 100-86-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aydi, Rihab; Kammoun, Majed; Synthetic Communications; vol. 46; 2; (2016); p. 134 – 144;,
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