Category: 100-83-4

In 2019,Bioorganic & Medicinal Chemistry Letters included an article by Thanh, Nguyen Dinh; Hai, Do Son; Ha, Nguyen Thi Thu; Tung, Do Tien; Le, Cao Thi; Van, Hoang Thi Kim; Toan, Vu Ngoc; Toan, Duong Ngoc; Dang, Le Hai. Synthetic Route of C7H6O2. The article was titled 《Synthesis, biological evaluation and molecular docking study of 1,2,3-1H-triazoles having 4H-pyrano[2,3-d]pyrimidine as potential Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors》. The information in the text is summarized as follows:

Some heterocycles, namely 2-amino-4H-pyran-3-carbonitriles, were synthesized in a three-component reaction from substituted benzaldehydes, malononitrile, and Et acetoacetate. These heterocycles have been converted subsequently into 4H-pyrano[2,3-d]pyrimidine ring by ring-closing reaction with acetic anhydride in the presence of the concentrated sulfuric acid as catalyst. The successive alkylation reaction of lactam N-H bond on pyrimidine-4-one ring was carried out using propargylic bromide in dry acetone in the presence of anhydrous potassium carbonate. The click chem. of 3-propargyl-4H-pyrano[2,3-d]pyrimidine compounds has been accomplished by reaction with tetra-O-acetyl-α-D-glucopyranosyl azide using the metal-organic framework Cu@MOF-5 as a catalyst in absolute ethanol. All the synthesized 1H-1,2,3-triazoles were screened for their in vitro Mycobacterium tuberculosis protein tyrosine phosphatase B (MtbPtpB) inhibition. Kinetic studies of the most active compounds I (R = 3,5-diOMe-4-OH, 3-OH-4-OEt, 3-OMe-4-OH-5-NO2) showed their competitive inhibition toward the MtbPtpB enzyme. The detailed structure-activity relationship (SAR) in vitro and in silico studies suggested that the interaction of Arg63 amino acids with anion type of para-hydroxyl group via a salt bridge of iminium cation was essential for strong inhibitory activity against MtbPtpB.3-Hydroxybenzaldehyde(cas: 100-83-4Synthetic Route of C7H6O2) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Synthetic Route of C7H6O2

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《Green protocol for synthesis of MgFe2O4 nanoparticles and study of their activity as an efficient catalyst for the synthesis of chromene and pyran derivatives under ultrasound irradiation》 was written by Eshtehardian, Bahar; Rouhani, Morteza; Mirjafary, Zohreh. Application In Synthesis of 3-Hydroxybenzaldehyde And the article was included in Journal of the Iranian Chemical Society in 2020. The article conveys some information:

In this study, the MgFe2O4 nanoparticles were synthesized via a green and simple approach. Then an effective procedure to synthesize 2-amino-7-hydroxy-4H-chromene derivatives I (R = H, 2-MeC6H4, 2-FC6H4, etc.) and tetrahydrobenzo[b]pyran derivatives II (R1 = H, 2-ClC6H4, 3-MeOC6H4, etc.) was established through the chem. reaction between different aldehydes, malononitrile and resorcinol (or dimedone) in the presence of MgFe2O4 nanoparticles as a beneficial catalyst in ethanol as solvent under ultrasound irradiation Moreover, the synthesized MgFe2O4 nanoparticles were easily recovered by an external magnet and reused for four times without significant loss of their catalytic activity. Simple, fast, effective and eco-friendly as well as quick purification method along with high product yields are some of the advantages of the present chem. reaction. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
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《An improved protocol for the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones through L-valine-mediated domino three-component strategy》 was written by Kour, Parteek; Ahuja, Monika; Sharma, Pratibha; Kumar, Ashok; Kumar, Anil. Application In Synthesis of 3-Hydroxybenzaldehyde And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2020. The article conveys some information:

An expeditious, metal-free protocol was demonstrated for the synthesis of 3,4-disubstituted isoxazol-5(4H)-one derivatives I [R = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] via L-valine promoted domino three-component cyclocondensation reaction of alkyl acetoacetates, hydroxylamine hydrochloride and benzaldehydes in ethanol under reflux conditions. The reaction proceeded to deliver the desired products I in good to excellent yields (74-97%), exhibited good functional group tolerance and completed in less than 4 min with most of the substrates. Environmentally benign, high yields, short reaction time, non corrosive organocatalyst, mild reaction conditions, clean reaction profiles and the absence of any tedious workup or purification were the beneficial features of this process. Moreover, quantum computational study was performed at B3LYP/6-311G++(d, p) level to investigate the various DFT based mol. descriptors, HOMO-LUMO energy gap and electrostatic potential surface properties of compound I [R = Ph]. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

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In 2019,Journal of Physics: Conference Series included an article by Aderohunmu, Damilola V.; Ajani, Olayinka O.; Oduselu, Gbolahan O.; Adebiyi, Ezekiel F.. Reference of 3-Hydroxybenzaldehyde. The article was titled 《Microwave-assisted synthesis of coumarin-based 5,6-dihydro pyrimidin-2(1H)-one derivatives》. The information in the text is summarized as follows:

Microwave assisted synthesis of novel coumarin-based 5,6-dihydropyrimidin-2(1H)-one derivatives was achieved via a three-step synthetic approach. The reaction was initiated with catalyst supported multicomponent reaction to produce 3-acetylcoumarin which upon condensation with five aromatic aldehydes furnished chalcones. Microwave assisted reaction of chalcones with lone pair donor and urea led to the formation of the targeted coumarin-based 5,6- dihydropyrimidin-2(1H)-ones in good-to-excellent yields. The structures were established using spectroscopic data and notable phys. properties and the results obtained were consistent with the expected structure of the products. The compounds were good for further study to authenticate their applications in drug design and material science research. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Reference of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Reference of 3-Hydroxybenzaldehyde

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The author of 《Facile and efficient protocols for C-C and C-N bond formation reactions using a superparamagnetic palladium complex as reusable catalyst》 were Karimi Zarchi, Mohammad Ali; Darbandizadeh Mohammad Abadi, Seyed Shahab Addin. And the article was published in Research on Chemical Intermediates in 2019. Application In Synthesis of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Facile and efficient protocols for some multicomponent coupling reactions such as the Suzuki reaction and synthesis of polyhydroquinoline and 2,3-dihydroquinazoline-4-(1H)-one derivatives using a superparamagnetic palladium complex as catalyst was developed. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde

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Alcohol – Wikipedia,
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《Introduction of a novel dicationic Bronsted acidic ionic liquid based on pyrazine and its application in the synthesis of xanthenediones and 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions》 was written by Sadati Sorkhi, Seyyed Erfan; Hashemi, Mohammad M.; Ezabadi, Ali. Category: alcohols-buliding-blocksThis research focused onxanthenedione preparation green chem; dimethyl cyclohexanedione aryl aldehyde cyclocondensation ionic liquid catalyst; pyrimidinone preparation green chem; aryl aldehyde ethyl acetoacetate urea cyclocondensation ionic liquid catalyst; pyrazine acidic ionic liquid preparation. The article conveys some information:

A novel dicationic Bronsted acidic ionic liquid based on pyrazine I has been prepared and characterized by FTIR, 1H NMR, 13C NMR, MS, thermal gravimetric and differential thermal gravimetric anal. and also Hammett acidity function. The prepared dicationic ionic liquid I is found to be an efficient and reusable catalyst for the synthesis of xanthenediones II (Ar = Ph, 2-bromophenyl, thiophen-2-yl, etc.) and 3,4-dihydropyrimidin-2(1H)-ones III (Ar1 = 3-chlorophenyl, thiophen-2-yl, 4-fluorophenyl, etc.) under solvent-free conditions. The merits of the developed procedure include novelty in terms of the ionic liquid, easy preparation of the ionic liquid, I easy workup, reusability of the catalyst, high yield, short reaction time and absence of toxic organic solvent.3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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The author of 《Synthesis and characterization of spinel FeAl2O4 (hercynite) magnetic nanoparticles and their application in multicomponent reactions》 were Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Shiri, Lotfi; Taherinia, Zahra. And the article was published in Research on Chemical Intermediates in 2019. Application of 100-83-4 The author mentioned the following in the article:

The spinel ferrite FeAl2O4 (hercynite) MNPs (magnetic nanoparticles) were applied as a reusable catalytic system for the one-pot synthesis of benzo[a]pyrano[2,3-c] phenazine and polyhydroquinoline derivatives via a multicomponent reaction under green reaction conditions. The structure of the prepared nanocatalyst has been characterized by XRD, FTIR, SEM, EDS, BET, and VSM techniques. The FeAl2O4 MNPs act as Lewis acids and offer several advantages such as high yields of products, short reaction times, and easy workup procedure. Moreover, the recycled nanocatalyst was used at least four times without significant loss of its activity. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application of 100-83-4

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In 2019,International Journal of Biological Macromolecules included an article by Valiey, Ehsan; Dekamin, Mohammad G.; Alirezvani, Zahra. Name: 3-Hydroxybenzaldehyde. The article was titled 《Melamine-modified chitosan materials: An efficient and recyclable bifunctional organocatalyst for green synthesis of densely functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives》. The information in the text is summarized as follows:

An environmentally benign protocol for diversity-oriented synthesis of functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been investigated by the reaction of aryl aldehydes, Et acetoacetate, hydrazine derivatives, malononitrile and 4-hydroxycoumarin in the presence of melamine-modified chitosan (Cs-Pr-Me) materials as a reusable bifunctional organocatalyst. The Cs-Pr-Me materials were properly characterized by the Fourier transform IR (FTIR) spectroscopy, CHN elemental anal., thermal gravimetric (TGA) and derivative thermogravimetric (DTG) anal., field emission SEM (FESEM) and energy-dispersive X-ray (EDX) spectroscopy. The remarkable advantages of this green protocol are high to quant. yields of the desired products, short reaction times, wide scope, simple work-up procedure and low loading of a transition metal-free catalyst. An addnl. advantage of this bio-based organocatalyst is the ability to sep. and recycle it easily from the reaction mixture with minimal effort in subsequent runs without significant loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

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The author of 《Synthesis and identification of 1,3-oxazepine derivatives by reaction of Schiff bases with anhydride derivative of cycloheptatriene》 were Mohammad, Ham J.; Alsamarrai, Abdulmajeed S. H.; Mahmood, Rabeah T.. And the article was published in Journal of Pharmaceutical Sciences and Research in 2019. Recommanded Product: 3-Hydroxybenzaldehyde The author mentioned the following in the article:

In this work, 1,3-oxazepine derivatives I [R = H, OH, Cl, Br; R’ = H] and I [R = H, R’ = OH; R = OH, R’ = OMe] were synthesized from reaction of Schiff bases with anhydride derivative of cycloheptatriene. Schiff bases C6H5N=C(4-R,3-R’C6H3) were prepared by the reaction of aniline with benzaldehydes at room temperature Anhydride derivative of cycloheptatriene also prepared from reaction of maleic anhydride with cycloheptatriene without using any solvent. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Recommanded Product: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Nidhi; Pandey, Jaya published their research in Current Research in Green and Sustainable Chemistry in 2021. The article was titled 《DABCO catalyzed, green and efficient, one-pot multicomponent synthesis of 5-aminopyrazole-4-carbonitrile》.Name: 3-Hydroxybenzaldehyde The article contains the following contents:

This work describes an unaccustomed DABCO catalyzed synthetic approach for the synthesis of 5-Aminopyrazole-4-carbonitriles I [R1 = H, 3-OH, 4-OH, 4-Br, 4-Cl, 4-OMe; R2 = H, 3,5-(NO2)2]. A series of substituted derivatives of 5-Aminopyrazole-4-carbonitrile I was synthesized deploying this facile and efficient catalyst in green aqueous media. The reaction involves condensation of malononitrile, benzaldehydes R1C6H4CHO and phenylhydrazines such as phenylhydrazine and 3,5-dinitrophenylhydrazine, generating one-pot pyrazole products. The mechanistic chem. of synthesis encompasses Knoevenagel condensation followed by amination and superseded by intra-mol. cyclization. The synthetic route is a lucid and effective route involving green solvent and less hazardous reaction conditions. Besides this, min. reaction period, easy work-up and elimination of byproducts during synthesis, make this reaction a model reaction for pyrazole synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts