Category: 100-83-4

《Curcumin mono-carbonyl analogs as potent antibacterial compounds: synthesis, biological evaluation and docking simulation study》 was written by Wijianto, B.; Ritmaleni; Purnomo, H.; Nurrochmad, A.. Category: alcohols-buliding-blocks And the article was included in Rasayan Journal of Chemistry in 2020. The article conveys some information:

The present study aims to synthesize, evaluate biol. activity, and study docking of new analog compounds I (R = H; R1 = H, Cl; R2 = H, OH, Br; R3 = H, OH; R4 = H, Br; R5 = H, F; R6 = H; RR6 = -(CH2)3-, -(CH2)2-) as antibacterial. Claisen-Schmidt method used to synthesize compds I. The new analog compounds I have antibacterial activity with IC50 values of 37.1μM, 140μM, resp.; 79μM and 117μM in the aureus; 56.6μM, 282μM, 97.6μM and 186.1μM in subtilis; 291.2μM, 1025.9μM, 679.81μM and 561.9μM in E.coli; 29.5μM, 310.5μM, 32.9μM and 130.6μM in P. aeruginosa; 66.6μM, 328.6μM, 49.3μM and 253.8μM in mutans; 97.2μM, 392.2μM, 129.6μM, and 191.6μM in faecalis; 44,811μM (A113) in C.albicans. Synthesized mono-carbonyl curcumin analog compounds I have antibacterial activity through inhibition of bacterial cell wall synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 3-HydroxybenzaldehydeIn 2022 ,《Design, Synthesis, and Biological Screening for Cytotoxic Activity of Monastrol Analogues》 was published in Polycyclic Aromatic Compounds. The article was written by Asham, Hila; Bohlooli, Shahab; Dostkamel, Donya; Rezvanpoor, Sadaf; Sepehri, Saghi. The article contains the following contents:

A series of 1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives I (Ar = 3-HOC6H4, 4-O2NC6H4, 4-BrC6H5; X = O, S; R = CH3, C2H5) was synthesized through one-pot condensation reaction. Then, they were investigated for in vitro cytotoxic activity. These derivatives showed a good cytotoxic activity against three human cancer cell lines counting MCF-7, HepG-2, and AGS. Among these derivatives, mols. I (Ar = 4-BrC6H5; X = S; R = C2H5) and I (Ar = 3-HOC6H5; X = S; R = CH3) exhibited the highest activity against all cell lines. In vitro cytotoxicity evaluation on all mols. showed that sulfur atom at C2 position, length chain of ester moiety and different substituents on Ph ring positions of tetrahydropyrimidine influenced the antiproliferative activity. Furthermore, according to docking studies a good correlation between exptl. activity and binding affinity was observed In silico studies of mols. showed the participation of hydrophobic interactions and hydrogen bonds with allosteric site Eg5 active site similar to monastrol, Eg5 inhibitor, and co-crystal ligand. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4Quality Control of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Quality Control of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Erbium anchored iminodiacetic acid (IDA) functionalized CoFe2O4 nano particles: an efficient magnetically isolable nanocomposite for the facile synthesis of 1,8-naphthyridines》 was written by Tamoradi, Taiebeh; Daraie, Mansoureh; Heravi, Majid M.; Karmakar, Bikash. Formula: C7H6O2 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

A novel functional material was developed by immobilizing an iminodiacetic acid-erbium (Er) complex onto the surface of magnetic spinel CoFe2O4 nanoparticles. The obtained nanocomposite was fully characterized using different anal. techniques such as FT-IR, XRD, SEM, BET, EDX and X-ray at. mapping anal. The catalytic activity of this novel material was investigated in the successful synthesis of 1,8-naphthyridine derivatives via a three component reaction involving 2-aminopyridine, malononitrile and various aryl aldehydes. The reactions ended up with excellent yields in short reaction times. The catalyst was reused seven times in the proposed reaction without appreciable loss of activity. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Formula: C7H6O2

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The author of 《Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones》 were Taha, Muhammad; Alkadi, Khaled A. A.; Ismail, Nor Hadiani; Imran, Syahrul; Adam, Aishah; Kashif, Syed Muhammad; Shah, Syed Adnan Ali; Jamil, Waqas; Sidiqqui, Salman; Khan, Khalid Mohammed. And the article was published in Arabian Journal of Chemistry in 2019. SDS of cas: 100-83-4 The author mentioned the following in the article:

A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones I [R1 = C5H4N, 4-FC6H4, 2,4-(HO)2C6H3, etc.] was synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involved a 3-step reaction in which a pyridine diamine was converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target mols. after treating them with the appropriate benzohydrazone derivatives The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound I [R1 = 2,4,6-(HO)3C6H2] (140.16 ± 0.36μM) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Desai, Nisheeth C.; Jadeja, Krunalsinh A.; Jadeja, Dharmpalsinh J.; Khedkar, Vijay M.; Jha, Prakash C. published their research in Synthetic Communications in 2021. The article was titled 《Design, synthesis, antimicrobial evaluation, and molecular docking study of some 4-thiazolidinone derivatives containing pyridine and quinazoline moiety》.Application In Synthesis of 3-Hydroxybenzaldehyde The article contains the following contents:

A series of 5-aryl-3-(4-oxo-2-phenylquinazolin-3(4H)-yl)-2-(pyridin-4-yl)thiazolidin-4-ones I (R = H, 3-Me, 4-F, etc.) were synthesized and evaluated for their antibacterial and antifungal activities. The title compounds showed good to excellent inhibition potency for resp. Gram-pos. bacterial strains and Gram-neg. bacterial strains. These compounds exhibited a broad spectrum of inhibitory activity. Mol. docking studies against microbial DNA gyrase sub unit B could provide valuable insights into the binding affinity of these mols. and their plausible mechanism of antimicrobial action. Most of the compounds exhibited excellent activity against bacterial and fungal strains resp. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Piaopiao; Peng, Yayuan; Xu, Xuan; Wang, Zhiyuan; Wu, Zengrui; Li, Weihua; Tang, Yun; Liu, Guixia published an article in 2021. The article was titled 《In silico prediction of mitochondrial toxicity of chemicals using machine learning methods》, and you may find the article in Journal of Applied Toxicology.HPLC of Formula: 100-83-4 The information in the text is summarized as follows:

Mitochondria are important organelles in human cells, providing more than 95% of the energy. However, some drugs and environmental chems. could induce mitochondrial dysfunction, which might cause complex diseases and even worsen the condition of patients with mitochondrial damage. Some drugs have been withdrawn from the market due to their severe mitochondrial toxicity, such as troglitazone. Therefore, there is an urgent need to develop models that could accurately predict the mitochondrial toxicity of chems. In this paper, suitable data were obtained from literature and databases first. Then nine types of fingerprints were used to characterize these compounds Finally, different algorithms were used to build models. Meanwhile, the applicability domain of the prediction models was defined. We have also explored the structural alerts of mitochondrial toxicity, which would be helpful for medicinal chemists to better predict mitochondrial toxicity and further optimize lead compounds The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4HPLC of Formula: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.HPLC of Formula: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

HPLC of Formula: 100-83-4In 2019 ,《Ultrasound mediated green synthesis of pyrano[2,3-c]pyrazoles by using Mn doped ZrO2》 appeared in Arabian Journal of Chemistry. The author of the article were Maddila, Suresh; Gorle, Sridevi; Shabalala, Sebenzile; Oyetade, Oluwaseun; Maddila, Surya Narayana; Lavanya, Palakondu; Jonnalagadda, Sreekantha B.. The article conveys some information:

Mn doped zirconia is utilized as an environment-friendly and efficient catalyst for an ultrasound mediated four-component coupling reaction, containing dimethylacetylenedicarboxylate/ethyl acetoacetate, hydrazine hydrate, malononitrile, and aromatic aldehyde RC6H4CHO [R = 2-F, 4-Br, 3-OH, 2-OCH3, 2,3-(OCH3)2, 2,5-(OCH3)2, 2,4,6-(OCH3)3]. These reactions were performed under green solvent conditions, to yield pyrano[2,3-c]pyrazole-3-carboxylate derivatives I [R1 = C(O)OCH3] and pyrano[2,3-c]pyrazole-5-carbonitrile derivatives I (R1 = CH3) with good to excellent yields (88-98%). The main benefits of this process are short reaction times, easy work-up, reusability of the catalyst and no chromatog. purifications. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4HPLC of Formula: 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.HPLC of Formula: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Current Organocatalysis included an article by Mosallanezhad, Asiyeh; Kiyani, Hamzeh. SDS of cas: 100-83-4. The article was titled 《Green Synthesis of 3-Substituted-4-arylmethylideneisoxazol-5(4H)-one Derivatives Catalyzed by Salicylic Acid》. The information in the text is summarized as follows:

The efficient and environmental friendliness procedure for the synthesis of isoxazol-5(4H)-ones was introduced. Salicylic acid was used as an inexpensive, easy to handle and safe catalyst for the synthesis of title compounds 3-Substituted-4-arylmethylideneisoxazol-5(4H)-ones were obtained from readily available aryl/heteroaryl aldehydes and β-keto esters via the cyclocondensation reaction without using thermal, microwave or ultrasound conditions. It must be highlighted that the procedure is operationally mild and simple, and the desired small heterocycles were obtained in good to high yields.3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4) was used in this study.

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.SDS of cas: 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Ultrasonics Sonochemistry included an article by Taheri-Ledari, Reza; Rahimi, Jamal; Maleki, Ali. COA of Formula: C7H6O2. The article was titled 《Synergistic catalytic effect between ultrasound waves and pyrimidine-2,4-diamine-functionalized magnetic nanoparticles: Applied for synthesis of 1,4-dihydropyridine pharmaceutical derivatives》. The information in the text is summarized as follows:

A convenient strategy for synthesis of the various derivatives of 1,4-dihydropyridine (1,4-DHP), as one of the most important pharmaceutical compounds I (R = Ph, 3NO2C6H4, 4ClC6H4, etc.; R1 = Me, Et), II, is presented in this study. For this purpose, firstly, magnetic iron oxide nanoparticles (Fe3O4 NPs) were fabricated and suitably coated by silica network (SiO2) and trimethoxy vinylsilane (TMVS). Then, their surfaces were well functionalized with pyrimidine-2,4-diamine (PDA) as the main active sites for catalyzing the synthesis reactions. In this regard, the performance of three different methods including reflux, microwave (MW) and ultrasound wave (USW) irradiations have been comparatively monitored via studying various analyses on the fabricated nanocatalyst (Fe3O4/SiO2-PDA). Concisely, high efficiency of the USW irradiation (in an ultrasound cleaning bath with a frequency of 50 kHz and power of 250 W/L) has been well proven through the investigation of the main factors such as excellent surface-functionalization, core/shell structure conservation, particle uniformity, close size distribution of the particles, and great inhibition of the particle aggregation. Then, the effectiveness of the USW irradiation as a promising co-catalyst agent has been clearly demonstrated in the 1,4-dihydropyridines I, II synthesis reactions. It has been concluded that the USW could provide more appropriate conditions for activation of the catalytic sites of Fe3O4/SiO2-PDA NPs. However, high reaction yields (89%) have been obtained in the short reaction times (10 min) due to the substantial synergistic effect between the presented nanocatalyst and USW. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4COA of Formula: C7H6O2)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.COA of Formula: C7H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Hybrid 3,4-dihydropyrimidin-2-(thi)ones as dual-functional bioactive molecules: fluorescent probes and cytotoxic agents to cancer cells》 was written by de Souza, Vanessa P.; Santos, Fabiano S.; Rodembusch, Fabiano S.; Braga, Carolyne B.; Ornelas, Catia; Pilli, Ronaldo A.; Russowsky, Dennis. Product Details of 100-83-4 And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

A series of new hybrid fluorescent Biginelli compounds, including a Monastrol derivative, were designed and synthesized with good yields. The photophys. studies revealed dual fluorescence emission, attributed to excited enol forms (E*) and tautomeric (K*) species, resp., due to the ESIPT mechanism. The cytotoxic activity of all compounds was evaluated against MCF-7, Caco-2 and PC3 cancer cell lines and PNT2 normal prostate cells. The fluorescent Monastrol derivative 8f was the most active with cytotoxic activity very similar to cisplatin, whereas derivative 8c was the most selective towards the PC3 prostate cancer cells. The confocal laser scanning microscopy images of PC3 and MCF-7 cancer cell lines were acquired after incubation of the fluorescent Biginelli hybrids 8c and 8f, resp., demonstrating efficient cellular uptake of both compounds and strong fluorescence within the intracellular medium. These results show that the new hybrid 3,4-dihydropyrimidin-2-(thi)ones are dual-function bioactive compounds that act both as fluorescent probes and antineoplastic agents. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4)

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Product Details of 100-83-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts