100-83-4 Archives - Page 3 of 10 - Alcohols-buliding-blocks

Karimi, Fatemeh’s team published research in Molecular Catalysis in 2019 | CAS: 100-83-4

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Application In Synthesis of 3-Hydroxybenzaldehyde

In 2019,Molecular Catalysis included an article by Karimi, Fatemeh; Zolfigol, Mohammad Ali; Yarie, Meysam. Application In Synthesis of 3-Hydroxybenzaldehyde. The article was titled 《A novel and reusable ionically tagged nanomagnetic catalyst: Application for the preparation of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitriles via vinylogous anomeric based oxidation》. The information in the text is summarized as follows:

Herein, Fe3O4@O2PO2(CH2)2NH3+CF3CO-2 as a novel and reusable ionically tagged nanomagnetic catalyst is reported. It was characterized by several techniques including Fourier transform IR (FT-IR) spectroscopy, thermo gravimetric anal./DTA (TGA/DTA), SEM (SEM), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and energy dispersive X-ray (EDX) anal. The catalytic behavior of the Fe3O4@O2PO2(CH2)2NH3+CF3CO-2 was examined for the synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitrile derivatives Exptl. data approved that the final step of the plausible mechanism proceeded via a vinylogous anomeric based oxidation mechanism. Described catalyst showed excellent potential of recycling and reusing for the described multicomponent reaction. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taha, Muhammad’s team published research in Bioorganic Chemistry in 2020 | CAS: 100-83-4

《Synthesis of indole-based acetohydrazide analogs: their in vitro and in silico thymidine phosphorylase studies》 was written by Taha, Muhammad; Aldhamin, Ebaa Ahmed Jassim; Almandil, Noor Barak; Anouar, El Hassane; Uddin, Nizam; Alomari, Munther; Rahim, Fazal; Adalat, Bushra; Ibrahim, Mohamad; Nawaz, Fasial; Iqbal, Naveed; Alghanem, Bandar; Altolayyan, Abdulelah; Khan, Khalid Mohammed. Category: alcohols-buliding-blocks And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this study, a series of indole-based acetohydrazides I [R = 4-HOC6H4, 2-MeOC6H4 2,3-(HO)2C6H3, 2,4-(MeO)2C6H3, etc.] were synthesized and characterized. The products I were tested for their thymidine phosphorylase inhibitory potential. These derivatives inhibited thymidine phosphorylase at different concentration ranging from 1.10 ± 0.10 to 41.10 ± 1.10μM when compared with the standard 7-deazaxanthine (IC50 value 38.68 ± 1.12μM). The compound I [R = 2,4,6-(HO)3C6H2] was found to be the most potent among the series with IC50 1.10 ± 0.10μM. The structure activity relationships have been established for all compounds keeping in the view the role of substitution and the effect of functional group which significantly affect thymidine phosphorylase activity. The nature of binding interactions of the most potent compounds and active sites of the enzymes was confirmed through mol. docking study. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gerlach, T.’s team published research in Chemie Ingenieur Technik in 2020 | CAS: 100-83-4

《Light-induced enzyme deactivation as a new tool to prevent cross reactions in multistep enzyme cascades》 was published in Chemie Ingenieur Technik in 2020. These research results belong to Gerlach, T.; Drepper, T.; Rother, D.. Quality Control of 3-Hydroxybenzaldehyde The article mentions the following:

To eliminate cross reactivity in one-pot reaction systems, enzymes prone to side reactivities are combined with produce reactive oxygen species upon irradiation The enzyme fusions can be added to the corresponding reaction step enabling the catalyst activity to be switched off selectively. Here, an enzyme cascade starting from 3-hydroxy benzaldehyde and pyruvate to a trisubstituted tetrahydroisoquinoline has been chosen as a test system. CA> The first cascade step encompasses a carboligation conducted by the pyruvate decarboxylase variant E469G/W543H from Acetobacter pasteurianus (ApPDC E469G/W54m). Afterwards a reductive amination occurs, mediated by the Chromobacterium violaceum transaminase (Cv2025). This cascade is a suitable target as in a one-pot reaction approach across reactivity occurs. The ApPDC E469G/W543H was genetically linked to a photosensitizer, the singlet oxygen photosensitizing protein (SOPP3). After illumination with blue light (450 nm), the relative activity of SOPP3-ApPDC E469G/W543H could be reducedto 10% (Fig. A). The Cv2025 was inactivated simply by illuminating the cofactor of the transaminase pyridoxal 5-phosphate and could also be inactivated to 10% residual activity (Fig.B). As both inactivation, steps still need 30-120 min to reach the goal, the light-inactivation setups are current target to optimization. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Quality Control of 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aoun, Sameh’s team published research in Synthetic Communications in 2019 | CAS: 100-83-4

The author of 《A novel hydroxy-bisphosphonic acid prodrug as a candidate for the delivery of ibuprofen to bone》 were Aoun, Sameh; Bennour, Haythem. And the article was published in Synthetic Communications in 2019. Recommanded Product: 100-83-4 The author mentioned the following in the article:

Active targeting with controlled delivery of anti-inflammatory drugs to the bone is not sufficiently explored. In this study, concise and novel synthesis of a hydroxy-bisphosphonic acid (HBPA) prodrug containing ibuprofen is described. The key step consisted of preparing the HBPA function from a carboxylic acid precursor, in mild conditions and using appropriate Arbuzov reactions with tris(trimethylsilyl)phosphite. This prodrug would be an excellent candidate for the treatment of bone inflammation diseases such as rheumatoid arthritis. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maleki, A.’s team published research in Materials Today Chemistry in 2019 | CAS: 100-83-4

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.COA of Formula: C7H6O2

COA of Formula: C7H6O2In 2019 ,《Multicomponent synthesis of pyrano[2,3-d]pyrimidine derivatives via a direct one-pot strategy executed by novel designed copperated Fe3O4@polyvinyl alcohol magnetic nanoparticles》 appeared in Materials Today Chemistry. The author of the article were Maleki, A.; Niksefat, M.; Rahimi, J.; Taheri-Ledari, R.. The article conveys some information:

A magnetic nanocatalyst system was designed and used for facilitating one-pot synthesis of pyrano[2,3-d]pyrimidine derivatives I (R = Ph, 2,4-dichlorophenyl, 2-thienyl, etc.). This product takes advantages of copper(II) ions chelated with oxygen atoms of polyvinyl alc. (PVA) strands, which were well composited with iron oxide magnetic nanoparticles during an in situ process. High reaction yields were obtained by using this efficient nanocatalyst in the short times and under mild conditions. High hydrophilicity, convenient separation, and acceptable recyclability have been investigated and introduced as the features of this nanocatalyst. Structural studies related to the nanoscale materials have also been carried out and well interpreted in this report. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4COA of Formula: C7H6O2)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rahimi, J.’s team published research in Materials Today Chemistry in 2020 | CAS: 100-83-4

Electric Literature of C7H6O2In 2020 ,《Preparation of a trihydrazinotriazine-functionalized core-shell nanocatalyst as an extremely efficient catalyst for the synthesis of benzoxanthenes》 was published in Materials Today Chemistry. The article was written by Rahimi, J.; Maleki, A.. The article contains the following contents:

Herein, trihydrazinotriazine (THDT)-coated Fe3O4@SiO2 as a novel amino-functionalized magnetic nanocompostie was introduced. The nanocatalyst was fully characterized and proved the morphol. and magnetic property of the nanoparticles by using essential analyses. The basic attributed of the amino-rich porous surface of the nanocomposite provided a desirable environment for enhancing various reaction conditions. Several benzoxanthenes were synthesized using Fe3O4@SiO2-THDT nanocatalysts, to examine the applicability of the nanocatalyst in organic reactions. The nanocomposite successfully improved the reaction conditions and provided the benzoxanthenes in an environmentally friendly procedure, which afforded product in excellent yields (80-96%) and reduced time. The nanomagnetic catalyst was easily recovered after each trial by using an external magnet. After six successive runs, the loss of catalytic activity of the nanocomposite was negligible. Finally, a plausible mechanism for the preparation of the benzoxanthenes derivatives using the THDT-functionalized core-shell magnetic nanocatalyst was propounded . In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Electric Literature of C7H6O2)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saha, Arijit’s team published research in Current Organocatalysis in 2019 | CAS: 100-83-4

Related Products of 100-83-4In 2019 ,《[AcMIM]FeCl4: A Magnetically Separable Organocatalyst for the Clean Synthesis of Tetrahydrobenzo[b]pyran Derivatives》 was published in Current Organocatalysis. The article was written by Saha, Arijit; Payra, Soumen; Asatkar, Archana; Patel, Ashok Raj; Banerjee, Subhash. The article contains the following contents:

A facile and convenient methodol. has been developed for the synthesis of bio-active tetrahydrobenzo[b]pyran derivatives I (R = H, 3-Cl, 4-NO2, 3,4-(OCH3)2, etc.) using [AcMIm]FeCl4 ionic liquid as an sufficient and reusable magnetically separable oganocatalyst under environment-benign conditions. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdolmohammadi, Shahrzad’s team published research in RSC Advances in 2019 | CAS: 100-83-4

In 2019,RSC Advances included an article by Abdolmohammadi, Shahrzad; Mirza, Behrooz; Vessally, Esmail. Safety of 3-Hydroxybenzaldehyde. The article was titled 《Immobilized TiO2 nanoparticles on carbon nanotubes: an efficient heterogeneous catalyst for the synthesis of chromeno[b]pyridine derivatives under ultrasonic irradiation》. The information in the text is summarized as follows:

A new protocol for the synthesis of chromeno[b]pyridine derivatives was described via a three-component reaction of 4-aminocoumarin, aromatic aldehydes and malononitrile catalyzed by TiO2 nanoparticles immobilized on carbon nanotubes (TiO2-CNTs) as an efficient heterogeneous catalyst under ultrasonic irradiation in water. The sustainable and economic benefits of the protocol were the high yields of products, short reaction time, simple work-up procedure, and use of a non-toxic and reusable catalyst.3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tsolekile, Ncediwe’s team published research in Scientific Reports in 2020 | CAS: 100-83-4

《Cytotoxicity, fluorescence tagging and gene-expression study of CuInS/ZnS QDS – meso (hydroxyphenyl) porphyrin conjugate against human monocytic leukemia cells》 was written by Tsolekile, Ncediwe; Nahle, Sara; Zikalala, Nkosingiphile; Parani, Sundararajan; Sakho, El Hadji Mamour; Joubert, Olivier; Matoetoe, Mangaka C.; Songca, Sandile P.; Oluwafemi, Oluwatobi S.. Name: 3-Hydroxybenzaldehyde And the article was included in Scientific Reports in 2020. The article conveys some information:

The toxicity of heavy metals present in binary semiconductor nanoparticles also known as quantum dots (QDs) has hindered their wide applications hence the advent of non-toxic ternary quantum dots. These new group of quantum dots have been shown to possess some therapeutic action against cancer cell lines but not significant enough to be referred to as an ideal therapeutic agent. In this report, we address this problem by conjugating red emitting CuInS/ZnS QDs to a 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin -photosensitizer for improved bioactivities. The glutathione capped CuInS/ZnS QDs were synthesized in an aqueous medium using a kitchen pressure cooker at different Cu: In ratios (1:4 and 1:8) and at varied temperatures (95°C, 190°C and 235°C). Optical properties show that the as-synthesized CuInS/ZnS QDs become red-shifted compared to the core (CuInS) after passivation with emission in the red region while the cytotoxicity study revealed excellent cell viability against normal kidney fibroblasts (BHK21). The highly fluorescent, water-soluble QDs were conjugated to 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (mTHPP) via esterification reactions at room temperature The resultant water-soluble conjugate was then used for the cytotoxicity, fluorescent imaging and gene expression study against human monocytic leukemia cells (THP-1). Our result showed that the conjugate possessed high cytotoxicity against THP-1 cells with enhanced localized cell uptake compared to the bare QDs. In addition, the gene expression study revealed that the conjugate induced inflammation compared to the QDs as NFKB gene was over-expressed upon cell inflammation while the singlet oxygen (1O2) study showed the conjugate possessed large amount of 1O2, three times than the bare porphyrin. Thus, the as-synthesized conjugate looks promising as a therapeutic agent for cancer therapy. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hurtado, Carolina Ramos’s team published research in Nanomaterials in 2021 | CAS: 100-83-4

Hurtado, Carolina Ramos; Hurtado, Gabriela Ramos; Lupeti de Cena, Gabrielle; Queiroz, Rafaela Campos; Silva, Alexandre Vieira; Diniz, Milton Faria; dos Santos, Veronica Ribeiro; Trava-Airoldi, Vladimir; da Silva Baptista, Mauricio; Tsolekile, Ncediwe; Oluwafemi, Oluwatobi Samuel; Conceicao, Katia; Tada, Dayane Batista published their research in Nanomaterials in 2021. The article was titled 《Diamond nanoparticles-porphyrin mTHPP conjugate as photosensitizing platform: cytotoxicity and antibacterial activity》.Computed Properties of C7H6O2 The article contains the following contents:

Conjugation of photosensitizers (PS) with nanoparticles has been largely used as a strategy to stabilize PS in the biol. medium resulting in photosensitizing nanoparticles of enhanced photoactivity. Herein, Meso-5, 10, 15, 20-tetrakis (3-hydroxyphenyl) phorphyryn (mTHPP) was conjugated with diamond nanoparticles (ND) by covalent bond. Nanoconjugate ND-mTHPP showed suitable stability in aqueous suspension with 58 nm of hydrodynamic diameter and Zeta potential of -23 mV. The antibacterial activity of ND-mTHPP was evaluated against Escherichia coli for different incubation times (0-24 h). The optimal activity was observed after 2 h of incubation and irradiation (660 nm; 51 J/cm2) performed right after the addition of ND-mTHPP (100 μg/mL) to the bacterial suspension. The inhibitory activity was 56% whereas ampicillin at the same conditions provided only 14% of bacterial growth inhibition. SEM images showed agglomerate of ND-mTHPP adsorbed on the bacterial cell wall, suggesting that the antimicrobial activity of ND-mTHPP was afforded by inducing membrane damage. Cytotoxicity against murine embryonic fibroblast cells (MEF) was also evaluated and ND-mTHPP was shown to be noncytotoxic since viability of cells cultured for 24 h in the presence of the nanoconjugate (100 μg/mL) was 78%. Considering the enhanced antibacterial activity and the absence of cytotoxic effect, it is possible to consider the ND-mTHPP nanoconjugate as promising platform for application in antimicrobial photodynamic therapy (aPDT). In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts