100-83-4 Archives - Page 2 of 10 - Alcohols-buliding-blocks

Chen, Kuang-Yao’s team published research in Biomolecules in 2022 | CAS: 100-83-4

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

In 2022,Chen, Kuang-Yao; Chen, Yi-Ju; Cheng, Chien-Ju; Jhan, Kai-Yuan; Wang, Lian-Chen published an article in Biomolecules. The title of the article was ãBenzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stressã?Safety of 3-Hydroxybenzaldehyde The author mentioned the following in the article:

Excretory-secretory products (ESPs) are the main research targets for investigating the hosts and helminths interaction. Parasitic worms can migrate to parasitic sites and avoid the host immune response by secreting this product. Angiostrongylus cantonensis is an important food-borne zoonotic parasite that causes severe neuropathol. damage and symptoms, including eosinophilic meningitis or meningoencephalitis in humans. Benzaldehydes are organic compounds composed of a benzene ring and formyl substituents. This compound has anti-inflammatory and antioxidation properties. Previous studies showed that 3-hydroxybenzaldehyde (3-HBA) and 4-hydroxybenzaldehyde (4-HBA) can reduce apoptosis in A. cantonensis ESP-treated astrocytes. These results on the protective effect underlying benzaldehyde have primarily focused on cell survival. The study was designed to investigate the mol. mechanisms of endoplasmic reticulum stress (ER stress) and oxidative stress in astrocytes in A. cantonensis ESP-treated astrocytes and to evaluate the therapeutic consequent of 3-HBA and 4-HBA. First, we initially established the RNA-seq dataset in each group, including normal, ESPs, ESPs + 3-HBA, and ESPs + 4-HBA. We also found that benzaldehyde (3-HBA and 4-HBA) can stimulate astrocytes to express ER stress-related mols. after ESP treatment. The level of oxidative stress could also be decreased in astrocytes by elevating antioxidant activity and reducing ROS generation. These results suggested that benzaldehyde may be a potential therapeutic compound for human angiostrongyliasis to support brain cell survival by inducing the expression levels of ER stress- and oxidative stress-related pathways. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde)

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Yang, Yao’s team published research in Molecular Catalysis in 2020 | CAS: 100-83-4

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Formula: C7H6O2

ãStructure-induced Lewis-base Ga4B2O9 and its superior performance in Knoevenagel condensation reactionã?was written by Yang, Yao; Wang, Duo; Jiang, Pengfei; Gao, Wenliang; Cong, Rihong; Yang, Tao. Formula: C7H6O2 And the article was included in Molecular Catalysis in 2020. The article conveys some information:

Solid Lewis-base catalysis is important in the production of fine chems. A Lewis-base Ga4B2O9 was synthesized by high temperature solid state reactions. It exhibited a high yield (90%) and a high stability in Knoevenagel condensation reactions, where several aldehydes were combined with malononitrile to form Î±,Î²-unsaturated compounds through nucleophilic addition reactions. Reaction kinetics analyses indicated Knoevenagel condensation reactions over Ga4B2O9 catalyst obeyed a second-order characteristics and the calculated activation energy was â?1.6 kJ/mol, suggesting that Langmuir-Hinshelwood absorption pathway was probably employed. The structural evolution from Ga4B2O9âGaBO3âÎ?Ga2O3 evidenced that the structure-induced basicity of Ga4B2O9 attributed to the special Î¼3-O atoms linked exclusively to 3 five-coordinated Ga3+. This investigation proves a convincing structure-property correlation in Ga-based solid base materials and helps developing an alternative avenue towards the design of new intrinsic solid base catalysts. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

Referemce:
Alcohol – Wikipedia,
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Milovanovic, Jelena’s team published research in Catalysts in 2021 | CAS: 100-83-4

Milovanovic, Jelena; Gunduz, Miyase Gozde; Zerva, Anastasia; Petkovic, Milos; Beskoski, Vladimir; Thomaidis, Nikolaos S.; Topakas, Evangelos; Nikodinovic-Runic, Jasmina published their research in Catalysts in 2021. The article was titled ãSynthesis and laccase-mediated oxidation of new condensed 1,4-dihydropyridine derivativesã?SDS of cas: 100-83-4 The article contains the following contents:

Herein the synthesis and laccase mediated oxidation of six novel 1,4-dihydropyridine-based hexahydroquinolines I [R1 = OH, R2 = H; R1 = R2 = OH; R1 = NO2, R2 = OH] and decahydroacridines II was described. Different laccase enzymes was employed with varying redox potential to convert I and II to the corresponding pyridine-containing tetrahydroquinoline and octahydroacridine derivatives, resp. Intensively colored products were detected in all biocatalytic reactions using laccase from Trametes versicolor (TvLacc), possibly due to the presence of conjugated chromophores formed in products after oxidation The NMR assessment confirmed that the oxidation product of I [R1 = OH, R2 = H] was its corresponding pyridine-bearing tetrahydroquinoline derivative Laccase from Bacillus subtillis was the most efficient enzyme for this group of substrates using HPLC assessment. Overall, it could be concluded that I [R1 = R2 = OH] and II [R1 = R2 = OH], bearing catecholic structures, were easily oxidized by all tested laccases, while I [R1 = NO2, R2 = OH] and II [R1 = NO2, R2 = OH] containing electron-withdrawing nitro-groups are not readily oxidized by laccases. Compound I [R1 = OH, R2 = H] with decahydroacridine moiety consisting of three condensed six-membered rings that contribute not only to the volume but also to the higher redox potential of the substrate rendered this compound not to be biotransformed with any of the mentioned enzymes. Overall, we showed that multiple anal. approaches were needed in order to assess biocatalytical reactions. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

Referemce:
Alcohol – Wikipedia,
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Nguyen, Thanh Thi’s team published research in RSC Advances in 2019 | CAS: 100-83-4

The author of ãAn efficient multicomponent synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles catalyzed by a magnetic nanoparticle supported Lewis acidic deep eutectic solventã?were Nguyen, Thanh Thi; Thi Le, Ngoc-Phuong; Nguyen, The Thai; Tran, Phuong Hoang. And the article was published in RSC Advances in 2019. Computed Properties of C7H6O2 The author mentioned the following in the article:

A mild and highly efficient reaction for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles I (R = 2-hydroxyphenyl, 2-fluorophenyl, 1H-indol-3-yl, etc.; R1 = H, phenyl) catalyzed by a magnetically supported Lewis acidic deep eutectic solvent on magnetic nanoparticles (LADES@MNP) has been developed via one-pot multicomponent processes under solvent-free sonication. These reactions have good to excellent yields, mild conditions, and work-up simplicity. This method represents a new method for the preparation of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles I. More importantly, LADES@MNP can be easily recovered by magnetic separation and reused five times without significant loss of catalytic activity. In the experiment, the researchers used 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

Referemce:
Alcohol – Wikipedia,
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Khalifeh, Reza’s team published research in Catalysis Letters in 2019 | CAS: 100-83-4

In 2019,Catalysis Letters included an article by Khalifeh, Reza; Shahimoridi, Roghayeh; Rajabzadeh, Maryam. Name: 3-Hydroxybenzaldehyde. The article was titled ãDesign and Synthesis of Novel Cage like CuFe2O4 Hollow Nanostructure as an Efficient Catalyst for Synthesis of 4,4′-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)sã? The information in the text is summarized as follows:

Cage like CuFe2O4 hollow nanostructure has been synthesized successfully using hard template method under the hydrothermal condition. Cu(NO3)2·6H2O, Fe(NO3)2·9H2O and glucose were dissolved in water, and the mixture was heated to 180 °C in an autoclave. The removal of carbon was achieved by calcination at 800 °C and finally, the cage like CuFe2O4 hollow structure was obtained. This cage like CuFe2O4 hollow structure was characterized by FE-SEM, EDS, TEM and XRD. The catalytic performance of this hollow nanostructure was evaluated for the synthesis of bis pyrazol-5-ols. To this end, the one pot condensation reactions of phenylhydrazine, Et acetoacetate and different aromatic aldehyde at 80 °C under the solvent free condition were performed. The optimum amount of applied catalyst for this transformation was obtained to be 0.04 mol %. Noteworthy, catalyst was easily recoverable and was reused for 7 times with the remaining of its initial structure as well as its catalytic activity. Cage like CuFe2O4 hollow nanostructure are stably and efficiently attainable for conversion of precursors to 4,4′-(aryl methylene)bis(3-methyl-1H-pyrazol-5-ol)s. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
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Hajjami, Maryam’s team published research in Catalysis Letters in 2019 | CAS: 100-83-4

In 2019,Catalysis Letters included an article by Hajjami, Maryam; Gholamian, Fatemeh; Hudson, Robert H. E.; Sanati, Ali Mohammad. Recommanded Product: 3-Hydroxybenzaldehyde. The article was titled 《FSM-16/AEPC-SO3H: Synthesis, Characterization and Its Application for the Catalytic Preparation of 1,8-Dioxo-octahydroxanthene and Tetrahydrobenzo[b]pyran Derivatives》. The information in the text is summarized as follows:

A new acidic mesoporous catalyst (FSM-16/AEPC-SO3H) was successfully synthesized and characterized by FT-IR, TGA, XRD, SEM, TEM, EDS and BET techniques. The FSM-16/AEPC-SO3H showed excellent catalytic activity for the synthesis of 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives The synthesized catalyst can also be recycled. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

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Alcohol – Wikipedia,
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Rahim, Fazal’s team published research in Bioorganic Chemistry in 2020 | CAS: 100-83-4

《Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study》 was published in Bioorganic Chemistry in 2020. These research results belong to Rahim, Fazal; Zaman, Khalid; Taha, Muhammad; Ullah, Hayat; Ghufran, Mehreen; Wadood, Abdul; Rehman, Wajid; Uddin, Nizam; Shah, Syed Adnan Ali; Sajid, Muhammad; Nawaz, Faisal; Khan, Khalid Mohammed. SDS of cas: 100-83-4 The article mentions the following:

Synthesis and biol. screening of benzimidazole-bearing bis-Schiff bases I (R1 = 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, 4-BrC6H4; R2 = 3-HOC6H4, 2-O2NC6H4, 2,4-Cl2C6H3, etc.) for their α-glucosidase inhibitory activity are described. All compounds I exhibited excellent to good inhibitory potential (IC50 = 2.20 ± 0.1 to 88.60 ± 1.70μM) when compared with standard drug acarbose (IC50 = 38.45 ± 0.80μM). A structure activity relationship has been established on the basis of electronic effects and position of different substituents present on Ph ring. In order to rationalize the binding interactions of most active analogs with the active site of α-glucosidase enzyme, mol. docking study was conducted. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxybenzaldehyde(cas: 100-83-4SDS of cas: 100-83-4)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ade, Alberta’s team published research in Journal of Chemistry in 2020 | CAS: 100-83-4

《Synthesis and antimicrobial resistant modulatory activity of 2,4-dinitrophenylhydrazone derivatives as agents against some ESKAPE human pathogens》 was published in Journal of Chemistry in 2020. These research results belong to Ade, Alberta; Amengor, Cedric D. K.; Brobbey, Abena; Ayensu, Isaac; Harley, Benjamin K.; Boakye, Yaw Duah. Application of 100-83-4 The article mentions the following:

A library of six novel phenylhydrazones 2,4-di-NO2C6H3NHN=CR(R1) [R = H, Ph; R1 = H, 2-OH, 3-OH, 2,4-di-OH, 3-MeO-4OH] were synthesized and evaluated for their in vitro antimicrobial and resistance modulating activity against a panel of Gram-pos., Gram-neg., and fungal species. The compounds were produced in good yields of 60-92% weight/weight and characterized using m.p., UV-visible spectroscopy, IR, and NMR (1H, 13C, and DEPT-Q) techniques. Mass spectroscopy was used to confirm the identity of one of the most active compounds, 2,4-di-NO2C6H3NHN=CR(R1) [R = H, R1 = 2-OH]. The phenylhydrazones showed activity against all the six selected microorganisms with min. inhibitory concentration (MIC) values of the most active compounds, 2,4-di-NO2C6H3NHN=CR(R1) [R = Ph, R1 = H; R = H, R1 = 2-OH], at 138μM (Klebsiella pneumoniae) and 165μM (Streptococcus pneumoniae), resp. Compound 2,4-di-NO2C6H3NHN=CR(R1) [R = Ph, R1 = H] further demonstrated a high resistance modulatory activity at 1.078μM against Streptococcus pneumoniae and Klebsiella pneumoniae. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Application of 100-83-4)

Referemce:
Alcohol – Wikipedia,
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Sagha, Mohsen’s team published research in Molecular Diversity in 2022 | CAS: 100-83-4

Sagha, Mohsen; Mousaei, Fatemeh; Salahi, Mahtab; Razzaghi-Asl, Nima published an article in 2022. The article was titled 《Synthesis of new 2-aminothiazolyl/benzothiazolyl-based 3,4-dihydropyrimidinones and evaluation of their effects on adenocarcinoma gastric cell migration》, and you may find the article in Molecular Diversity.Safety of 3-Hydroxybenzaldehyde The information in the text is summarized as follows:

A number of new 2-aminothiazolyl/benzothiazolyl derivatives of 3,4-dihydropyrimidinones I [R = 4-FC6H4, 4-ClC6H4, 4-O2NC6H4] and II [R1 = Ph, 3-HOC6H4, 3-BrC6H4] were synthesized and structurally identified, and then their effects on the migration behavior of human AGS cells (gastric cancer cells) were investigated. Mol. docking and mol. dynamics (MD) simulations were applied to explore binding potential and realistic binding model of the assessed derivatives through identification of key amino acid residues within L5/α2/α3 allosteric site of kinesin 5 (Eg5) as a validated microtubule-dependent target for monastrol as a privileged DHPM derivative In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

Referemce:
Alcohol – Wikipedia,
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Chen, Kuang-Yao’s team published research in Biomedical Journal in 2021 | CAS: 100-83-4

《3-Hydroxybenzaldehyde and 4-Hydroxybenzaldehyde enhance survival of mouse astrocytes treated with Angiostrongylus cantonensis young adults excretory/secretory products》 was written by Chen, Kuang-Yao; Chen, Yi-Ju; Cheng, Chien-Ju; Jhan, Kai-Yuan; Chiu, Cheng-Hsun; Wang, Lian-Chen. Electric Literature of C7H6O2 And the article was included in Biomedical Journal in 2021. The article conveys some information:

Human cerebral angiostrongyliasis, induced by Angiostrongylus cantonensis, is an emerging disease in many parts of the world. A. cantonensis is also an important causative agent of eosinophilic meningitis and eosinophilic meningoencephalitis in humans. 3-Hydroxybenzaldehyde (3-HBA) and 4-Hydroxybenzaldehyde (4-HBA) have been shown to increase intracellular antioxidant activity, vasculoprotective potency, wound healing, and cell migration. However, the function of 3-HBA and 4-HBA in mouse astrocytes in response to A. cantonensis young adults excretory-secretory products (ESPs) treatment remains unclear. Here, we examined the effect of 3-HBA and 4-HBA by real-time qPCR, western blotting, and cell viability assay in astrocytes after A. cantonensis young adults ESPs treatment. The real-time qPCR, western blotting were employed to detect the expression of apoptosis- and Shh pathway-related mol. The percentage of cell viability was monitored by CCK-8 assay. We demonstrated that expression of apoptosis-related mols. was increased in response to A. cantonensis young adults ESPs treatment. However, the cell viability of astrocytes was elevated by treatment with 3-HBA and 4-HBA. Further investigation found that 3-HBA and 4-HBA activate the Shh signaling pathway and inhibit apoptosis-related mol. expression. These findings were confirmed using A. cantonensis young adults ESPs to activate apoptosis-related pathways in astrocytes. Moreover, 3-HBA and 4-HBA induced a protective phenotype through regulation of apoptosis in response to A. cantonensis young adults ESPs treatment. Hence, 3-HBA and 4-HBA represent potential therapeutic drugs for the treatment of human angiostrongyliasis. The results came from multiple reactions, including the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Electric Literature of C7H6O2)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts