Category: 100-37-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Formula: C6H15NO

General procedure: In a typical procedure, a capped vessel was charged with ionic liquid BmimBF4 (0.5 mL) and put under positive pressure of nitrogen. DBU (0.5 mmol) and Cs2CO3 (1.5 mmol) were added followed by the aldehyde (0.5 mmol) and MnO2 (1.5 mmol). The reaction mixture was stirred for a few minutes and alcohol (1.5 mmol) was added. The reaction mixture was stirred at ambient temperature for 24 h. The mixture was then filtered through a thin pad of silica, which was washed with ethyl acetate (30 mL). The filtrate was analyzed by TLC and 1H NMR and then concentrated under vacuum. The resulting residue was purified by flash chromatography on silica gel where needed.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Article; Chiarotto, Isabella; Feroci, Marta; Sotgiu, Giovanni; Inesi, Achille; Tetrahedron; vol. 69; 37; (2013); p. 8088 – 8095;,
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Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To THF (2 mL) in microwave reaction vessel were added ethanol (0.059 mL, 1.0 mmol) and sodium hydride (32 mg, 1.3 mmol). After stirring for 30 min at room temperature, 2,6-dichloropyrazine (100 mg, 0.671 mmol) was added to the reaction mixture. The reaction mixture was heated in the microwave reactor at power 100 W and 50 C for 10 min. After solvents were removed under reduced pressure, the residue was dissolved in ethyl acetate. Organic layer was washed with water and dried over MgSO4.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; More, Kunal N.; Jang, Hyo Weon; Hong, Victor S.; Lee, Jinho; Bioorganic and Medicinal Chemistry Letters; vol. 24; 11; (2014); p. 2424 – 2428;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(Diethylamino)ethanol

diethylaminoethanol 11.7 g (0.1 mol) was dissolved in 10% sodium bicarbonate (200ml) and acetone (100ml). 2-(6-methoxy-2-naphthyl)propionyl chloride 24.9g (0.1mol) was added to the reaction mixture. The mixture is stirred for 3 hours at room temperature. The solvent is evaporated. The residue is suspended in ethyl acetate (500ml). 5% sodium bicarbonate (200ml) is added to the reaction mixture while stirring. The ethyl acetate layer was collected, washed with water (3 × 500ml). The resulting ethyl acetate solution was dried over anhydrous sodium sulfate. the sodium sulfate was removed by filtration. With stirring, acetic acid 6g was added to the reaction mixture. The organic solution was evaporated. After drying, the desired product 36g (89.9%) was obtained.

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Reference:
Patent; Techfields Biochem Company Limited; Yu, Chauncy; Shu, Rina; (52 pag.)JP2016/130241; (2016); A;,
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Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

34.9 g (0.1 mol) of 4-[l-(5,6,7,8 -tetrahydro- 3,5,5,8,8-pentamethyl -2-naphthalenyl) ethenyl] benzoic acid (bexarotene, Targretin ) was dissolved in 300 ml of chloroform. 20.6 g of N, N’-Dicyclohexylcarbodiimide was added into the reaction mixture. 11.6 g of dimethylaminoethanol was added into the reaction mixture. The mixture was stirred for 3 hours at RT. The solid was removed by filtration. The chloroform solution was washed with 5% NaHCO (2 x 100 ml) and water (3 x 100 ml). The organic solution was dried over anhydrous sodium sulfate. Sodium sulfate was removed by filtration. 3.6 g of HCl gas in ether (100 ml) was added into the reaction mixture with stirring. The solid product was collected by filtration. After drying, it yielded 40 g of the desired product (85.8%). Hygroscopic product; Elementary analysis: C H ClNO ; MW: 484.11. Calculated % C: 74.43; H: 8.74; Cl:30 42 27.32; N: 2.89; O: 6.61; Found % C: 74.39; H: 8.76; Cl: 7.29; N: 2.91, O: 6.65.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; YU, Chongxi; WO2008/87493; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., name: 2-(Diethylamino)ethanol

Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device were placed 12.8 g (0.1 mol) of adipic anhydride, 35.1 g (0.3 mol) of N, N-diethylaminoethanol,0.8gTitanyl sulfate, 20 mlXylene, stirring heated to 145 C refluxing reaction 3h, until the separation of 1.8g (0.1mol) water, remove the catalyst filter (direct reuse), the filtrate into another 250ml three bottles, vacuum distillation of solvent ), An excess amount of diethylaminoethanol (used for recovery), and a low boiling point substance were added, and 3.0 g of activated clay was added thereto. The mixture was stirred for 30 minutes, and the temperature was lowered to 80 C or less, and filtered to obtain a yellow oily liquid bisdiethylaminoethyl adipate 31.34 G, and the yield was 91.1%. And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed heated to 120 C, the citric acid after melting, stirring cooling crystallization salt, that is a white powder solid product adipic acid bis Diethylamino ethanolate citrate. Its melting point: 117 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 2-(Diethylamino)ethanol

General procedure: 1-(2,3-Dihydro-1,4-benzodioxin-6-yl)cyclopentane-1-carboxylate hydrochlorides 7a-7f were synthesized as described above for 6a-6e from 7 mmol of amino alcohol 5a-5f and 1.87 g (7 mmol) of acid chloride 3 in the presence of 0.7 g (7 mmol) of triethylamine. A solution of 1.3 g (5 mmol) of acid chloride 3 in 30 mL of anhydrous benzene was added with shaking to a mixture of 5 mmol of diamine 4a-4e and 0.5 g (5 mmol) of triethylamine in 50 mL of anhydrous benzene. The mixture was left to stand for 2 h at room temperature and was then refluxed for 10 h. After cooling, the mixture was treated with 3 mL of 15% aqueous sodium hydroxide with shaking, and the organic layer was separated, washed with water until neutral reaction, and dried. The solvent was distilled off, the residue was dissolved in diethyl ether, and a solution of dry HCl in diethyl ether was added. The precipitate was filtered off and recrystallized from ethanol.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Article; Arustamyan, Zh. S.; Markaryan; Aghekyan; Nazaryan; Hakobyan; Paronikyan; Minasyan; Russian Journal of Organic Chemistry; vol. 55; 6; (2019); p. 796 – 799; Zh. Org. Khim.; vol. 55; 6; (2019); p. 896 – 900,5;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H15NO

80 g of 2-acetylsalicylic acid was dissolved in 1000 ml of chloroform. The mixture was cooled to 5 C.103 g of 1,3-dicyclohexylcarbodiimide were added to the mixture. The mixture was stirred at room temperature for 2 hours.The solid waste was filtered off and washed with chloroform (3 x 300 ml).59 g of diethylaminoethanol was added to the reaction mixture.The mixture was stirred at room temperature for 3 hours. The organic solution was evaporated.After drying, 220 g of the desired product was obtained (96%).

With the rapid development of chemical substances, we look forward to future research findings about 100-37-8.

Reference:
Patent; TECHFIELDS INCORPORATED; YU, CHONGXI; XU, LINA; (79 pag.)JP5997658; (2016); B2;,
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Electric Literature of 100-37-8 ,Some common heterocyclic compound, 100-37-8, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: An oven dried 10 mL round bottom flask equipped with a stir bar was brought into the glove box with a reflux condenser. The flask was charged with [RuHCl(CO)(HN(CH2CH2PPh2)2)] (4) (6.0 mg, 0.01 mmol, 1mol%), KOH (8.2 mg, 0.15 mmol, 15mol%), toluene (1.0mL), an amine (1 mmol, 1.0 equiv), and an alcohol (1mmol, 1.0equiv) in that order. After all reagents have been added to the flask, the reflux condenser was attached and secured with a Keck clamp. The top of the condenser was sealed with a septum and the whole apparatus was then removed from the glove box. Once outside the glove box, the apparatus was equipped to nitrogen flow by inserting an inlet needle supplying a positive pressure of nitrogen into the septum, and an outlet needle connected to an oil bubbler. The reaction mixture was heated at reflux in a silicone oil bath overnight (12h), then allowed to cool to rt, and the conversion determined by GC-MS (CI). The resulting residue was subjected to flash chromatography with the indicated solvent system to obtain the purified amide in the reported isolated yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-37-8, 2-(Diethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Oldenhuis, Nathan J.; Dong, Vy M.; Guan, Zhibin; Tetrahedron; vol. 70; 27-28; (2014); p. 4213 – 4218;,
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Electric Literature of 100-37-8, Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol,molecular formula is C6H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8.

Valsartan 1.75 g (4.25 mmol),Dichloromethane 30mL,0.49 g (4.25 mmol) of 2- (diethylamino) ethanol was added to the reaction flask,After warming to reflux, 0.34 mL (4.25 mmol) of thionyl chloride,Reaction for 1 hour,HPLC detection reaction was complete,After treatment, the reaction mixture was evaporated to dryness under reduced pressure,Cooled to room temperature by adding 5mL of water,With sodium hydroxide solution to adjust pH = 9 ~ 10,Extract with 30 mL of dichloromethane,The combined organic layers were dried over anhydrous sodium sulfate,2.10 g of Compound (II) concentrated by filtration under reduced pressure were filtered off with a desiccant,Yield 92.5%.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kebeiyuan (Beijing) Bio-pharmaceutical Technology Co., Ltd.; Beijing Zhiyuan Technology Co., Ltd.; Liu Qi; Cheng Zengjiang; (46 pag.)CN107468685; (2017); A;,
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Application of 100-37-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Preparation of N,N-diethylaminoethyl 4-[bis(2-chloroethyl)amino] ben- zenebutyrate.HCl; [19] 30.4 g (0.1 mol) of 4-[bis(2-chloroethyl)amino]benzenebutanoic acid was dissolved in 300 ml of chloroform. 20.6 g of N, N’-Dicyclohexylcarbodiimide was added into the reaction mixture. 11.7 g of N,N-diethylaminoethanol and 0.2 g of 4-dimethylaminopyridine were added into the reaction mixture. The mixture was stirred overnight at 0C. The solid was removed by filtration. The chloroform solution was washed with water (1 x 100 ml), 5% NaHCO (1 x 100 ml) and water (3 x 100 ml). The organic solution was dried over anhydrous sodium sulfate. Sodium sulfate was removed by filtration. 4 g of HCl gas in methanol (10 ml) was added into the reaction mixture with stirring. Hexane (200 ml) was added. The solid product was collected by filtration. After drying, it yielded 35 g of the desired product (79.6 %). Hygroscopic product; Solubility in water: 300 mg/ml; Elementary analysis: C H Cl N 2O2; MW: 439.85. Calculated % C: 54.61, H: 7.56, N: 6.37; O: 7.27; Cl: 24.18; Found % C: 54.55; H: 7.58; N: 6.34, O: 7.29; Cl: 24.24. 1H-NMR (400 MHz, D O): delta: 1.56 (t, 6H), 2.01(m, 2H), 2.25 (m, 2H), 2.55 (m, 2H), 3.22 (m, 4H), 3.52 (m, 2H), 3.60-3.65 (m, 8H), 4.50 (m, 2H), 6.55 (m, 2H), 6.95 (m, 2H).

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TECHFIELDS BIOCHEM CO. LTD; YU, Chongxi; XU, Lina; WO2008/41059; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts