Author: tianli

Tuning Triplet Energy Transfer of Hydroxamates as the Nitrene Precursor for Intramolecular C(sp³)-H Amidation was written by Jung, Hoimin;Keum, Hyeyun;Kweon, Jeonguk;Chang, Sukbok. And the article was included in Journal of the American Chemical Society in 2020.Electric Literature of C9H9F3O This article mentions the following:

Reported herein is the design of a photosensitization strategy to generate triplet nitrenes and its applicability for the intramol. C-H amidation reactions. Substrate optimization by tuning phys. organic parameters according to the proposed energy transfer pathway led us to identify hydroxamates as a convenient nitrene precursor. While more classical nitrene sources, representatively organic azides, were ineffective under the current photosensitization conditions, hydroxamates, which are readily available from alcs. or carboxylic acids, are highly efficient in accessing synthetically valuable 2-oxazolidinones and 纬-lactams by visible light. Mechanism studies supported our working hypothesis that the energy transfer path is mainly operative. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Electric Literature of C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aminations of Aryl Bromides in Water at Room Temperature was written by Lipshutz, Bruce H.;Chung, David W.;Rich, Brian. And the article was included in Advanced Synthesis & Catalysis in 2009.Name: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Unsym. diarylamines and triarylamines R¹C₆H₄NR²R³ [R¹ = H, 4-NC, 4-O₂N, etc.; R² = H, Me, Ph; R³ = 4-FC₆H₄, 1-naphthyl, 2,4-(MeO)₂C₆H₃, etc.] were obtained via palladium-catalyzed amination at ambient temperatures in water. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Name: 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New insights into the thermal degradation behavior of Hydroxypropyl-beta-cyclodextrin inclusion complexes containing carvacrol essential oil via thermogravimetric analysis was written by Li, Zhe;Jiang, Xiaoxia;Zhu, Lin;Chen, Fucai;Liu, Hongning;Ming, Liangshan. And the article was included in Journal of Thermal Analysis and Calorimetry in 2022.Formula: C10H14O This article mentions the following:

The physicochem. properties and thermodn. parameters of cyclodextrin inclusion complexes (ICs) containing essential oil were investigated by thermogravimetric anal. It is necessary to understand the ICs thermal decomposition behavior and kinetics to control and elucidate the inclusion complexation mechanisms. Carvacrol essential oil was encapsulated with hydroxypropyl-beta-cyclodextrin (HP-尾 CD) using the freeze-drying method. The IC was characterized by SEM, FT-IR, and phase solubility, which confirmed that there were mol. interactions between the carvacrol essential oil and HP-尾 CD. Moreover, thermal experiments were carried out by a thermogravimetric analyzer at different heating rates (10-40 掳C min-1). In addition, three different models, i.e., FOW, KAS, and Starink, were used to calculate the kinetic energy. The FOW was a more proficient model for the calculation of activation energy (Ea). Further, the average values of Ea varied from conversion, and for carvacrol, HP-尾 CD, and carvacrol/HP-尾 CD IC, they were found to be 70.56, 162.15, and 152.57 kJ mol-1 based on the FOW model, resp. In general, carvacrol encapsulated into HP-尾 CD as an IC showed high thermal stability. The kinetic results could be useful in predicting the thermal performance of IC and in helping optimize exptl. procedures for the encapsulation of essential oils in cyclodextrins. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A catalytic stereo- and chemo-selective method for the reduction of substituted aromatics was written by Fache, Fabienne;Lehuede, Stephan;Lemaire, Marc. And the article was included in Tetrahedron Letters in 1995.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

Various substituted aromatics have been reduced using colloidal ruthenium under H₂ pressure with good stereoselectivity (cis/trans up to 60). Interesting chemoselectivities are also observed In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Research progress on the selective estrogen receptor modulators was written by Ding, Hao;Yang, Fan;Cai, Yi;Chai, Xiaoyun;Wu, Qiuye. And the article was included in Yaoxue Shijian Zazhi in 2016.Application of 128607-22-7 This article mentions the following:

Breast cancer had become the main malignant tumors which posed a serious threat to women’s health. Selective estrogen receptor modulators, which served as the effective drug treatment, had been attracting more attention. Present research progress on the selective estrogen receptor modulators was summarized in this paper. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Application of 128607-22-7).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 128607-22-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization was written by Marzi, Elena;Spitaleri, Andrea;Mongin, Florence;Schlosser, Manfred. And the article was included in European Journal of Organic Chemistry in 2002.Computed Properties of C9H9F3O This article mentions the following:

It was possible to functionalize the three fluorobenzyl alcs. and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an O-protective group making seven new fluorobenzoic acids, including I and II, accessible in 63% average yield. The TIPS group tolerates weakly basic and acidic media and may facilitate further structural elaboration. The unprotected alcs. reacted more sluggishly and were unable to provide two of the targeted products. The yield averaged only 46% in the five other cases. The direct metalation of fluorinated benzyl and phenethyl alcs. remains nevertheless an attractive option because of its operational simplicity. All three (trifluoromethyl)benzyl alcs. and two of the three (trifluoromethyl)phenethyl alc. isomers were successfully submitted to the metalation/functionalization sequence. These five starting materials gave rise to a total nine new benzoic acids or lactones, e.g. III. Despite the poor yields (31% on average), the employed organometallic methods are extremely regioselective, economical and easy to perform. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Computed Properties of C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets was written by Zheng, Ying;Chen, Zhi-yong;Ma, Wen-jun;Wang, Qiu-zhen;Liang, Hui;Ma, Ai-guo. And the article was included in Current Medical Science in 2021.Quality Control of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

Objective: To determine whether B vitamin treatment was sufficient to reduce cognitive impairment associated with high-fat diets in rats and to modulate transketolase (TK) expression and activity. To test this, we separated 50 rats into five groups that were either fed a standard chow diet (controls) or a high-fat diet (exptl. groups H0, H1, H2, and H3). H0 group animals received no addnl. dietary supplementation, while H1 group animals were administered 100 mg/kg body weight (BW) thiamine, 100 mg/kg BW riboflavin, and 250 mg/kg BW niacin each day, and group H2 animals received daily doses of 100 mg/kg BW pyridoxine, 100 mg/kg BW cobalamin, and 5 mg/kg BW folate. Animals in the H3 group received the B vitamin regimens administered to both H1 and H2 each day. Over time, group H0 exhibited greater increases in BW and fat mass relative to other groups. When spatial and memory capabilities in these animals were evaluated via conditioned taste aversion (CTA) and Morris Water Maze (MWM), we found B vitamin treatment was associated with significant improvements relative to untreated H0 controls. Similarly, B vitamin supplementation was associated with elevated TK expression in erythrocytes and hypothalamus of treated animals relative to those in H0 (P<0.05). Conclusion: Together, these findings suggest B vitamin can modulate hypothalamic TK activity to reduce the severity of cognitive deficits in a rat model of obesity. As such, B vitamin supplementation may be a beneficial method for reducing cognitive dysfunction in clin. settings associated with high-fat diets. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Quality Control of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides was written by Erigur, Esra Caner;Altug, Cevher;Angeli, Andrea;Supuran, Claudiu T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Synthetic Route of C4H10O3 This article mentions the following:

A series of novel 1,3-thiazole sulfonamides I [R = i-Pr, n-Bu, HOCH₂CH₂, Ph(CH₂)₄, etc.] has been designed, synthesized and studied their carbonic anhydrase (CA) inhibitory properties. The inhibition property of four human CA isoforms was investigated: hCA I, II, IX, and XII using the standard drug acetazolamide (AAZ) for comparison. The compounds I showed a wide range of inhibition potency towards the cytosolic enzyme hCA I. Nevertheless, the compounds I (R = n-Pr, i-Pr, HOCH₂CHMe, HOCHMeCH₂, MeOCH₂CH₂) have shown higher inhibition potential as compared to acetazolamide (KI = 250 nM). The abundant human cytosolic isoform, hCA II, was strongly inhibited by the most compounds in low nanomolar range (KI < 12.1 nM). On the other hand, almost all novel synthesized compounds have shown weaker inhibition potential as compared to acetazolamide against the tumor membrane- associated isoform hCA IX. Finally, the second tumor membrane-associated isoform, hCA XII, showed a wide range of potency that spanned from 9.3 to 729.6 nM. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Synthetic Route of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts