Author: tianli

Palladium-Catalyzed Annulation of Alkynes with Ortho-Halide-Containing Benzyl Alcohols in Aqueous Medium was written by Feng, Jie;Lu, Guoping;Lv, Meifang;Cai, Chun. And the article was included in Journal of Organic Chemistry in 2014.Synthetic Route of C7H6BrClO This article mentions the following:

The Pd-catalyzed annulations of ortho-halide-containing benzyl alcs. with alkynes for the synthesis of indenones were achieved in aqueous Triton X-100 micelles with good yields and wide substrate scopes. Moreover, the indenones obtained in this procedure can be further functionalized to form some more synthetic useful derivatives via an environmental-friendly way. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Synthetic Route of C7H6BrClO).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C7H6BrClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Base-induced Sommelet-Hauser rearrangement of N-(pyridinylmethyl) tetraalkylammonium salts was written by Tayama, Eiji;Shimizu, Goshu;Nakao, Ryo. And the article was included in Tetrahedron in 2022.Formula: C7H9NO This article mentions the following:

The base-induced Sommelet-Hauser (S-H) rearrangement of various types of N-(pyridinylmethyl) tetraalkylammonium salts to produce N,N-dialkyl-伪-pyridinylamino acid esters were investigated. For example, a treatment of N-(2-pyridinylmethyl) glycine tert-Bu ester-derived tetraalkylammonium salt with 1.2 equiv of potassium tert-butoxide in THF at -40掳C gave the corresponding S-H product, I [R = Obut; R¹ = R² = Me; R³= H] in 93% yield. Method was an efficient C-H functionalization of pyridines under simple and mild conditions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Formula: C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C7H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Facile Cu(OTf)₂-Catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-Pot Anomeric Substitution to Thioglycosides under Solvent-Free Conditions was written by Tai, Cheng-An;Kulkarni, Suvarn S.;Hung, Shang-Cheng. And the article was included in Journal of Organic Chemistry in 2003.Formula: C6H14O6 This article mentions the following:

Solvent-free per-O-acetylation of hexoses with a stoichiometric amount of acetic anhydride employing 0.03 mol % Cu(OTf)₂ proceeded in high yields (90-99%) at room temperature to give exclusively pyranosyl products as an anomeric mixture, the 伪/尾 ratio of which was dependent on the temperature and amount of catalyst used. Sequential anomeric substitution with p-thiocresol in the presence of BF₃路etherate gave the thioglycosides, isolated exclusively or predominantly as one anomer in 66-75% yields. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

CuO-Fe(III)-Zeolite-Y as efficient catalyst for oxidative alcohol-amine coupling reactions was written by Gogoi, Gautam;Baruah, Manash J.;Biswas, Subir;Hoque, Nazimul;Lee, Seonghwan;Park, Young-Bin;Saikia, Lakshi;Bania, Kusum K.. And the article was included in Molecular Catalysis in 2022.Application In Synthesis of (2,4-Dichlorophenyl)methanol This article mentions the following:

CuO nanocatalyst with layered structure was supported over Fe-exchanged zeolite-Y (CuO-Fe(III)-Y) for selective synthesis of amides by oxidative coupling of aromatic primary alcs. and amines. The CuO-Fe(III)-Y catalyst was characterized by different physicochem. and spectroscopic techniques. The amide bond formation reaction was found to occur in absence of any external base and reagents. The temperature-programmed desorption (TPD) study predicted the development of strong basic sites in the CuO-Fe(III)-Y catalyst that boosted the dehydrogenative coupling process. The activity of the material in such coupling reaction was found to be comparable to those of other costly metal catalysts under different reaction conditions. The product yield of the reaction was found to be substrate-dependent giving moderate to maximum yield of 85%. The anomalies in the reaction appeared in case of 5-nitro-2-chloro-benzylalc. that undergoes a C-N coupling product through C-Cl bond activation. The mechanism of the reaction was believed to proceed through FeIV=O species that helped in the activation of the benzylic C-H bond . In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application In Synthesis of (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polyol-assisted hydrothermal synthesis of Mn-doped 伪 – Fe₂O₃(MFO) nanostructures: Spin disorder-induced magnetism and photocatalytic properties. was written by Ramprasath, R.;Manikandan, Velu;Aldawood, S.;Sudha, S.;Cholan, S.;Kannadasan, N.;Sampath, Sridhar;Gokul, B.. And the article was included in Environmental Research in 2022.Computed Properties of C3H8O2 This article mentions the following:

Hierarchical nanostructures play an important role in environmental clean-up and sustainability applications. The magnetic and photocatalytic characteristics of flower-like Mn-doped 伪-Fe₂O₃ nanostructures were prepared by using a polyol-assisted hydrothermal method. Crystallite sizes are in the range of 35-42 nm, and the existence of 3D hierarchical nanostructures was observed in FESEM pictures. The optical band gap energy varies between 2.08 and 2.16 eV, while XPS examination exposes the ions’ charge states and validates Mn³⁺ inclusion in the Fe³⁺ lattice. At room temperature, the addition of Mn to 伪-Fe₂O₃ results in a spin disorder ferromagnetism and coercivity of about 600 Oe was achieved. Methylene blue (MB) dye solution degraded by 92% when 2.5% Mn doped with 伪-Fe₂O₃ under visible conditions for 120 min irradiation time. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Computed Properties of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electrochemistry of transition metal hydride diphosphine complexes trans-MH(X)(PP)₂ and trans-[MH(L)(PP)₂]⁺, M = Fe, Ru, Os; PP = chelating phosphine ligand was written by Drouin, Samantha D.;Maltby, Patricia A.;Rennie, Benjamin E.;Schweitzer, Caroline T.;Golombek, Adina;Cappellani, E. Paul;Morris, Robert H.. And the article was included in Inorganica Chimica Acta in 2021.Formula: C4H9NaS This article mentions the following:

A series of over 30 iron, ruthenium, and osmium hydride phosphine complexes are reported, along with their M^III/II redox potentials. The complexes are of the type MH(PP)_n(X) or [MH(PP)_n(L)]⁺, where PP is one of the following bidentate phosphine ligands: dppe, dtpe, depe, and dtfpe, with n = 2; or the tetradentate phosphine ligand meso-tet-1, with n = 1. The electrochem. data of these complexes and those from the literature are used to determine the Lever E_L parameter of -0.65 V for the hydride ligand for iron and ruthenium. For osmium, however, the E_L value for the hydride ligand is found to be more pos. at only -0.37 V, an increase which is attributed to Os-H 蟽 bond strengthening due to relativistic effects. The correlation holds for irreversible oxidations as well as reversible ones. These E_L values can now be used along with Lever’s equations to predict redox potentials of other iron-group hydride complexes. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Formula: C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray was written by Gardner, Wil;Hook, Andrew L.;Alexander, Morgan R.;Ballabio, Davide;Cutts, Suzanne M.;Muir, Benjamin W.;Pigram, Paul J.. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.Related Products of 4074-88-8 This article mentions the following:

Combinatorial approaches to materials discovery offer promising potential for the rapid development of novel polymer systems. Polymer microarrays enable the high-throughput comparison of material phys. and chem. properties-such as surface chem. and properties like cell attachment or protein adsorption-in order to identify correlations that can progress materials development. A challenge for this approach is to accurately discriminate between highly similar polymer chemistries or identify heterogeneities within individual polymer spots. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) offers unique potential in this regard, capable of describing the chem. associated with the outermost layer of a sample with high spatial resolution and chem. sensitivity. However, this comes at the cost of generating large scale, complex hyperspectral imaging data sets. We have demonstrated previously that machine learning is a powerful tool for interpreting ToF-SIMS images, describing a method for color-tagging the output of a self-organizing map (SOM). This reduces the entire hyperspectral data set to a single reconstructed color similarity map, in which the spectral similarity between pixels is represented by color similarity in the map. Here, we apply the same methodol. to a ToF-SIMS image of a printed polymer microarray for the first time. We report complete, single-pixel mol. discrimination of the 70 unique homopolymer spots on the array while also identifying intraspot heterogeneities thought to be related to intermixing of the polymer and the pHEMA coating. In this way, we show that the SOM can identify layers of similarity and clusters in the data, both with respect to polymer backbone structures and their individual side groups. Finally, we relate the output of the SOM anal. with fluorescence data from polymer-protein adsorption studies, highlighting how polymer performance can be visualized within the context of the global topol. of the data set. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Related Products of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Severe bullous allergic contact dermatitis caused by glycidyl methacrylate and other acrylates was written by Vogel, Tatiana Alexandra;Christoffers, Wietske Andrea;Engfeldt, Malin;Bruze, Magnus;Coenraads, Pieter-Jan;Schuttelaar, Marie-Louise Anna. And the article was included in Contact Dermatitis in 2014.Product Details of 4074-88-8 This article mentions the following:

A research illustrates a rarer case of a severe allergic contact dermatitis caused by acrylates glycidyl methacrylate and 1,6 hexanediol diacrylate in an occupational setting. The multiple reactivity to various acrylates in this patient can be explained by two different phenomena: cross-reactivity, and sub sequent exposure to other acrylates. This case report reveals the importance of patch testing with a dilution series of acrylates to distinguish between a contact allergy and an irritant reaction. And moreover, it emphasizes the importance of investigating the products in a patient’s workplace and testing the purity of these products. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Product Details of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities was written by Wang, Wang;Xiong, Liangliang;Li, Yutong;Song, Zhuorui;Sun, Dejuan;Li, Hua;Chen, Lixia. And the article was included in Bioorganic & Medicinal Chemistry in 2022.Reference of 111-46-6 This article mentions the following:

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties I [R = Et, phenyl; R¹ = Me, Cl, F, etc], II [R² = Me, Ph, cyclohexyl, etc.] and III [R³ = Bu, butyne, 1,4-dimethylbenzene, etc.] . Biol. evaluation indicated that compound III [R³ = ethoxyethane] exhibited excellently inhibitory activity on LPS-induced NO production in RAW264.7 cells (IC₅₀ = 0.38 卤 0.18 渭M). The preliminary structure-activity relationships (SARs) suggested that phenylsulfonyl substituted furoxan moiety had the strongest ability to improve anti-inflammatory activity of lathyrane diterpenoids. Furthermore, compound III [R³ = ethoxyethane] significantly reduced the level of ROS. Its mol. mechanism was related to inhibiting the transcriptional activation of Nrf₂/HO-1 pathway. Based on these considerations, III [R³ = ethoxyethane] might be a promising anti-inflammatory agent, which is noteworthy for further exploration. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Reference of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In vitro and in vivo biocompatibility of novel zwitterionic poly(beta amino)ester hydrogels based on diacrylate and glycine for site-specific controlled drug release was written by Filipovic, Vuk V.;Babic, Marija M.;Godevac, Dejan;Pavic, Aleksandar;Nikodinovic-Runic, Jasmina;Tomic, Simonida Lj.. And the article was included in Macromolecular Chemistry and Physics in 2019.Reference of 4074-88-8 This article mentions the following:

New (尾-aminoester) hydrogels (PBAE) based on di(ethylene glycol)diacrylate and glycine are successfully synthesized and characterized for the first time in this work. PBAE macromers are obtained using Michael addition By changing the diacrylate/amine stoichiometric ratio, but maintaining it >1, samples with different chem. structure containing acrylate end-groups are obtained. The hydrogels are synthesized from macromers utilizing free radical polymerization Chem. structure of macromers and hydrogels is confirmed by proton NMR, and Fourier transform infra-red spectroscopy. Swelling and degradation rates in physiol. pH range change notably with pH and monomer molar ratio, validating pH sensitivity and zwitterionic behavior, which can be finely tuned by changing any of these parameters. In vitro cytotoxicity and in vivo acute embryotoxicity in zebrafish (Danio rerio) performed to assess the biocompatibility of the novel hydrogel materials and their degradation products reveal that materials are nontoxic and biocompatible. The Cephalexin in vitro drug release study, at pH values 2.20, 5.50, and 7.40, demonstrates pH-sensitive delivery with the release profiles effectively controlled by pH and the hydrogel composition PBAE hydrogels exhibit great potential for a variety of biomedical applications, including tissue regeneration and intelligent drug delivery systems. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts