Author: tianli

Selectfluor-Enabled C(sp³)-H Alkoxylation of 3-Methylfuranocoumarins was written by Qin, Zengxin;Zhao, Mengfei;Zhang, Kaixin;Goto, Masuo;Lee, Kuo-Hsiung;Li, Jizhen. And the article was included in Journal of Organic Chemistry in 2021.COA of Formula: C7H6Cl2O This article mentions the following:

A facile and metal-free method for the direct C(sp³)-H bond alkoxylation of 3-methylfuranocoumarins I (R = H, Me, NO₂; R¹ = H; R² = H; R¹R² = -CH=CH-CH=CH-; R³ = H, Me) and 4,17-dimethyl-11,15-dioxacyclopenta[a]phenanthren-12-one with alcs. R⁴OH (R⁴ = iso-Pr, cyclopentyl, 3-(2-bromophenyl)propyl, etc.) has been disclosed. Selectfluor enabled the (hetero)benzylic C-H etherification by tuning the reaction temperature and solvent. Various alcs. were compatible in this transformation with suitable yields. The mechanistic studies revealed that the reaction might undergo the double addition process of alcs., as well as the departure of a fluoride anion and the formation of an oxonium ion. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8COA of Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C7H6Cl2O

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Controlled self-assembly into diverse stimuli-responsive microstructures: from microspheres to branched cylindrical micelles and vesicles was written by Zhou, Xiaoteng;Li, Lingxiao;Qin, He;Ning, Bo;Li, Junpei;Kan, Chengyou. And the article was included in RSC Advances in 2018.Application of 60463-12-9 This article mentions the following:

A series of amphiphilic PDMAEMA-SS-PCL chains with variable ratios of hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) to hydrophobic poly(蔚-caprolactone) (PCL) were prepared via ring-opening polymerization, in which the two different moieties were linked via a disulfide bond with reduction responsiveness. After crosslinking by the photodegradable o-nitrobenzyl linkage, the amphiphilic chains could self-assemble into microspheres, branched cylindrical micelles and vesicles, which were responsive to the reduction agent DL-dithiothreitol and UV light irradiation through different mechanisms. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 60463-12-9

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Ospemifene 12-month safety and efficacy in postmenopausal women with vulvar and vaginal atrophy was written by Goldstein, S. R.;Bachmann, G. A.;Koninckx, P. R.;Lin, V. H.;Portman, D. J.;Ylikorkala, O.. And the article was included in Climacteric in 2014.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

Objective: Assessment of 12-mo safety of ospemifene 60 mg/day for treatment of postmenopausal women with vulvar and vaginal atrophy (VVA). Methods: In this 52-wk, randomized, double-blind, placebo-controlled, parallel-group study, women 40-80 years with VVA and an intact uterus were randomized 6 : 1 to ospemifene 60 mg/day or placebo. The primary objective was 12-mo safety, particularly endometrial; 12-wk efficacy was assessed. Safety assessments included endometrial histol. and thickness, and breast and gynecol. examinations Efficacy evaluations included changes from baseline to week 12 in percentage of superficial and parabasal cells and vaginal pH. Results: Of 426 randomized subjects, 81.9% (n =349) completed the study with adverse events the most common reason for discontinuation (ospemifene 9.5%; placebo 3.9%). Most (88%) treatment-emergent adverse events with ospemifene were considered mild or moderate. Three cases (1.0%) of active proliferation were observed in the ospemifene group. For one, active proliferation was seen at end of study week 52, and diagnosed as simple hyperplasia without atypia on follow-up biopsy 3 mo after the last dose. This subsequently resolved with progestogen treatment and dilatation and curettage. In six subjects (five ospemifene (1.4%), one placebo (1.6%)) endometrial polyps were found (histopathol.); however, only one (ospemifene) was confirmed as a true polyp during addnl. expert review. Endometrial histol. showed no evidence of carcinoma. Statistically significant improvements were seen for all primary and secondary efficacy measures and were sustained through week 52 with ospemifene vs. placebo. Conclusions: The findings of this 52-wk study confirm the tolerance and efficacy of oral ospemifene previously reported in short- and long-term studies. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

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Anti-insulin resistance effect of constituents from Senna siamea on zebrafish model, its molecular docking, and structure-activity relationships was written by Nuankaew, Wanlapa;Heemman, Armad;Wattanapiromsakul, Chatchai;Shim, Ji Heon;Kim, Na Woo;Yasmin, Tamanna;Jeong, Seo Yule;Nam, Youn Hee;Hong, Bin Na;Dej-adisai, Sukanya;Kang, Tong Ho. And the article was included in Journal of Natural Medicines in 2021.Recommanded Product: 10083-24-6 This article mentions the following:

Senna siamea has been used as an antidiabetic drug since antiquity. With regard to traditional Thai medicine, the use of S. siamea was described for diabetes therapy. To understand the mol. mechanism regarding insulin resistance. Pure compounds were isolated from wood extract We studied their biol. activities on insulin-resistance using an in vivo zebrafish model. We also performed an in silico study; mol. docking, and in vitro study by taking advantage of the enzyme inhibitory activities of 伪-glucosidase, PTP1B, and DPP-IV. Based on the preliminary investigation that Et acetate and ethanol extracts have potent effects against insulin resistance on zebrafish larvae, five compounds were isolated from two fractions following: resveratrol, piceatannol, dihydropiceatannol, chrysophanol, and emodin. All of the isolated compounds had anti-insulin resistance effects on zebrafish larvae. Resveratrol, piceatannol, and dihydropiceatannol also demonstrated inhibitory effects against 伪-glucosidase. Chrysophanol and emodin inhibited PTP1B activity, while resveratrol showed a DPP-IV inhibition effect via the mol. docking. The results of enzyme assay were similar. In conclusions, S. siamea components demonstrated effects against insulin resistance. The chem. structure displayed identical biol. activity to that of the compounds Therefore, S. siamea wood extract and their components are potential therapeutic options in the treatment of diabetes. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 10083-24-6

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Alcohol – Wikipedia,
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Chemoenzymatic Deracemization of Secondary Alcohols by using a TEMPO-Iodine-Alcohol Dehydrogenase System was written by Mendez-Sanchez, Daniel;Mangas-Sanchez, Juan;Lavandera, Ivan;Gotor, Vicente;Gotor-Fernandez, Vicente. And the article was included in ChemCatChem in 2015.Computed Properties of C8H9ClO This article mentions the following:

A deracemization system for secondary alcs. was established after the anal. of individual steps and their compatibility in one pot. The chem. oxidation and bioreduction occurred in a sequential manner to yield 1-arylethanols and lineal aliphatic alcs. with excellent conversions and enantiomeric excess values. The oxidation step was performed by using 2,2,6,6-tetramethylpiperidin-1-oxyl and iodine. This chem. process was extremely favored by sonication, which allowed quant. formation of the corresponding ketone intermediates after just 1 h. Simple destruction of iodine in the same pot allowed sequential bioreduction of the ketones by using either Prelog or antiPrelog enzymes, which led to the preparation of the enantiopure alcs. in excellent yields. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Computed Properties of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C8H9ClO

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Alcohol – Wikipedia,
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An investigation by thermal analysis of glycosidic natural sweeteners was written by Santana, Naienne da S.;Mothe, Cheila G.;de Souza, Marcio Nele;Mothe, Michelle G.. And the article was included in Journal of Thermal Analysis and Calorimetry.Formula: C4H10O4 This article mentions the following:

The demand for non-nutritive sweeteners of natural origin has increased in recent years, mainly driven by health concerns and the quest for a healthier lifestyle. This work aimed to investigate the content of steviol glycosides from Stevia rebaudiana Bertoni and cucurbitane glycosides from monk fruit in com. samples of sweeteners using thermal anal. techniques (TG/DTG, DTA, and DSC), FTIR, EDS. Four com. samples were analyzed based on steviol glycosides (E, E2, E3, E4) and one sample based on cucurbitane glycosides (M1). The thermogravimetry (TG) results showed that the thermal stability order of the samples till 200 掳C was equal to E4 > M1 鈮?E2 > E > E3. Despite being marketed based on different natural glycosides, thermal anal. techniques showed similar thermal profiles between E2 and M1 samples. The DSC curves of these samples showed clear erythritol melting events, and the FTIR spectra confirmed the presence of this polyol in E2 and M1 samples. On the other hand, the DSC curve and the FTIR spectrum confirmed the presence of xylitol in the composition of the E4 sample. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Formula: C4H10O4).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C4H10O4

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Alcohol – Wikipedia,
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Biochar and super absorbent polymer improved growth, yield, and phytochemical characteristics of Satureja rechingeri Jamzad in water-deficiency conditions was written by Beiranvandi, Mojgan;Akbari, Nasser;Ahmadi, Abdolreza;Mumivand, Hasan;Nazarian, Farhad. And the article was included in Industrial Crops and Products in 2022.Name: 5-Isopropyl-2-methylphenol This article mentions the following:

Biochar is a stable, carbon-rich byproduct of organic matter thermal degradation The application of biochar demonstrates improved soil properties, water holding capacity, crop plant growth, and nutrient retention. The purpose of this study was to determine the effect of biochar and super absorbent on several phytochem. parameters of S. rechingeri Jamzad when grown in a water-stressed conditions. During two consecutive cropping seasons (2017-2019), an experiment was conducted using a split-plot factorial design with a randomized complete block design in three replications. Irrigation (100%, 80%, and 60% of irrigation requirement) [I] was used in the main plots, while subplots received a combination of two levels of cow manure biochar (0 and 10 t ha-1) [B] and two levels of stockosorb super absorbent (0 and 60 mg per plant) [SA]. Despite the relatively high diversity of compounds found in savory essential oils, the mean comparison revealed that IxBxSA had a significant effect on the majority of the primary components found in savory essential oils. Carvacrol (67.2-85%) was the first major constituent of savory essential oils in the two years, followed by 1, 8-cineole, terpinen-4-ol, 纬-terpinene, and linalool. The exptl. results indicated that drought stress increased the percentage of essential oil in two years but decreased dry matter and essential oil yield. Evidently, biochar and SA alone exhibit a similar effect on the content of savory essential oils, increasing growth rate and essential oil content (%). In general, this study confirmed that the combination of biochar and SA resulted in the highest savory leaf area, dry weight, and essential oil yield when compared to the application of biochar or SA alone under drought stress conditions. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Name: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
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Ospemifene for the treatment of menopausal vaginal dryness, a symptom of the genitourinary syndrome of menopause was written by Archer, David F.;Simon, James A.;Portman, David J.;Goldstein, Steven R.;Goldstein, Irwin. And the article was included in Expert Review of Endocrinology & Metabolism in 2019.SDS of cas: 128607-22-7 This article mentions the following:

: Vulvovaginal atrophy (VVA), a component of the genitourinary syndrome of menopause, is a progressive condition due to decline in estrogen leading to vaginal and vulvar epithelial changes. Accompanying symptoms of dryness, irritation, burning, dysuria, and/or dyspareunia have a neg. impact on quality of life. Ospemifene is a selective estrogen receptor modulator (SERM) approved by the FDA for moderate to severe dyspareunia and vaginal dryness due to postmenopausal VVA.: PubMed was searched from inception to March 2019 with keywords ospemifene and vulvar vaginal atrophy to review preclin. and clin. data describing the safety and efficacy of ospemifene for vaginal dryness and dyspareunia due to VVA. Covered topics include efficacy of ospemifene on vaginal cell populations, vaginal pH, and most bothersome VVA symptoms; imaging studies of vulvar and vaginal tissues; effects on sexual function; and safety of ospemifene on endometrium, cardiovascular system, and breast.: Ospemifene is significantly more effective than placebo in all efficacy analyses studied, working through estrogen receptors and possibly androgen receptors. Safety as assessed by adverse events was generally comparable to that with placebo and to other SERMs, and/or adverse events were not clin. meaningful. No cases of endometrial or breast cancer were reported. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7SDS of cas: 128607-22-7).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 128607-22-7

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Alcohol – Wikipedia,
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Unsymmetrical Diborane(4) Derivatives: A Comparative Study was written by Borner, Corinna;Wiecha, Maximilian T.;Kleeberg, Christian. And the article was included in European Journal of Inorganic Chemistry in 2017.HPLC of Formula: 1214264-88-6 This article mentions the following:

Since its introduction in 2010 by Suginome et al., pinB-Bdan [pin = OCMe₂CMe₂O, dan = (NH)₂(C₁₀H₆)] has become a valuable reagent in various regioselective (bis)borylation reactions, and related unsym. diborane(4) derivatives were used as versatile precursors for diaminoboryl complexes. However, the unsym. diborane(4) derivatives employed show little variation of the diol and diamine moieties. The present study expands this class of compounds and reports the synthesis of unsym. diborane(4) derivatives [C₂H₄(tBuN)₂]B-B(NMe₂)₂ and [C₂H₄(tBuN)₂]B-B(NMe₂)Cl, bearing a sterically demanding nonaromatic diamine moiety, as well as [C₆H₄(HN)₂]B-B(O₂C₅H₁₀), [C₆H₄(HN)₂]B-B(O₂C₂H₄), and [C₆H₄(HN)₂]B-B[O₂C₆H₂(C₂H₉)₂], which illustrate the variability of the diol moiety. Fully characterization of all compounds including single-crystal x-ray diffraction studies allows for the 1st time a comparative discussion of the spectroscopic and structural properties of this class of compounds In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6HPLC of Formula: 1214264-88-6).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 1214264-88-6

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Alcohol – Wikipedia,
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Creation of a Nonsymmetric Dimethanolpyridine Ligand: A Rare Zn(salphen) Template Effect was written by Escudero-Adan, Eduardo C.;Benet-Buchholz, Jordi;Kleij, Arjan W.. And the article was included in Inorganic Chemistry in 2008.HPLC of Formula: 1122-71-0 This article mentions the following:

An interesting reversible, templated synthesis of unsym. pyridine-ligated Zn complexes was observed in solution and solid-state phases when Zn(salphen) complexes are reacted with MeOH-substituted pyridine substrates. The x-ray mol. structure of an unusual Zn₃ supramol. assembly is reported, in which the central Zn atom is embedded in a distorted octahedral geometry and each of the single anionic O atoms of the pyridine groups coordinates to a Zn(salphen) unit. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0HPLC of Formula: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 1122-71-0

Referemce:
Alcohol – Wikipedia,
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