Author: tianli

Discovery of practical production processes for arylsulfur pentafluorides and their higher homologs, bis- and tris-(sulfur pentafluorides): beginning of a new era of super-trifluoromethyl arene chemistry and its industry was written by Umemoto, Teruo;Garrick, Lloyd M.;Saito, Norimichi. And the article was included in Beilstein Journal of Organic Chemistry in 2012.Application of 29364-29-2 This article mentions the following:

Various arylsulfur pentafluorides, ArSF₅, have long been desired in both academic and industrial areas and ArSF₅ compounds have attracted considerable interest in many areas such as medicine, agrochems., and other new materials, since the highly stable SF₅ group is considered a super-trifluoromethyl group due to its significantly higher electronegativity and lipophilicity. This article describes the first practical method for the production of various arylsulfur pentafluorides and their higher homologs, bis- and tris-(sulfur pentafluorides), from the corresponding diaryl disulfides or aryl thiols. The method consists of two steps: (step 1) treatment of a diaryl disulfide or an aryl thiol with chlorine in the presence of an alkali metal fluoride and (step 2) treatment of the resulting arylsulfur chlorotetrafluoride with a fluoride source, such as zinc fluoride (ZnF₂), hydrofluoric acid (HF) and antimony fluorides, Sb(III/V) fluorides. The intermediate arylsulfur chlorotetrafluoride derivatives were isolated by distillation or recrystallization and characterized. The aspects of these new reactions are revealed and reaction mechanisms are discussed. As the method offers considerable improvement over previous methods in cost, yield, practicality, applicability and large-scale production, the new processes described here can be employed as the first practical method for the economical production of various arylsulfur pentafluorides and their higher homologs, which could then open up a new era of super-trifluoromethyl arene chem. and its applications in many areas. A reaction (chlorine/potassium fluoride) of bis(2,3,6-trifluorophenyl)disulfide (I) gave trans-chlorotetrafluoro(2,3,6-trifluorophenyl)sulfur (II) and cis-chlorotetrafluoro(2,3,6-trifluorophenyl)sulfur (III). The synthesis of the target compound was achieve by the treatment of II, III with fluorination agents, to provide, e.g., pentafluoro(2,3,6-trifluorophenyl)sulfur (IV). In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine was written by Yang, Gao-feng;Li, Guang-xun;Huang, Jin;Fu, Ding-qiang;Nie, Xiao-kang;Cui, Xin;Zhao, Jin-zhong;Tang, Zhuo. And the article was included in Journal of Organic Chemistry in 2021.Computed Properties of C9H9F3O This article mentions the following:

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chem. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with sym. and unsym. o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1). In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Computed Properties of C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1 was written by Zhang, Xiaoyan;Urbanski, Maud;Patel, Mona;Zeck, Roxanne E.;Cox, Geoffrey G.;Bian, Haiyan;Conway, Bruce R.;Beavers, Mary Pat;Rybczynski, Philip J.;Demarest, Keith T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Application of 1634-34-0 This article mentions the following:

A series of benzo-fused heteroaryl-O-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Indole-O-glucoside and benzimidazole-O-glucoside exhibited potent in vitro SGLT2 inhibitory activity. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Application of 1634-34-0).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 1634-34-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scope and limitations of montmorillonite K 10 catalyzed opening of epoxide rings by amines was written by Chakraborti, Asit K.;Kondaskar, Atul;Rudrawar, Santosh. And the article was included in Tetrahedron in 2004.HPLC of Formula: 40571-86-6 This article mentions the following:

Montmorillonite K 10 efficiently catalyzes the opening of epoxide rings by amines in high yields with excellent regio- and diastereoselectivities under solvent-free conditions at room temperature affording an improved process for synthesis of 2-amino alcs. Reaction of cyclohexene oxide with aryl/alkyl amines leads to the formation of trans-2-aryl/alkylaminocyclohexanols. For unsym. epoxides, the regioselectivity is controlled by the electronic and steric factors associated with the epoxide and the amine. Selective nucleophilic attack at the benzylic carbon of styrene oxide takes place with aromatic amines, whereas, aliphatic amines exhibit preferential nucleophilic attack at the terminal carbon. Aniline reacts selectively at the less hindered carbon of other unsym. epoxides. The difference in the internal strain energy of the epoxide ring in cycloalkene oxides and alkene oxides led to selective nucleophilic opening of cyclohexene oxide by aniline in the presence of styrene oxide. Due to the chelation effect, selective activation of the epoxide ring in 3-phenoxypropylene oxide takes place in the presence of styrene oxide leading to preferential cleavage of the epoxide ring in 3-phenoxypropylene oxide by aniline. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6HPLC of Formula: 40571-86-6).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 40571-86-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Assessment of the Nutritional Value of Traditional Vegetables from Southern Chile as Potential Sources of Natural Ingredients was written by Opazo-Navarrete, Mauricio;Burgos-Diaz, Cesar;Soto-Cerda, Braulio;Barahona, Tamara;Anguita-Barrales, Fresia;Mosi-Roa, Yohanna. And the article was included in Plant Foods for Human Nutrition (New York, NY, United States) in 2021.Quality Control of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

There is an increasing interest in consuming healthy foods motivated by the need of boosting the immune system naturally. In this sense, vegetables rich in bioactive compounds are a clear example of “superfoods” that promotes overall health and strengthen the immune response. Therefore, in this study eight traditional vegetables usually produced in southern Chile (pea, corn, carrot, leek, spinach, chard, coriander and parsley) were characterized in terms of their nutritional composition to evaluate their potential as lyophilized natural ingredients. Thus, chem. composition, amino acid profile, minerals, vitamins, carotenoids, polyphenols and pesticide residues were evaluated. Green leafy vegetables resulted to be an excellent source of proteins and dietary fibers as well as vitamins (ascorbic acid, choline, alpha-tocopherol and niacin), minerals (calcium, phosphorus and iron), carotenoids and polyphenols. Among the eight vegetables assessed spinach exhibited the more balanced nutritional profile. Moreover, 332 pesticide residues were analyzed and only six were detected in a low concentration Due to their nutritional properties, the present results suggest that vegetables produced in southern Chile could be considered as promising alternatives to develop natural food ingredients. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Quality Control of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Siliconized silsesquioxane-based nonstick molds for ultrahigh-resolution lithography was written by Lee, Bong Kuk;Park, Kun-Sik;Kim, Dong-Pyo;Ryu, Jin-Hwa;Park, Jaehoon;Jeong, Ye-Sul;Baek, Kyu-Ha;Do, Lee-Mi. And the article was included in Journal of Materials Chemistry in 2012.Quality Control of Diethyleneglycoldiacrylate This article mentions the following:

A material approach to fabricating high-performance nonstick molds for manufacturing ultrahigh-resolution features (<8 nm) is presented. Low-viscosity liquid blends (4-121 cP) consisting of siliconized silsesquioxane acrylate (Si-SSQA) with low surface energy and difunctional acrylics were used as nonstick replica-molds materials. The cured Si-SSQA-acrylic networks showed a high UV transparency (>92% at 365 nm), high modulus and wide-range modulus tunability (0.757-4.192 GPa), high resistance to organic solvents (<1.2 wt%), low shrinkage (<3%), and high water contact angle (91-103掳). The Si-SSQA-acrylic blends with a nonstick property were easily transferred to high-resolution replica molds (forms) with sub-25 nm features, a pitch of 25 nm and a height of 100 nm, even if the release agent was not modified onto the master. In addition, nonstick replica molds with a low concentration of uncross-linked (meth)acrylate showed the ability to duplicate ultrasmall nanostructures with a sub-8 nm parallel line, a pitch of 17 nm and a height of 6-7 nm. Furthermore, the Si-SSQA-based replica molds (forms) (forms) prevented the formation of bubble defects during imprinting owing to sufficient gas permeability. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Quality Control of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

伪-Oxygenation of Benzylic Ethers to Esters Using MnO_x-N@C Catalyst was written by Liu, Jing;Wan, Cong;Zheng, Aili;Wang, Lianyue;Yin, Kaiyue;Liu, Dandan;Wang, Shengde;Ren, Lanhui;Gao, Shuang. And the article was included in Youji Huaxue in 2019.Name: (2,4-Dichlorophenyl)methanol This article mentions the following:

A catalytic system for the oxidation of benzylic ethers 2-R-3-R¹-4-R²-5-R³-6-R⁴C₆CH₂OR⁵ (R = H, OH, Cl, OMe, etc.; R¹ = H, Me, OMe, CF₃; RR¹ = -CH=CH-CH=CH-; R² = H, i-Pr, Cl, Ph, etc.; R¹R² = -OCH₂O-; R³ = H; R⁴ = H, Cl; R³R⁴ = -CH=CH-CH=CH-; R⁵ = Me, Et, Bn; R⁴R⁵ = -(CH₂)₂-, -CH₂-) to esters 2-R-3-R¹-4-R²-5-R³-6-R⁴C₆C(O)OR⁵ has been developed utilizing reusable MnO_x-N@C as catalyst and tert-Bu hydroperoxide (TBHP) as benign oxidant under neat condition. The catalytic oxidation system has good functional groups tolerance and excellent chemoselectivity, and this catalytic procedure can also be scaled up. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Name: (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fine tuning of the orifice size of an open-cage fullerene by placing selenium in the rim: insertion/release of molecular hydrogen was written by Chuang, Shih-Ching;Murata, Yasujiro;Murata, Michihisa;Mori, Sadayuki;Maeda, Shuhei;Tanabe, Fumiyuki;Komatsu, Koichi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Name: Sodium 2-methyl-2-propanethiolate This article mentions the following:

A newly synthesized open-cage fullerene containing Se in the rim of the 13-membered-ring orifice allows milder conditions for H insertion, and the rate for H release is ca. three times faster than its S analog. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Name: Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microbial transformation of nitrogen-containing heterocyclic compounds. I. Hydroxylation of isomeric mono- and dimethylpyridines by microscopic fungi was written by Modyanova, L. V.;Vorob’eva, L. I.;Shibilkina, O. K.;Dovgilevich, E. V.;Terent’ev, P. B.;Kost, A. N.. And the article was included in Biotekhnologiya in 1990.HPLC of Formula: 102074-19-1 This article mentions the following:

By screening a number of museum microorganism cultures a group of microscopic fungi active in transforming mono- and dimethylpyridines was detected. It is only the Me substituent that undergoes oxidation, not the pyridine ring itself. Peculiarities of oxidative transformation of isomeric mono- and dimethylpyridines to the corresponding hydroxymethylpyridines were elucidated. For methylpyridines the pyridylcarbinol yield was independent of the Me substituent position. For dimethylpyridines only 1 Me group is subjected to hydroxylation, the ratio of the pyridylcarbinols obtained mainly depending on the substituent arrangement in the pyridine ring. In the experiment, the researchers used many compounds, for example, (5-Methylpyridin-3-yl)methanol (cas: 102074-19-1HPLC of Formula: 102074-19-1).

(5-Methylpyridin-3-yl)methanol (cas: 102074-19-1) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 102074-19-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts