Author: tianli

Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water was written by Hu, Wenkang;Zhang, Yilin;Zhu, Haiyan;Ye, Dongdong;Wang, Dawei. And the article was included in Green Chemistry in 2019.Reference of 1777-82-8 This article mentions the following:

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Reference of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aerobic oxidation of primary alcohols catalyzed by copper complexes of 1,10-phenanthroline-derived ligands was written by Das, Oindrila;Paine, Tapan Kanti. And the article was included in Dalton Transactions in 2012.Name: 6-Methyl-2-pyridinemethanol This article mentions the following:

Five copper complexes [(L¹)₂Cu(H₂O)](ClO₄)₂ (1), [(L¹)Cu(H₂O)₃](ClO₄)₂ (1a), [(L³)₂Cu(H₂O)](ClO₄)₂ (2), [(L⁵)₂Cu(H₂O)](ClO₄)₂ (3) and [(L⁶)₂Cu](ClO₄) (4) (where L¹ = 1,10-phenanthroline, L³ = 1,10-phenanthroline-5,6-dione, L⁵ = 1,10-phenanthrolinefuroxan and L⁶ = 2,9-dimethyl-1,10-phenanthrolinefuroxan), and in situ prepared copper complexes of 2,9-dimethyl-1,10-phenanthroline (L²) or 2,9-dimethyl-1,10-phenanthrolinedione (L⁴) were used for aerial oxidation of primary alcs. to the corresponding aldehydes under ambient conditions. The copper catalysts have been found to catalyze a series of primary alcs. including one secondary alc. with moderate turnover numbers and selectivity towards primary alcs. Copper(ii) complexes 1 (or 1a) and 2 were found to be the better catalysts among all other systems explored in this study. A copper(ii)-superoxo species is implicated to initiate the oxidation reaction. Structural and electronic factors of 1,10-phenanthroline-based ligands affecting the catalytic results for aerial oxidation of alcs. are discussed. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Name: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 6-Methyl-2-pyridinemethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fluorescent Polystyrene Microbeads as Invisible Security Ink and Optical Vapor Sensor for 4-Nitrotoluene was written by Sonawane, Swapnil L.;Asha, S. K.. And the article was included in ACS Applied Materials & Interfaces in 2016.SDS of cas: 4074-88-8 This article mentions the following:

Color-tunable solid-state emitting polystyrene (PS) microbeads were developed by dispersion polymerization, which showed excellent fluorescent security ink characteristics along with sensitive detection of vapors of nitro aromatics like 4-nitro toluene (4-NT). The fluorophores pyrene and perylenebisimide were incorporated into the PS backbone as acrylate monomer and acrylate cross-linker, resp. Solid state quantum yields of 94 and 20% were observed for the pyrene and perylenebisimide, resp., in the PS/Py and PS/PBI polymers. The morphol. and solid state fluorescence was measured by SEM, fluorescence microscopy, and absorbance and fluorescence spectroscopy techniques. The ethanol dispersion of the polymer could be used directly as a fluorescent security “invisible” ink, which became visible only under UV light. The color of the ink could be tuned depending on the amounts of the pyrene and perylenebisimide incorporated with blue and orange-green for pyrene alone or perylenebisimide alone beads resp. and various shades in between including pure white for beads incorporating both the fluorophores. More than 80% quenching of pyrene emission was observed upon exposure of the polymer in the form of powder or as spin-coated films to the vapors of 4-NT while the emission of perylenebisimide was unaffected. The limit of detection was estimated at 10^-5 moles (2.7 ppm) of 4-NT vapors. The ease of synthesis of the material along with its invisible ink characteristics and nitro aromatic vapor detection opens up new opportunities for exploring the application of these PS-based materials as optical sensors and fluorescent ink for security purposes. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8SDS of cas: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reductive Electrophotocatalysis: Merging Electricity and Light To Achieve Extreme Reduction Potentials was written by Kim, Hyunwoo;Kim, Hyungjun;Lambert, Tristan H.;Lin, Song. And the article was included in Journal of the American Chemical Society in 2020.SDS of cas: 68716-49-4 This article mentions the following:

We describe a new electrophotocatalytic strategy that harnesses the power of light and electricity to generate an excited radical anion with a reducing potential of -3.2 V vs SCE, which can be used to activate substrates with very high reduction potentials (E_red ≈ -1.9 to -2.9 V). The resultant aryl radicals can be engaged in various synthetically useful transformations to furnish arylboronate, arylstannane, and biaryl products. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4SDS of cas: 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds was written by Adler, Pauline;Pons, Amandine;Li, Jing;Heider, Joerg;Brutiu, Bogdan R.;Maulide, Nuno. And the article was included in Angewandte Chemie, International Edition in 2018.Application In Synthesis of Sodium 2-methyl-2-propanethiolate This article mentions the following:

Phosphonates have garnered considerable attention for years owing to both their singular biol. properties and their synthetic potential. State-of-the-art methods for the preparation of mixed phosphonates, phosphonamidates, phosphonothioates, and phosphinates rely on harsh and poorly selective reaction conditions. We report herein a mild method for the modular preparation of phosphonylated derivatives, several of which exhibit interesting biol. activities, that is based on chemoselective activation with triflic anhydride. This procedure enables flexible and even iterative substitution with a broad range of O, S, N, and C nucleophiles. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Application In Synthesis of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Influence of processing conditions on the aroma profile of Litopenaeus vannamei by SPME-GC-MS was written by Duppeti, Haritha;Kempaiah, Bettadaiah Bheemanakere;Manjabhatta, Sachindra Nakkarike. And the article was included in Flavour and Fragrance Journal in 2022.Quality Control of Oct-1-en-3-ol This article mentions the following:

This study reports the aroma profile of Litopenaeus vannamei under different processing conditions such as raw, boiled, hot air dried, microwave dried and roasted using SPME-GC-MS. A total of 86 volatile compounds were identified, among which 38 compounds reported as aroma-active compounds (AAC) having the odor activity value (OAV) greater than one. The microwave-dried shrimp meat (MSM) exhibited the highest summation of odor activity value, and roasted shrimp meat (RSM) showed the highest concentration of aroma-active compounds (3448.78 μg/g). The partial least square regression (PLSR) anal. and cluster anal. (CA) showed that MSM and RSM are related to each other in their aroma characteristics while boiled shrimp meat (BSM) is different than these samples. The results of this study illustrate the typical volatile markers and the impact of processing methods on flavor generation in L. vannamei, which should be examined for the assessment of its freshness and product development based on shrimp flavor. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Quality Control of Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of nanoparticles on photopolymerization of acrylate monomers in forming nano-composites was written by Check, Casey;Chartoff, Richard;Chang, Sean. And the article was included in European Polymer Journal in 2015.Reference of 4074-88-8 This article mentions the following:

The UV photopolymerization of diethylene glycol-diacrylate and isobornyl-acrylate based nano-composites was studied with respect to reaction conversion with variations in UV light exposure. The composites contained various amounts of well dispersed ZrO₂ nanoparticles. The degree of conversion achieved vs light intensity was measured by DSC for various compositions ranging from 0 to 30% by weight of nanoparticles. It was found that including nanoparticles in the monomer increased the conversion achieved considerably. This is attributed to the acceleration of the reaction through interactions with the silane surface ligand on the nanoparticles. The upper limit for conversion was limited because of vitrification and was different for each monomer. Also noted was that the detailed effects of particle concentration on conversion are quite different for the two monomers. Conversion vs. UV exposure data such as those presented provide information necessary for determining the appropriate UV exposure required for creating nano-composites by inkjet printing with optimized phys., mech., and optical properties. The results indicate that it is important to determine this information for forming nano-composites from any specific monomer/nanoparticle combination. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon-Iodine Bonds was written by Cai, Aijie;Yan, Wenhao;Wang, Chao;Liu, Wei. And the article was included in Angewandte Chemie, International Edition in 2021.COA of Formula: C24H23ClO2 This article mentions the following:

A novel strategy that leveraged the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnished the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach was applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7COA of Formula: C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent was written by Liu, Yong;Laufer, Radoslaw;Patel, Narendra Kumar;Ng, Grace;Sampson, Peter B.;Li, Sze-Wan;Lang, Yunhui;Feher, Miklos;Brokx, Richard;Beletskaya, Irina;Hodgson, Richard;Plotnikova, Olga;Awrey, Donald E.;Qiu, Wei;Chirgadze, Nickolay Y.;Mason, Jacqueline M.;Wei, Xin;Lin, Dan Chi-Chia;Che, Yi;Kiarash, Reza;Fletcher, Graham C.;Mak, Tak W.;Bray, Mark R.;Pauls, Henry W.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Application of 5856-63-3 This article mentions the following:

This work describes a scaffold hopping exercise that begins with known imidazo[1,2-a]pyrazines, briefly explores pyrazolo[1,5-a][1,3,5]triazines, and ultimately yields pyrazolo[1,5-a]pyrimidines as a novel class of potent TTK inhibitors. An X-ray structure of a representative compound is consistent with 1¹/₂ type inhibition and provides structural insight to aid subsequent optimization of in vitro activity and physicochem. and pharmacokinetic properties. Incorporation of polar moieties in the hydrophobic and solvent accessible regions modulates physicochem. properties while maintaining potency. Compounds with enhanced oral exposure were identified for xenograft studies. The work culminates in the identification of a potent (TTK K_i = 0.1 nM), highly selective, orally bioavailable anticancer agent (CFI-402257) for IND enabling studies. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Ferrocene-Based NH-Free Phosphine-Oxazoline Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones was written by Wang, Yanzhao;Yang, Guoqiang;Xie, Fang;Zhang, Wanbin. And the article was included in Organic Letters in 2018.Synthetic Route of C8H9ClO This article mentions the following:

A new type of ferrocene-based phosphine-oxazoline ligand has been prepared over a few simple steps. An iridium complex of this ligand is air stable and exhibits excellent performance for the asym. hydrogenation of simple ketones (up to 98% yield, up to 99% ee, and 20000 S/C). Exo-α,β-unsaturated cyclic ketones could be regiospecifically hydrogenated to give chiral allylic alcs. with good results. This study indicates that P,N-ligands can also efficiently promote Ir-catalyzed asym. hydrogenation without NH-hydrogen-bonding assistance. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Synthetic Route of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts