35364-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35364-79-5, name is 2-(3,4-Dichlorophenyl)ethanol, molecular formula is C8H8Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
PREPARATION 14 Preparation of 3,4-dichlorophenethyl bromide STR37 Phosphorus tribromide (2.17 g) was added, dropwise, to a solution of 3,4-dichlorophenethyl alcohol (4.26 g) in carbon tetrachloride (30 ml). The mixture was stirred at room temperature for 10 minutes then heated under reflux for 2 hours. 5% Aqueous sodium carbonate (10 ml) was added dropwise and the mixture was extracted with dichloromethane (3*70 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give a yellow oil which was purified by column chromatography on silica eluding with dichloromethane containing hexane (30% down to 0%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a colourless oil, yield, 1.8 g. 1 H-N.M.R. (CDCl3) delta=7.50-7.30 (m, 2H); 7.15-7.05 (m, 1H); 3.65-3.50 (t, 2H); 3.20-3.10 (t, 2H) ppm.
The chemical industry reduces the impact on the environment during synthesis 35364-79-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Pfizer Inc.; US5340831; (1994); A;,
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