Martin-Acosta, Pedro; Meng, Qianli; Klimek, John; Reddy, Ashok P.; David, Larry; Petrie, Stefanie Kaech; Li, Bingbing X.; Xiao, Xiangshu published the artcile< A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target>, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol, the main research area is clickable photoaffinity probe betulinic acid tropomyosin; Betulinic acid; Cancer; Diazirine; Natural product; Photoaffinity probe; Tropomyosin.
Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge, unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for target identification. One major limitation of this approach is the efficient synthesis of appropriately substituted clickable photoaffinity probes. Herein, we describe an efficient and consistent method to prepare such probes. We further employed this method to prepare a highly stereo-congested probe based on naturally occurring triterpenoid betulinic acid. With this photoaffinity probe, we identified tropomyosin as a novel target for betulinic acid that can account for the unique biol. phenotype on cellular cytoskeleton induced by betulinic acid.
Acta Pharmaceutica Sinica B published new progress about Bioactive agents. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol.
Referemce:
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