Yuan, Chen; Jia, Wenyan; Yu, Ziyun; Li, Yanan; Zi, Min; Yuan, Li-Ming; Cui, Yong published the artcile< Are Highly Stable Covalent Organic Frameworks the Key to Universal Chiral Stationary Phases for Liquid and Gas Chromatographic Separations?>, SDS of cas: 6290-03-5, the main research area is covalent organic framework chiral stationary phase liquid gas chromatog.
High-performance liquid chromatog. (HPLC) and gas chromatog. (GC) over chiral stationary phases (CSPs) represent the most popular and highly applicable technol. in the field of chiral separation, but there are currently no CSPs that can be used for both liquid and gas chromatog. simultaneously. We demonstrate here that two olefin-linked covalent organic frameworks (COFs) featuring chiral crown ether groups can be general CSPs for extensive separation not only in GC but also in normal-phase and reversed-phase HPLC. Both COFs have the same 2D layered porous structure but channels of different sizes and display high stability under different chem. environments including water, organic solvents, acids, and bases. Chiral crown ethers are periodically aligned within the COF channels, allowing for enantioselective recognition of guest mols. through intermol. interactions. The COF-packed HPLC and GC columns show excellent complementarity and each affords high resolution, selectivity, and durability for the separation of a wide range of racemic compounds, including amino acids, esters, lactones, amides, alcs., aldehydes, ketones, and drugs. The resolution performances are comparable to and the versatility is superior to those of the most widely used com. chiral columns, showing promises for practical applications. This work thus advances COFs with high stability as potential universal CSPs for chromatog. that are otherwise hard or impossible to produce.
Journal of the American Chemical Society published new progress about Acids Role: ARU (Analytical Role, Unclassified), ANST (Analytical Study). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, SDS of cas: 6290-03-5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts