Ghinato, Simone; Dilauro, Giuseppe; Perna, Filippo Maria; Capriati, Vito; Blangetti, Marco; Prandi, Cristina published the artcile< Directed ortho-metalation-nucleophilic acyl substitution strategies in deep eutectic solvents: the organolithium base dictates the chemoselectivity>, Recommanded Product: Triphenylmethanol, the main research area is benzamide preparation chemoselective green chem; diisopropyl arylamide boron compound Suzuki Miyaura cross coupling; electrophile diisopropyl arylamide ortho metalation nucleophilic acyl substitution; alkyl aryl ketone preparation chemoselective; organolithium diisopropyl arylamide nucleophilic acyl substitution.
Directed ortho metalation (DoM) or nucleophilic acyl substitution (SNAc) can be efficiently programmed on the same aromatic carboxylic acid amide RC(O)N(i-Pr)2 (R = Ph, 4-H3COC6H4, 4-ClC6H4, 3-H3CC6H4, 1-methyl-1H-indol-2-yl), in a choline chloride-based eutectic mixture, by simply switching the nature of the organolithium reagent R1Li (R1 = Bu, Me, Ph, hexyl). Telescoped, one-pot ortho-lithiation/Suzuki-Miyaura cross-couplings have also been demonstrated for the first time in deep eutectic solvents.
Chemical Communications (Cambridge, United Kingdom) published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Recommanded Product: Triphenylmethanol.
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