Related Products of 702-82-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, molecular weight is 167.2481, as common compound, the synthetic route is as follows.
In a clean round bottom flask, (100gm) of 1-amino-3-adamantol in l000ml of acetonitrile were charged. 239.8gm of potassium carbonate was charged to the above flask. The reaction mass was heated to 82-85C. The compound of formula III (4x25gm), was charged after 60-90 mm intervals. After completion of reaction, the reaction mass was cooled to 65-70C. The reaction mass was filtered and the solid was washed with 500m1 acetonitrile and suck dried. Theacetonitrile was distilled out from filtrate under vacuum at 50-55C. Ethyl acetate was charged to the residue and the slurry stirred at 50-55C for 30-45 minutes. The slurry was cooled to 20-30C and stirred for 60-90 minutes. The solid was filtered and washed with ethyl acetate and suck dried, The wet cake was suspended in IPA and heated to 80-85C to get a clear solution. The clear solution was charcoalised and filtered through hyflo. The filtrate was distilled oUt undervacuum to get final volume to 5Volume. The reaction mass was cooled to -5 to 5C and stirred for 60-90 minutes. The solid was filtered and washed with IPA and suck dried. The solid was dried under vacuum at 50-55C. 105 to 120gm of solid was obtained (yield 59-68%, HPLC purity >98%)
The chemical industry reduces the impact on the environment during synthesis 702-82-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED; BHIRUD, Shekhar Bhaskar; BHUSHAN, Kumar Hari; THANEDAR, Amit Anant; RAUT, Changdev Namdev; CHAND, Prem; WO2014/102815; (2014); A1;,
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