Barre, Annick; Bourne, Yves; Van Damme, Els J. M.; Rouge, Pierre published the artcile< Overview of the structure-function relationships of mannose-specific lectins from plants, algae and fungi>, Formula: C6H12O6, the main research area is review Araucaria Phlebodium mannose lectin; function; fungi; lectin; mannose-binding specificity; plant; structure; use as tools.
To date, a number of mannose-binding lectins have been isolated and characterized from plants and fungi. These proteins are composed of different structural scaffold structures which harbor a single or multiple carbohydrate-binding sites involved in the specific recognition of mannose-containing glycans. Generally, the mannose-binding site consists of a small, central, carbohydrate-binding pocket responsible for the “”broadsugar-binding specificity”” toward a single mannose mol., surrounded by a more extended binding area responsible for the specific recognition of larger mannose-containing N-glycan chains. Accordingly, the mannose-binding specificity of the so-called mannose-binding lectins towards complex mannose-containing N-glycans depends largely on the topog. of their mannose-binding site(s). This structure-function relationship introduces a high degree of specificity in the apparently homogeneous group of mannose-binding lectins, with respect to the specific recognition of high-mannose and complex N-glycans. Because of the high specificity towards mannose these lectins are valuable tools for deciphering and characterizing the complex mannose-containing glycans that decorate both normal and transformed cells, e.g., the altered high-mannose N-glycans that often occur at the surface of various cancer cells.
International Journal of Molecular Sciences published new progress about Araucaria brasiliana Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.
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