Kumar, Ravi; Rajarajeshwari, N.; Swamy V. B., Narayana published the artcile< Borassus flabellifer fruit mucilage: potential biodegradable carrier for colon specific drug delivery>, Formula: C14H8N2Na2O6, the main research area is olsalazine sodium Borassus mucilage colon matrix tablet drug delivery.
The present study was undertaken to assess the potential of Borassus flabellifer mucilage (BFM) to act as a biodegradable carrier for colon specific drug delivery. Hence an attempt was made to develop matrix tablet of olsalazine sodium based formulation using BFM which protects the drug in upper GIT and release the major amount of drug in colon due to degradation by bacterial enzymes. Colon targeted matrix tablets of olsalazine sodium were prepared by direct compression method using different concentrations viz; 5, 10, 15, 20 and 25 % weight/weight of BFM. Tablets were evaluated for hardness, friability, weight variation, drug content, in vitro dissolution test in simulated gastric, intestinal and colonic fluid with and without 4% (w/v) rat cecal matter and stability study. FT-IR and DSC studies confirmed the absence of any drug polymer interaction. In vitro studies revealed that the tablets containing 25% weight/weight of BFM (F5) have limited the drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment. Optimized formulation (F5) showed no change either in phys. appearance, drug content or in dissolution pattern after storage at 40°C/RH 75% for 3 mo. Math. modeling showed that release pattern follows the Peppas model. X-ray images were taken to investigate the movement, location and the integrity of the tablets in different parts of gastro intestinal tract in rabbits and it clearly supported the in vitro study. The study showed that BFM can be used successfully for colon specific drug delivery system.
International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Biodegradability. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Formula: C14H8N2Na2O6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts