Iles, Bruno; Ribeiro de Sa Guimaraes Noleto, Isabela; Dourado, Flaviane Franca; de Oliveira Silva Ribeiro, Fabio; de Araujo, Alyne Rodrigues; de Oliveira, Taiane Maria; Souza, Jessica Maria Teles; Barros, Ayslan Batista; Sousa, Gabrielle Costa; de Jesus Oliveira, Antonia Carla; da Silva Martins, Conceicao; de Oliveira Viana Veras, Mariana; de Carvalho Leitao, Renata Ferreira; de Souza de Almeida Leite, Jose Roberto; da Silva, Durcilene Alves; Medeiros, Jand Venes Rolim published the artcile< Alendronate sodium-polymeric nanoparticles display low toxicity in gastric mucosal of rats and Ofcol II cells>, Synthetic Route of 492-62-6, the main research area is alendronate sodium polymeric nanoparticle gastric toxicity osteotoxicity; Alendronate; Cashew gum; Gastric lesion; Polymeric nanoparticle; Red Angico gum.
The use of bisphosphonates constitutes the gold-standard therapy for the control and treatment of bone diseases. However, its long-term use may lead to gastric problems, which limits the treatment. Thus, this study aimed to formulate a nanostructured system with biodegradable polymers for the controlled release of alendronate sodium. The nanoparticles were characterized, and its gastric toxicity was investigated in rats. The synthesis process proved to be effective for encapsulating alendronate sodium, exhibiting nanoparticles with an average size of 51.02 nm and 98.5% of alendronate sodium incorporation. The release tests demonstrated a controlled release of the drug in 420 min, while the morphol. analyzes showed spherical shapes and no apparent roughness. The biol. tests demonstrated that the alendronate sodium nanoformulation reversed the gastric lesions, maintaining the normal levels of malondialdehyde and myeloperoxidase. Also, the encapsulated alendronate sodium showed no toxicity in murine osteoblastic cells, even at high concentrations
NanoImpact published new progress about Anacardium occidentale. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts