Kitowski, Annabel; Bernardes, Goncalo J. L. published the artcile< A Sweet Galactose Transfer: Metabolic Oligosaccharide Engineering as a Tool To Study Glycans in Plasmodium Infection>, SDS of cas: 4064-06-6, the main research area is GLUT1 galactose O glycosylation plasmodium infection malaria; GLUT1 transporters; bioorthogonal chemistry; carbohydrates; inverse electron-demand Diels-Alder; malaria.
The introduction of chem. reporter groups into glycan structures through metabolic oligosaccharide engineering followed by bio-orthogonal ligation is an important tool to study glycosylation. We show the incorporation of synthetic galactose derivatives that bear terminal alkene groups in hepatic cells, with and without infection by Plasmodium berghei parasites, the causative agent of malaria. Addnl., we demonstrated the contribution of GLUT1 to the transport of these galactose derivatives, and observed a consistent increase in the uptake of these compounds going from naive to P. berghei-infected cells. Finally, we used MOE to study the interplay between Plasmodium parasites and their mosquito hosts, to reveal a possible transfer of galactose building blocks from the latter to the former. This strategy has the potential to provide new insights into Plasmodium glycobiol. as well as for the identification and characterization of key glycan structures for further vaccine development.
ChemBioChem published new progress about Cell culture. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts