Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 5299-60-5
This was synthesized essentially following the procedurereported previously.30 Briefly, a mixture of tert-butyldimethylsilylchloride(1.84 g, 12.21 mmol), imidazole (816 mg, 11.99 mmol)and ethyl 6-hydroxyhexanoate (640 mg, 3.99 mmol) in DMF (10mL) was stirred under nitrogen at 20 C. After 24 h, the reactionmixture was diluted with ether (50 mL) and the ethereal solutionwashed with brine (150 mL 3). The ether solution was separated,dried over Na2SO4, and the ether removed by rotary evaporation toobtain a yellow oil. A methanolic solution of Triton B (40% w/w, 10mL) was added to this and the mixture stirred at 20 C for an hour.Methanol was removed under vacuum, water (20 mL) was addedto the residue and the pH adjusted to 4 using 1 M HCl. The aqueousphase was then extracted with ether (100 mL 3) and the combinedether solution was dried over Na2SO4. Ether was evaporatedto yield 609 mg (2.47 mmol, 61.9%) of compound 3 as a yellow oil:1H NMR (CDCl3) d 0.04 (s, 6H), 0.89 (s, 9H), 1.40 (dd, 2H), 1.53 (m,2H), 1.65 (m, 2H), 3.61 (t, 2H)
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Reference:
Article; Zhou, Zhengyuan; Chitneni, Satish K; Devoogdt, Nick; Zalutsky, Michael R.; Vaidyanathan, Ganesan; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1939 – 1949;,
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