Henke, Bettina; Westerlund, Douglas published the artcile< Hydrophobic chromatography and bioanalysis of some polar pyridine derivatives used as antilipolytic agents>, Category: alcohols-buliding-blocks, the main research area is pyridine derivative determination plasma chromatog; hypolipidemic determination plasma chromatog.
The antilipolytic compounds 5-fluoro-3-pyridinecarboxylic acid [402-66-4] and 5-fluoro-3-hydroxymethylpyridine [22620-32-2] were determined quant. in plasma (precisions = 5-7% in the concentration range 1-20 μg/mL) by liquid chromatog. on LiChrosorb RP-8 (5 μm) with phosphate buffer pH 3-4 as mobile phase, after precipitation of proteins and direct injection of the supernatant. Detection limits were 0.1-0.2 μg/mL plasma. The chromatog. retention was explained by adsorption of the uncharged compounds on to the support complemented by ion-pair adsorption with buffer components at extreme pH values.
Journal of Chromatography published new progress about Blood analysis. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Category: alcohols-buliding-blocks.
Referemce:
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