Genc, Sertac’s team published research in Journal of Organic Chemistry in 2019-05-17 | 5344-90-1

Journal of Organic Chemistry published new progress about Alkylation (β-, of secondary alcs. with primary alcs.). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Genc, Sertac; Arslan, Burcu; Gulcemal, Suleyman; Gunnaz, Salih; Cetinkaya, Bekir; Gulcemal, Derya published the artcile< Iridium(I)-Catalyzed C-C and C-N Bond Formation Reactions via the Borrowing Hydrogen Strategy>, Computed Properties of 5344-90-1, the main research area is secondary aminobenzyl alc alkylation cyclization iridium catalyst.

Iridium(I) complexes having an imidazol-2-ylidene ligand with benzylic wingtips efficiently catalyzed the β-alkylation of secondary alcs. with primary alcs. and acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones through a borrowing hydrogen pathway. The β-alkylated alcs., including cholesterol derivatives, and substituted quinolines were obtained in good yields by using a minute amount of the catalyst with a catalytic amount of NaOH or KOH under the air atm., liberating water (and H2 in the case of quinoline synthesis) as the sole byproduct. Notably, this system demonstrated turnover numbers of 940,000 (for β-alkylation of secondary alcs. with primary alcs. by using down to 0.0001 mol % = 1 ppm of the catalyst) and 9200 (acceptorless dehydrogenative cyclization of 2-aminobenzyl alc. with ketones).

Journal of Organic Chemistry published new progress about Alkylation (β-, of secondary alcs. with primary alcs.). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts