Marinho, Juliane Aparecida; Martins Guimaraes, Daniel Silqueira; Glanzmann, Nicolas; de Almeida Pimentel, Giovana; Karine da Costa Nunes, Izabelle; Gualberto Pereira, Henrique Marcelo; Navarro, Maribel; de Pilla Varotti, Fernando; David da Silva, Adilson; Abramo, Clarice published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization》.HPLC of Formula: 26153-38-8 The article contains the following contents:
Chloroquine (CQ) has been the main treatment for malaria in regions where there are no resistant strains. Mol. hybridization techniques have been used as a tool in the search for new drugs and was implemented in the present study in an attempt to produce compound candidates to treat malarial infections by CQ-resistant strains. Two groups of mols. were produced from the 4-aminoquinoline ring in conjugation to hydrazones (HQ) and imines (IQ). Physicochem. and pharmacokinetic properties were found to be favorable when analyzed in silico and cytotoxicity and antiplasmodial activity were assayed in vitro and in vivo showing low cytotoxicity and selectiveness to the parasites. Candidates IQ5 and IQ6 showed important values of parasite growth inhibition in vivo on the 5th day after infection (IQ5 15 mg/kg = 72.64% and IQ6 15 mg/kg = 71.15% and 25 mg/kg = 93.7%). IQ6 also showed interaction with ferriprotoporphyrin IX similarly to CQ. The process of applying condensation reactions to yield imines is promising and capable of producing mols. with antiplasmodial activity. In the experiment, the researchers used many compounds, for example, 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8
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