The author of 《Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children》 were Mack, David R.; Saul, Bradley; Boyle, Brendan; Griffiths, Anne; Sauer, Cary; Markowitz, James; LeLeiko, Neal; Keljo, David; Rosh, Joel R.; Baker, Susan S.; Steiner, Steve; Heyman, Melvin B.; Patel, Ashish S.; Baldassano, Robert; Noe, Joshua; Rufo, Paul; Kugathasan, Subra; Walters, Thomas; Marquis, Alison; Thomas, Sonia M.; Denson, Lee; Hyams, Jeffrey. And the article was published in Journal of Pediatric Gastroenterology and Nutrition in 2020. Related Products of 23828-92-4 The author mentioned the following in the article:
The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis. A cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize predictive ability of disease attributes based on clin. disease severity using Pediatric Ulcerative Colitis Activity Index (PUCAI), severe (65+) vs. not severe (<65) and total Mayo score, severe (10-12) vs. not severe (<10); mucosal disease by Mayo endoscopic subscore, severe (3) vs. not severe (<3); and extensive disease vs. not extensive (left-sided and proctosigmoiditis). Mean age was 12.7 years; 49.6% (n = 212) were girls, and 83% (n = 351) were Caucasian. Severe total Mayo score was present in 28% (n = 120), mean PUCAI score was 49.820.1, and 33% (n = 142) had severe mucosal disease with extensive involvement in 82% (n = 353). Classification and regression trees identified white blood cell count, erythrocyte sedimentation rate, and platelet count (PLT) as the set of 3 best blood laboratory tests to predict disease extent and severity. For mucosal severity, albumin (Alb) replaced PLT. Classification models for PUCAI and total Mayo provided sensitivity of at least 0.65 using standard clin. cut-points with misclassification rates of approx. 30%. A combination of the white blood cell count, erythrocyte sedimentation rate, and either PLT or albumin is the best predictive subset of standard laboratory tests to identify severe from nonsevere clin. or mucosal disease at diagnosis in relation to objective clin. scores. After reading the article, we found that the author used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Related Products of 23828-92-4)
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a mucolytic expectorant and a metabolite of bromhexine.Related Products of 23828-92-4 It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.
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