Sawano, Takahiro; Matsui, Takeshi; Koga, Marina; Ishikawa, Eri; Takeuchi, Ryo published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Iridium-catalyzed C3-selective asymmetric allylation of 7-azaindoles with secondary allylic alcohols》.Name: Oxetan-3-ol The article contains the following contents:
Iridium-catalyzed C3-selective asym. allylation of 7-azaindoles with racemic secondary allylic alcs. to give only branched allylation products in good to high yields with high enantioselectivity (up to >99.5% ee) was reported. Allylic alcs. and 7-azaindoles with a variety of functional groups including halogen and heteroaromatic groups were compatible with the reaction conditions. Furthermore, transformations of the obtained allylation products were demonstrated without a significant loss of enantiomeric excess. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol
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