《Drug-Encapsulated Cyclodextrin (CD) Nanosponges (NSs)》 was published in Methods in Molecular Biology (New York, NY, United States) in 2021. These research results belong to Tannous, Maria; Caldera, Fabrizio; Hoti, Gjylije; Dianzani, Umberto; Cavalli, Roberta; Trotta, Francesco. Formula: C6H12O6 The article mentions the following:
A review. To date, a number of nanocarriers, either inorganic or organic, have been developed to improve the delivery and therapeutic efficacy of various drugs. Drug delivery systems have attempted to overcome the undesirable pharmacokinetic problems encountered. Among the various nanomaterials that have been designed as potential nanocarriers, cyclodextrin-based polymers are of particular interest in this review. Cyclodextrins (CD) are a class of cyclic glucopyranose oligomers, obtained from starch by enzymic action, with a characteristic toroidal shape that forms a truncated cone-shaped lipophilic cavity. The main common native cyclodextrins are named α, β, and γ which comprise six, seven, and eight glucopyranose units, resp. Cyclodextrins have the capability to include compounds whose size and polarity are compatible with those of their cavity. Cyclodextrin-based crosslinked polymers, often referred to as ”cyclodextrin nanosponges” (CDNSs), attract great attention from researchers for solving major bioavailability problems such as inadequate solubility, poor dissolution rate, and limited stability of some agents, as well as increasing their effectiveness and decreasing unwanted side effects. Registered patents about this novel system in various fields, different pharmaceutical applications, and classes of drugs encapsulated by CDNSs are detailed. The features outlined make CDNSs a promising platform for the development of innovative and advanced delivery systems. In the experimental materials used by the author, we found rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Formula: C6H12O6)
rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Formula: C6H12O6
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