In 2021,Journal of Materials Chemistry B: Materials for Biology and Medicine included an article by Jiang, Bowen; Hao, Dengyuan; Li, Chaonan; Lu, Shaojin; Pei, Qing; Xie, Zhigang. Quality Control of 3,3,3-Trifluoropropan-1-ol. The article was titled 《Fluorinated paclitaxel prodrugs for potentiated stability and chemotherapy》. The information in the text is summarized as follows:
Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy. The experimental part of the paper was very detailed, including the reaction process of 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Quality Control of 3,3,3-Trifluoropropan-1-ol)
3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Quality Control of 3,3,3-Trifluoropropan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts