In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, the common compound, a new synthetic route is introduced below. Application In Synthesis of 1,1-Bis(Hydroxymethyl)cyclopropane
(0236) To a stirred solution of (1-hydroxymethyl-cyclopropyl)-methanol (Combi-blocks, 10.0 g, 97.9 mmol) and triethylamine (22.0 g, 220 mmol) in DCM (120 mL) at -5 C. was added thionyl chloride (13.0 g, 110 mmol) dropwise over 30 min. The resulting suspension was stirred at -5 C. for an additional 2 h and then diluted with water (100 mL). The organic phase was separated, washed with brine, dried over sodium sulfate and filtered. The filtrate was dried under reduced pressure to give 5,7-dioxa-6-thia-spiro[2.5]octane 6-oxide as a white solid (13.5 g, 93%). 1HNMR (CDCl3, 300 MHz): delta 5.26-5.30 (d, 2H, J=11.4 Hz), 3.06-3.10 (d, 2H, J=11.7 Hz), 0.84-0.89 (m, 2H), 0.49-0.54 (m, 2H).
The synthetic route of 39590-81-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HUDSON BIOPHARMA INC.; Chen, Yi; Ding, Qingjie (Jack); Sun, Yang-sheng; US2015/322076; (2015); A1;,
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