Synthetic Route of 1805-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(3,4-Dichlorophenyl)methanol 7a (500 mg, 2.84 mmol) and triethylamine (860 mg, 8.52 mmol) were dissolved in 10 mL of dichloromethane, and methanesulfonyl chloride (481 mg, 4.26 mmol) was added dropwise at 0 C. ), react at room temperature for 6 hours. Add 50mL of 10% citric acid solution, extract with dichloromethane (50mL ¡Á 3), and combine the organic phase, wash with saturated sodium bicarbonate solution (50mL) and saturated sodium chloride solution (50mL ¡Á 1), the organic phase is anhydrous Drying over sodium sulfate and concentrating under reduced pressure afforded 3,4-dichlorobenzyl methanesulfonate 7b (724 mg, white solid).
According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Guan Dongliang; Wang Zhongli; Bai Hua; Liu Zhubo; Meng Lichen; Zhao Weifeng; Ling Long; Wang Yan; (78 pag.)CN109574927; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts