Related Products of 33420-52-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33420-52-9, name is 2,2-Difluoropropan-1-ol. A new synthetic method of this compound is introduced below.
2-Chloro-6-methylpyridine-3-carbonitrile (600 mg; 3.93 mmol) in 10 mL of N,N- dimethylformamide is cooled to 0C and sodium hydride (55% in mineral oil) (429 mg; 9.83 mmol) is added to the reaction mixture. After stirring for a few minutes, 2,2-difluoropropan-1- ol (453 mg; 4.72 mmol) is added and the reaction mixture is stirred for 2 hours at 50C. The reaction mixture is quenched with methanol, filtered and purified by reverse phase chromatography-HPLC (modifier: trifluoroacetic acid) Yield: 355 mg (43 % of theory) (0309) Mass spectrometry (ESI+): m/z = 213 [M+H]+ (0310) HPLC (Method 3): Retention time = 1.020 min
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33420-52-9, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TRIESELMANN, Thomas; GODBOUT, Cedrickx; HOENKE, Christoph; VINTONYAK, Viktor; (130 pag.)WO2019/149660; (2019); A1;,
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