Kirhan, Idris; Kas, Fehmi; Taskiran, Huseyin; Buyukhatipoglu, Hakan; Gonel, Ataman; Koyuncu, Ismail published the artcile< Evaluation of Micro-RNA Levels, Apoptosis and Oxidative Stress Markers in Patients Recieving Chemotherapy>, SDS of cas: 1492-18-8, the main research area is cancer microRNA apoptosis oxidative stress marker chemotherapy; DNA damage; Micro-RNA; apoptosis; cancer; chemotherapy; damage; injury; metastasis; miR-29a; miRNA; prognosis..
Objective: The primary objective of this study was to compare oxidative DNA damage markers, apoptosis markers and changes in miRNA levels in patients diagnosed with cancer and treated through chemotherapy. Our secondary objective was also to evaluate tumor responses that can be determined after post-chemotherapy clin. evaluations by phys. examinations, laboratory results and radiol. imagings, and to compare the clin. results to oxidative stress and apoptosis markers and micro RNA levels. Materials and Methods: To do that we designed a prospective observational cross-sectional study. A total of 34 cancer patients and 27 healthy controls were included in the study from the Harran University School of Medicine Department of Oncol. Newly diagnosed chemotherapy or radiotherapy naive patients without any chronic diseases were included into the study. Patients with a poor performance status (ECOG 2 and 3) and patients who did not meet the inclusion criteria were excluded. The cancer patients received chemotherapy according to their scheduled periods. Blood samples were taken from the patients before the first chemotherapy course and before the second chemotherapy round. Patients were called for toxicity control on the 10th day after the chemotherapy. However, there were subtle differences between pre-chemotherapy and post-chemotherapy levels. Mir-29a expressions were lower in cancer patients as compared to controls.
Combinatorial Chemistry & High Throughput Screening published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, SDS of cas: 1492-18-8.
Referemce:
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