Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 616-29-5
Synthesis of 2,2,12,12-t-methyl-3,11-dioxo-4,10-dioxa-5,9-diazatridecan-7-ol (N,N’-di-t-boc-2-hydroxy-1,3-diaminopropane) Sodium hydrogencarbonate (8.3 g, 99 mmol) was dissolved in 1:1 acetonitrile:water mixture (190 mL) and the solution cooled to 4 C. in an ice bath. 1,3-diamino-2-hydroxypropane (2.5 g, 27 mmol) and di-tert-butyldicarbonate (12.8 g, 59 mmol) were dissolved in the same solvent system (65 mL). This mixture was then added to the chilled sodium hydrogencarbonate solution and stirred on ice for two hours. The reaction was then heated to room temperature and stirred overnight. The acetonitrile was removed by rotary evaporation and the protected amine extracted into dichloromethane (3*75 mL portions). The organic portions were combined, dried over sodium carbonate, and evaporated to dryness by rotary evaporation. The resulting oil was re-crystallised from diethylether/hexane,38 giving colourless crystals (7.2 g, 91% yield). The compound was characterised by 1H and 13C NMR and FT-IR spectroscopy. IR (cm-1): 3316 m br v(OH and NH), 2971 m and 2930 m v(CH3 and CH), 1681 s v(C=O). 1H NMR (400 MHz, CDCl3, 298 K) [delta, ppm]: 1.45 (s, 18H, H-1), 3.20 (m, 4H, H-5), 3.75 (m, 2H, H-6 and H-7), 5.20 (s br, 2H, H-4). 13C NMR (100 MHz, CDCl3, 298K) [delta, ppm]: 28.55 (C-1), 43.72 (C-2), 71.07 (C-5), 79.87 (C-6), 157.24 (C-3).
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Reference:
Patent; UNIVERSITY OF KWAZULU-NATAL; Munro, Orde Quentin; Akerman, Kate Julie; Akerman, Piers; US2013/90472; (2013); A1;,
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