Malekzadeh, Parisa; Cowan, Kenneth; Steinberg, Seth M.; Camphausen, Kevin A.; Shriver, Craig; Merino, Maria J.; Good, Meghan L.; Berman, Arlene; Danforth, David N. Jr published the artcile< Twenty-five-Year Follow-up of a Prospective Randomized Trial Comparing Preoperative Versus Postoperative FLAC/Granulocyte Colony-Stimulating Factor Chemotherapy for Stage II Breast Cancer>, Related Products of 1492-18-8, the main research area is breast cancer stimulating factor chemotherapy.
Patients and methods: We conducted a single-institution prospective randomized control trial comparing preoperative or postoperative fluorouracil, leucovorin calcium, doxorubicin, and cyclophosphamides/granulocyte colony-stimulating factor chemotherapy for women with untreated clin. stage II breast cancer. Long-term follow-up was conducted to define toxicities, recurrence patterns and RFS and OS. Results: Fifty-three women with clin. stage II breast cancer were randomized, 26 patients to receive preoperative chemotherapy and 27 to receive postoperative chemotherapy. Long-term follow-up, with a median of 25.3 years, was obtained. Local or systemic recurrence occurred in 8 women in the preoperative group and in 10 women in the postoperative group, and recurrences were predominantly within 10 years of treatment. Late toxicities included local upper extremity paresthesia’s, upper extremity edema and congestive heart failure in 1 patient each. Anal. revealed no difference in RFS (20-yr RFS probabilities; preoperative: 61.3%, postoperative: 54.7%, P=0.42), or in OS between the 2 treatment groups (20-yr probabilities, preoperative: 64.6%, postoperative: 62.2%, P=0.44). Twenty-five of 53 patients (47%) were alive and without disease at this follow-up.
American Journal of Clinical Oncology published new progress about Chemotherapy. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Related Products of 1492-18-8.
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