Adding a certain compound to certain chemical reactions, such as: 39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39590-81-3, blongs to alcohols-buliding-blocks compound. 39590-81-3
Step 1 : EDCI (104 mg, 0.54 mmol) was added to a mixture of N-Cbz-O-TBDMS-D-serine (200 mg, 0.45 mmol), l,l-di(hydroxymethyl)cyclopropane (116 mg, 1.13 mmol) and DMAP (55 mg, 0.45 mmol) in dry DCM (10 mL) and stirred at rt for 6 hours. Evaporated and chromatographed on silica using EtOAc: heptane as eluent. The Cbz-ester was isolated (140 mg, 70%) as a clear oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39590-81-3, its application will become more common.
Reference:
Patent; LEO PHARMA A/S; LARSEN, Mogens; RITZEN, Andreas; N?RREMARK, Bjarne; GREVE, Daniel Rodriguez; (145 pag.)WO2018/141842; (2018); A1;,
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