Elorriaga, David; de la Cruz-Martinez, Felipe; Rodriguez-Alvarez, Maria Jesus; Lara-Sanchez, Agustin; Castro-Osma, Jose Antonio; Garcia-Alvarez, Joaquin published the artcile< Fast Addition of s-Block Organometallic Reagents to CO2-Derived Cyclic Carbonates at Room Temperature, Under Air, and in 2-Methyltetrahydrofuran>, Computed Properties of 76-84-6, the main research area is tertiary alc hydroxy ester ketone preparation green solvent methyltetrahydrofuran; organomagnesium lithium reagents cyclic carbonate addition ring opening; CO2; Grignard reagents; cyclic carbonates; green chemistry; organolithium compounds.
Fast addition of highly polar organometallic reagents (RMgX/RLi) to cyclic carbonates (derived from CO2 as a sustainable C1 synthon) has been studied in 2-methyltetrahydrofuran as a green reaction medium or in the absence of external volatile organic solvents, at room temperature, and in the presence of air/moisture. These reaction conditions are generally forbidden with these highly reactive main-group organometallic compounds The correct stoichiometry and nature of the polar organometallic alkylating or arylating reagent allows straightforward synthesis of highly substituted tertiary alcs., β-hydroxy esters, or sym. ketones, working always under air and at room temperature Finally, an unprecedented one-pot/two-step hybrid protocol is developed through combination of an Al-catalyzed cycloaddition of CO2 and propylene oxide with the concomitant fast addition of RLi reagents to the in situ and transiently formed cyclic carbonate, thus allowing indirect conversion of CO2 into the desired highly substituted tertiary alcs. without need for isolation or purification of any reaction intermediates.
ChemSusChem published new progress about Addition reaction. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Computed Properties of 76-84-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts