Reference of 929-06-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
a) [2-(2-Hydroxy-ethoxy)-ethyl]-carbamic acid terf-butyl esterTo a solution of 2-(2-amino-ethoxy)-ethanol (5.00 g) in water (35 mL) at 00C potassium hydroxide (2.93 g) was added. To this mixture maintained at O0C, a solution of d-tert- butyldicarbonate (11.40 g) in dioxane (17 mL) was added dropwise. The resulting mixture was stirred at 00C for 1 h and then 4 h at room temperature. Dioxane was evaporated under reduced pressure and the aqueous solution was extracted with DCM (2 x 25 mL). The organic phase was dried and evaporated under reduced pressure. The residue was purified by flash chromatography (silica gel, EtOAc / petroleum ether 40 /60 to 60 / 40) to give the title compound (8.50 g); ESMS m/z 205.3 [M+H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 929-06-6, 2-(2-Aminoethoxy)ethanol.
Reference:
Patent; GLAXO GROUP LIMITED; PLIVA-ISTRAZIVACKI INSTITUT D.O.O.; WO2006/50942; (2006); A1;,
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