Teruel, Adrian H.; Perez-Esteve, Edgar; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Costero, Ana M.; Ferri, Daniel; Gavina, Pablo; Merino, Virginia; Martinez-Manez, Ramon; Sancenon, Felix published the artcile< Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is silica microparticle hydrocortisone inflammatory bowel disease antiinflammatory; colon targeted release; gated materials; inflammatory bowel disease; mesoporous silica microparticles; smart drug delivery materials.
Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of S1 and S2 in water at an acidic and a neutral pH show negligible dye/drug release, yet a notable delivery took place when the reducing agent sodium dithionite is added because of hydrolysis of an azo bond in the capping ensemble. Addnl., olsalazine fragmentation induced 5-aminosalicylic acid (5-ASA) release. In vitro digestion models show that S1 and S2 solids are suitable systems to specifically release a pharmaceutical agent in the colon. In vivo pharmacokinetic studies in rats show a preferential rhodamine B release from S1 in the colon. Moreover, a model of ulcerative colitis is induced in rats by oral administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) solutions, which was also used to prove the efficacy of S2 for colitis treatment. The specific delivery of hydrocortisone and 5-ASA from S2 material to the colon tissue in injured rats markedly lowers the colon/body weight ratio and the clin. activity score. Histol. studies showed a remarkable reduction in inflammation, as well as an intensive regeneration of the affected tissues.
Molecular Pharmaceutics published new progress about Anti-inflammatory agents. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts